A Dose Escalation Study of AV-380 in Cancer Patients With Cachexia
Public ClinicalTrials.gov record NCT05865535. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1B Dose Escalation Study of AV-380 in Combination With Standard of Care Chemotherapy in Metastatic Cancer Patients With Cachexia and Elevated GDF-15 Levels
Study identification
- NCT ID
- NCT05865535
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1
- Lead sponsor
- AVEO Pharmaceuticals, Inc.
- Industry
- Enrollment
- 30 participants
Conditions and interventions
Conditions
Interventions
- AV-380 Biological
Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 12, 2023
- Primary completion
- Nov 30, 2026
- Completion
- Dec 30, 2026
- Last update posted
- Jan 7, 2026
2023 – 2026
United States locations
- U.S. sites
- 12
- U.S. states
- 10
- U.S. cities
- 12
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Beverly Hills Cancer Center | Beverly Hills | California | 90211 | Recruiting |
| Cancer and Blood Specialty Clinic | Lakewood | California | 90712 | Recruiting |
| Hoag Memorial Hospital | Newport Beach | California | 92663 | Recruiting |
| Hartford Hospital | Hartford | Connecticut | 06102 | Recruiting |
| Advent Health Orlando Hospital | Orlando | Florida | 32804 | Recruiting |
| Nebraska Cancer Specialists | Omaha | Nebraska | 68130 | Recruiting |
| Astera Cancer Care | East Brunswick | New Jersey | 08816 | Recruiting |
| New York Cancer And Blood Specialists | Shirley | New York | 11967 | Recruiting |
| Oregon Health and Science University | Portland | Oregon | 97239 | Recruiting |
| MUSC Hollings Cancer Center | Charleston | South Carolina | 29425 | Recruiting |
| Vanderbilt University Henry-Joyce Cancer Clinic | Nashville | Tennessee | 37232 | Recruiting |
| Community Clinical Trials | Kingwood | Texas | 77339 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05865535, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 7, 2026 · Synced May 16, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05865535 live on ClinicalTrials.gov.