Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial

ClinicalTrials.gov ID: NCT05863195

Public ClinicalTrials.gov record NCT05863195. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 12:28 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized Phase III Study of Systemic Therapy With or Without Hepatic Arterial Infusion for Unresectable Colorectal Liver Metastases: The PUMP Trial

Study identification

NCT ID: NCT05863195
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: ECOG-ACRIN Cancer Research Group; Network
Enrollment: 408 participants

Conditions and interventions

Conditions

Interventions

Bevacizumab Biological
Cetuximab Biological
Computed Tomography Procedure
Floxuridine Drug
Fluorouracil Drug
Implantation Procedure
Intrahepatic Infusion Procedure Procedure
Irinotecan Drug
Leucovorin Drug
Oxaliplatin Drug
Panitumumab Biological
Single Photon Emission Computed Tomography Procedure

Biological · Procedure · Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 18, 2023
Primary completion: Jun 29, 2029
Completion: Jun 29, 2034
Last update posted: May 4, 2026

2023 – 2034

United States locations

U.S. sites: 39
U.S. states: 17
U.S. cities: 33

Facility	City	State	ZIP	Site status
University of Alabama at Birmingham Cancer Center	Birmingham	Alabama	35233	Recruiting
UCHealth University of Colorado Hospital	Aurora	Colorado	80045	Recruiting
UM Sylvester Comprehensive Cancer Center at Aventura	Aventura	Florida	33180	Recruiting
UM Sylvester Comprehensive Cancer Center at Coral Gables	Coral Gables	Florida	33146	Recruiting
UM Sylvester Comprehensive Cancer Center at Deerfield Beach	Deerfield Beach	Florida	33442	Recruiting
UM Sylvester Comprehensive Cancer Center at Hollywood	Hollywood	Florida	33021	Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center	Miami	Florida	33136	Recruiting
UM Sylvester Comprehensive Cancer Center at Kendall	Miami	Florida	33176	Recruiting
UM Sylvester Comprehensive Cancer Center at Plantation	Plantation	Florida	33324	Recruiting
Emory University Hospital/Winship Cancer Institute	Atlanta	Georgia	30322	Recruiting
University of Chicago Comprehensive Cancer Center	Chicago	Illinois	60637	Recruiting
Memorial Hospital East	Shiloh	Illinois	62269	Recruiting
IU Health North Hospital	Carmel	Indiana	46032	Recruiting
Indiana University/Melvin and Bren Simon Cancer Center	Indianapolis	Indiana	46202	Recruiting
University of Kentucky/Markey Cancer Center	Lexington	Kentucky	40536	Recruiting
University of Michigan Comprehensive Cancer Center	Ann Arbor	Michigan	48109	Recruiting
Corewell Health Grand Rapids Hospitals - Butterworth Hospital	Grand Rapids	Michigan	49503	Recruiting
Mayo Clinic in Rochester	Rochester	Minnesota	55905	Recruiting
Siteman Cancer Center at Saint Peters Hospital	City of Saint Peters	Missouri	63376	Recruiting
Siteman Cancer Center at West County Hospital	Creve Coeur	Missouri	63141	Recruiting
Washington University School of Medicine	St Louis	Missouri	63110	Recruiting
Siteman Cancer Center-South County	St Louis	Missouri	63129	Recruiting
Siteman Cancer Center at Christian Hospital	St Louis	Missouri	63136	Recruiting
Memorial Sloan Kettering Basking Ridge	Basking Ridge	New Jersey	07920	Recruiting
Memorial Sloan Kettering Monmouth	Middletown	New Jersey	07748	Recruiting
Memorial Sloan Kettering Bergen	Montvale	New Jersey	07645	Recruiting
Memorial Sloan Kettering Commack	Commack	New York	11725	Recruiting
Memorial Sloan Kettering Westchester	East White Plains	New York	10604	Recruiting
Mount Sinai Hospital	New York	New York	10029	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
Memorial Sloan Kettering Nassau	Uniondale	New York	11553	Recruiting
Duke University Medical Center	Durham	North Carolina	27710	Recruiting
Case Western Reserve University	Cleveland	Ohio	44106	Active, not recruiting
Fox Chase Cancer Center	Philadelphia	Pennsylvania	19111	Recruiting
Allegheny General Hospital	Pittsburgh	Pennsylvania	15212	Recruiting
West Penn Hospital	Pittsburgh	Pennsylvania	15224	Recruiting
Vanderbilt University/Ingram Cancer Center	Nashville	Tennessee	37232	Recruiting
Parkland Memorial Hospital	Dallas	Texas	75235	Recruiting
UT Southwestern/Simmons Cancer Center-Dallas	Dallas	Texas	75390	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05863195, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 4, 2026 · Synced May 8, 2026

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The complete protocol, eligibility criteria, and contact information for NCT05863195 live on ClinicalTrials.gov.

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