A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease
Public ClinicalTrials.gov record NCT05882045. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Phase 3 Study to Investigate the Efficacy and Safety of LY3437943 Once Weekly Compared to Placebo in Participants With Severe Obesity and Established Cardiovascular Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main purpose of this study is to evaluate the efficacy and safety of retatrutide once weekly in participants with obesity and established cardiovascular disease (CVD). The study will last about 113 weeks.
Study identification
- NCT ID
- NCT05882045
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,946 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 30, 2023 (Actual)
- Primary completion
- Apr 16, 2026 (Actual)
- Completion
- May 14, 2026 (Actual)
- Last update posted
- Jul 30, 2026
2023 – 2026
United States locations
- U.S. sites
- 46
- U.S. states
- 22
- U.S. cities
- 42
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Central Phoenix Medical Clinic | Phoenix | Arizona | 85020 | — |
| Valley Clinical Trials, Inc. | Covina | California | 91723 | — |
| Neuro-Pain Medical Center | Fresno | California | 93710 | — |
| Valley Research | Fresno | California | 93720 | — |
| Collaborative Neuroscience Research, LLC | Los Alamitos | California | 90720 | — |
| Velocity Clinical Research, Westlake | Los Angeles | California | 90057 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| Velocity Clinical Research, Panorama City | Van Nuys | California | 91405 | — |
| Chase Medical Research, LLC | Waterbury | Connecticut | 06708 | — |
| Indago Research & Health Center, Inc | Hialeah | Florida | 33012 | — |
| Clinical Neuroscience Solutions, Inc. dba CNS Healthcare | Jacksonville | Florida | 32256 | — |
| Clinical Neuroscience Solutions, Inc. | Orlando | Florida | 32801 | — |
| Charter Research - Winter Park | Orlando | Florida | 32803 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| Pacific Diabetes & Endocrine Center | Honolulu | Hawaii | 96817 | — |
| Elite Clinical Trials | Blackfoot | Idaho | 83221 | — |
| Humphreys Diabetes Center | Boise | Idaho | 83702 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Great Lakes Clinical Trials - Gurnee | Gurnee | Illinois | 60031 | — |
| Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative | Springfield | Illinois | 62711 | — |
| Brengle Family Medicine | Indianapolis | Indiana | 46260 | — |
| Iowa Diabetes and Endocrinology Research Center | West Des Moines | Iowa | 50265 | — |
| Cotton O'Neil Diabetes & Endocrinology | Topeka | Kansas | 66606 | — |
| MedVadis Research Corporation | Waltham | Massachusetts | 02451 | — |
| StudyMetrix Research | City of Saint Peters | Missouri | 63303 | — |
| Las Vegas Medical Research | Las Vegas | Nevada | 89128 | — |
| Palm Research Center Tenaya | Las Vegas | Nevada | 89128 | — |
| IMA Clinical Research Warren | Warren Township | New Jersey | 07059 | — |
| Weill Cornell Medical College | New York | New York | 10021 | — |
| Rochester Clinical Research, LLC | Rochester | New York | 14609 | — |
| Carteret Medical Group | Morehead City | North Carolina | 28557 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Altoona Center For Clinical Research | Duncansville | Pennsylvania | 16635 | — |
| UPMC Montefiore University Hospital | Pittsburgh | Pennsylvania | 15213 | — |
| Tribe Clinical Research, LLC | Greenville | South Carolina | 29607 | — |
| Trial Management Associates | Myrtle Beach | South Carolina | 29572 | — |
| Tribe Clinical Research - Spartanburg | Spartanburg | South Carolina | 29301 | — |
| Texas Diabetes & Endocrinology, P.A. | Austin | Texas | 78731 | — |
| Pinnacle Clinical Research | Austin | Texas | 78757 | — |
| South Texas Clinical Research | Corpus Christi | Texas | 78404 | — |
| Southern Endocrinology Associates | Mesquite | Texas | 75149 | — |
| Texas Diabetes & Endocrinology, P.A. | Round Rock | Texas | 78681 | — |
| Sleep Therapy Research Center | San Antonio | Texas | 78229 | — |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | — |
| Advanced Research Institute | Ogden | Utah | 84405 | — |
| Rainier Clinical Research Center | Renton | Washington | 98057 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 123 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05882045, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 30, 2026 · Synced Oct 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05882045 live on ClinicalTrials.gov.