A Study of NT-175 in Adult Subjects With Unresectable, Advanced, and/or Metastatic Solid Tumors That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

ClinicalTrials.gov ID: NCT05877599

Public ClinicalTrials.gov record NCT05877599. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 8:11 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

An Open-label, Phase 1, Multicenter Study to Evaluate the Safety and Preliminary Anti-tumor Activity of NT-175 in Human Leukocyte Antigen-A*02:01-Positive Adult Subjects With Unresectable, Advanced and/or Metastatic Solid Tumors That Are Positive for the TP53 R175H Mutation

Study identification

NCT ID: NCT05877599
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1
Lead sponsor: AstraZeneca; Industry
Enrollment: 45 participants

Conditions and interventions

Conditions

Interventions

Autologous, engineered T Cells targeting TP53 R175H Biological

Biological

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jul 11, 2023
Primary completion: Aug 31, 2028
Completion: Jul 30, 2029
Last update posted: Apr 14, 2026

2023 – 2029

United States locations

U.S. sites: 18
U.S. states: 12
U.S. cities: 18

Facility	City	State	ZIP	Site status
Research Site	Gilbert	Arizona	85234	Recruiting
Research Site	Duarte	California	91010	Recruiting
Research Site	Newport Beach	California	92663	Recruiting
Research Site	Santa Monica	California	90404	Recruiting
Research Site	Jacksonville	Florida	32224	Recruiting
Research Site	Miami	Florida	33136	Withdrawn
Research Site	Tampa	Florida	33612	Withdrawn
Research Site	Boston	Massachusetts	02115	Recruiting
Research Site	New Brunswick	New Jersey	08901	Recruiting
Research Site	New York	New York	10065	Recruiting
Research Site	Charlotte	North Carolina	28204	Withdrawn
Research Site	Winston-Salem	North Carolina	27103	Withdrawn
Research Site	Portland	Oregon	97213	Recruiting
Research Site	Pittsburgh	Pennsylvania	15232	Recruiting
Research Site	Nashville	Tennessee	37203	Recruiting
Research Site	Houston	Texas	77030	Recruiting
Research Site	Round Rock	Texas	78665	Recruiting
Research Site	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05877599, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 14, 2026 · Synced May 6, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05877599 live on ClinicalTrials.gov.

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