ClinicalTrials.gov record
Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial
ClinicalTrials.gov ID: NCT05863195
Public ClinicalTrials.gov record NCT05863195. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Phase III Study of Systemic Therapy With or Without Hepatic Arterial Infusion for Unresectable Colorectal Liver Metastases: The PUMP Trial
Study identification
- NCT ID
- NCT05863195
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- ECOG-ACRIN Cancer Research Group
- Network
- Enrollment
- 408 participants
Conditions and interventions
Conditions
Interventions
- Bevacizumab Biological
- Cetuximab Biological
- Computed Tomography Procedure
- Floxuridine Drug
- Fluorouracil Drug
- Implantation Procedure
- Intrahepatic Infusion Procedure Procedure
- Irinotecan Drug
- Leucovorin Drug
- Oxaliplatin Drug
- Panitumumab Biological
- Single Photon Emission Computed Tomography Procedure
Biological · Procedure · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 18, 2023
- Primary completion
- Jun 29, 2029
- Completion
- Jun 29, 2034
- Last update posted
- May 14, 2026
2023 – 2034
United States locations
- U.S. sites
- 60
- U.S. states
- 20
- U.S. cities
- 50
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | 35233 | Withdrawn |
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | Recruiting |
| Banner-University Medical Center Phoenix | Phoenix | Arizona | 85006 | Recruiting |
| Banner Boswell Medical Center | Sun City | Arizona | 85351 | Recruiting |
| UCHealth University of Colorado Hospital | Aurora | Colorado | 80045 | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Aventura | Aventura | Florida | 33180 | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables | Florida | 33146 | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida | 33442 | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Hollywood | Hollywood | Florida | 33021 | Recruiting |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | 33136 | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Kendall | Miami | Florida | 33176 | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Plantation | Plantation | Florida | 33324 | Recruiting |
| Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | 30322 | Recruiting |
| Emory Saint Joseph's Hospital | Atlanta | Georgia | 30342 | Recruiting |
| Northwestern University | Chicago | Illinois | 60611 | Recruiting |
| University of Chicago Comprehensive Cancer Center | Chicago | Illinois | 60637 | Recruiting |
| Memorial Hospital East | Shiloh | Illinois | 62269 | Recruiting |
| IU Health North Hospital | Carmel | Indiana | 46032 | Recruiting |
| Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | 46202 | Recruiting |
| University of Kentucky/Markey Cancer Center | Lexington | Kentucky | 40536 | Recruiting |
| University of Michigan Rogel Cancer Center | Ann Arbor | Michigan | 48109 | Recruiting |
| Corewell Health Grand Rapids Hospitals - Butterworth Hospital | Grand Rapids | Michigan | 49503 | Recruiting |
| Mayo Clinic in Rochester | Rochester | Minnesota | 55905 | Recruiting |
| Siteman Cancer Center at Saint Peters Hospital | City of Saint Peters | Missouri | 63376 | Recruiting |
| Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri | 63141 | Recruiting |
| Washington University School of Medicine | St Louis | Missouri | 63110 | Recruiting |
| Siteman Cancer Center-South County | St Louis | Missouri | 63129 | Recruiting |
| Siteman Cancer Center at Christian Hospital | St Louis | Missouri | 63136 | Recruiting |
| Memorial Sloan Kettering Basking Ridge | Basking Ridge | New Jersey | 07920 | Recruiting |
| Memorial Sloan Kettering Monmouth | Middletown | New Jersey | 07748 | Recruiting |
| Memorial Sloan Kettering Bergen | Montvale | New Jersey | 07645 | Recruiting |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | Recruiting |
| Memorial Sloan Kettering Commack | Commack | New York | 11725 | Recruiting |
| Memorial Sloan Kettering Westchester | Harrison | New York | 10604 | Recruiting |
| Mount Sinai Hospital | New York | New York | 10029 | Recruiting |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | Recruiting |
| Memorial Sloan Kettering Nassau | Uniondale | New York | 11553 | Recruiting |
| Duke University Medical Center | Durham | North Carolina | 27710 | Recruiting |
| Duke Cancer Center Raleigh | Raleigh | North Carolina | 27609 | Recruiting |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | Recruiting |
| Case Western Reserve University | Cleveland | Ohio | 44106 | Active, not recruiting |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | Recruiting |
| Saint Elizabeth Youngstown Hospital | Youngstown | Ohio | 44501 | Recruiting |
| Oregon Health and Science University | Portland | Oregon | 97239 | Suspended |
| Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania | 18103 | Recruiting |
| Saint Vincent Hospital | Erie | Pennsylvania | 16544 | Recruiting |
| Jefferson Hospital | Jefferson Hills | Pennsylvania | 15025 | Recruiting |
| Forbes Hospital | Monroeville | Pennsylvania | 15146 | Recruiting |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | Recruiting |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | Recruiting |
| West Penn Hospital | Pittsburgh | Pennsylvania | 15224 | Recruiting |
| Wexford Health and Wellness Pavilion | Wexford | Pennsylvania | 15090 | Recruiting |
| Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | 37232 | Recruiting |
| Parkland Memorial Hospital | Dallas | Texas | 75235 | Recruiting |
| UT Southwestern Simmons Cancer Center - RedBird | Dallas | Texas | 75237 | Recruiting |
| UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | 75390 | Recruiting |
| UT Southwestern/Simmons Cancer Center-Fort Worth | Fort Worth | Texas | 76104 | Recruiting |
| UT Southwestern Clinical Center at Richardson/Plano | Richardson | Texas | 75080 | Recruiting |
| University of Wisconsin Carbone Cancer Center - Eastpark Medical Center | Madison | Wisconsin | 53718 | Recruiting |
| University of Wisconsin Carbone Cancer Center - University Hospital | Madison | Wisconsin | 53792 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05863195, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 14, 2026 · Synced May 21, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05863195 live on ClinicalTrials.gov.