To Evaluate the Efficacy and Safety of Pegozafermin in Subjects With Severe Hypertriglyceridemia
Public ClinicalTrials.gov record NCT05852431. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Pegozafermin in Subjects With Severe Hypertriglyceridemia (SHTG): The ENTRUST Study
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
To determine the effect of Pegozafermin on fasting serum triglyceride levels in subjects with Severe Hypertriglyceridemia (TG ≥500 to ≤2000 mg/dL) after 26 weeks of treatment.
Study identification
- NCT ID
- NCT05852431
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 369 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 22 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 15, 2023 (Actual)
- Primary completion
- Jul 7, 2025 (Actual)
- Completion
- Apr 9, 2026 (Actual)
- Last update posted
- Jul 7, 2026
2023 – 2026
United States locations
- U.S. sites
- 73
- U.S. states
- 26
- U.S. cities
- 68
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| 89bio Clinical Study Site | Chandler | Arizona | 85712 | — |
| 89bio Clinical Study Site | Peoria | Arizona | 85381 | — |
| 89Bio Clinical Study Site | Tucson | Arizona | 85712 | — |
| 89bio Clinical Study Site | Conway | Arkansas | 72032 | — |
| 89bio Clinical Study Site | Jonesboro | Arkansas | 72401 | — |
| 89bio Clinical Study Site | Little Rock | Arkansas | 72205 | — |
| 89bio Clinical Trial Site | Huntington Park | California | 90255 | — |
| 89Bio Clinical Study Site | Long Beach | California | 90815 | — |
| 89bio Clinical Study Site | Los Angeles | California | 90057 | — |
| 89bio Clinical Trial Site | Northridge | California | 91325 | — |
| 89bio Clinical Trial Site | Panorama City | California | 91402 | — |
| 89bio Clinical Study Site | Santa Ana | California | 92705 | — |
| 89bio Clinical Trial Site | Santa Ana | California | 92705 | — |
| 89bio Clinical Study Site | Thousand Oaks | California | 91360 | — |
| 89Bio Clinical Study Site | Tustin | California | 92780 | — |
| 89bio Clinical Study Site | Wheat Ridge | Colorado | 80033 | — |
| 89bio Clinical Trial Site | Wheat Ridge | Colorado | 80033 | — |
| 89bio Clinical Study Site | Bridgeport | Connecticut | 06610 | — |
| 89Bio Clinical Study Site | Clearwater | Florida | 33756 | — |
| 89bio Clinical Study Site | Clearwater | Florida | 33761 | — |
| 89bio Clinical Study Site | Hialeah Gardens | Florida | 33016 | — |
| 89Bio Clinical Study Site | Homestead | Florida | 33030 | — |
| 89Bio Clinical Study Site | Miami Lakes | Florida | 33014 | — |
| 89bio Clinical Study Site | Miramar | Florida | 33027 | — |
| 89Bio Clinical Study Site | Orlando | Florida | 32825 | — |
| 89bio Clinical Study Site | Panama City | Florida | 32401 | — |
| 89bio Clinical Trial Site | Port Orange | Florida | 32127 | — |
| 89Bio Clinical Study Site | Tampa | Florida | 33606 | — |
| 89bio Clinical Study Site | Atlanta | Georgia | 30309 | — |
| 89Bio Clinical Study Site | Columbus | Georgia | 31904 | — |
| 89Bio Clinical Study Site | Lawrenceville | Georgia | 30044 | — |
| 89Bio Clinical Study Site | Chicago | Illinois | 60607 | — |
| 89bio Clinical Study Site | West Des Moines | Iowa | 50265 | — |
| 89Bio Clinical Study Site | Wichita | Kansas | 67205 | — |
| 89Bio Clinical Study Site | Marrero | Louisiana | 70072 | — |
| 89bio Clinical Trial Site | Shreveport | Louisiana | 71105 | — |
| 89Bio Clinical Study Site | Oxon Hill | Maryland | 20745 | — |
| 89bio Clinical Study Site | Flint | Michigan | 48504 | — |
| 89bio Clinical Trial Site | Kansas City | Missouri | 64131 | — |
| 89bio Clinical Study Site | St Louis | Missouri | 63110 | — |
| 89bio Clinical Study Site | Las Vegas | Nevada | 89106 | — |
| 89bio Clinical Study Site | Las Vegas | Nevada | 89118 | — |
| 89bio Clinical Study Sites | Sparta | New Jersey | 07871 | — |
| 89bio Clinical Study Site | East Syracuse | New York | 13057 | — |
| 89bio Clinical Trial Site | New Windsor | New York | 12553 | — |
| 89bio Clinical Trial Site | New York | New York | 10029 | — |
| 89Bio Clinical Study Site | North Massapequa | New York | 11758 | — |
| 89bio Clinical Trial Site | Richmond Hill | New York | 77379 | — |
| 89bio Clinical Trial Site | Syracuse | New York | 13057 | — |
| 89Bio Clinical Study Site | Morganton | North Carolina | 28655 | — |
| 89bio Clinical Study Site | Cincinnati | Ohio | 45227 | — |
| 89bio Clinical Trial Site | Columbus | Ohio | 43213 | — |
| 89bio Clinical Study Site | Middleburg Heights | Ohio | 44130 | — |
| 89bio Clinical Study Site | Stow | Ohio | 44224 | — |
| 89bio Clinical Study Site | Oklahoma City | Oklahoma | 73102 | — |
| 89Bio Clinical Study Site | Eugene | Oregon | 97404 | — |
| 89bio Clinical Study Site | Charleston | South Carolina | 29414 | — |
| 89Bio Clinical Study Site | Chattanooga | Tennessee | 37421 | — |
| 89bio Clinical Trial Site | Clarksville | Tennessee | 37040 | — |
| 89bio Clinical Study Site | Tullahoma | Tennessee | 37388 | — |
| 89bio Clinical Study Site | Amarillo | Texas | 79106 | — |
| 89 Clinical Study Site | Austin | Texas | 78757 | — |
| 89bio Clinical Study Site | Dallas | Texas | 75226 | — |
| 89bio Clinical Study Site | Graham | Texas | 76450 | — |
| 89bio Clinical Study Site | Houston | Texas | 77030 | — |
| 89Bio Clinical Study Site | Lampasas | Texas | 76550 | — |
| 89bio Clinical Study Site | Mansfield | Texas | 76063 | — |
| 89bio Clinical Trial Site | San Antonio | Texas | 78207 | — |
| 89bio Clinical Study Site | San Antonio | Texas | 78209 | — |
| 89bio Clinical Study Site | Wichita Falls | Texas | 76301 | — |
| 89bio Clinical Trial Site | Salt Lake City | Utah | 84107 | — |
| 89Bio Clinical Study Site | Burke | Virginia | 22015 | — |
| 89bio Clinical Trial Site | Richmond | Virginia | 23249 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 104 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05852431, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 7, 2026 · Synced Oct 26, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05852431 live on ClinicalTrials.gov.