Study to Investigate the Effect of Rocatinlimab (AMG 451) on the Pharmacokinetics of Multiple Cytochrome P450 (CYP450) Substrates in Participants With Moderate to Severe Atopic Dermatitis
Public ClinicalTrials.gov record NCT05891119. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1, Open-label, Drug-Drug Interaction Study to Investigate the Effect of Rocatinlimab (AMG 451) on the Pharmacokinetics of Multiple CYP450 Substrates in Patients With Moderate to Severe Atopic Dermatitis
Study identification
- NCT ID
- NCT05891119
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Early Phase 1
- Lead sponsor
- Amgen
- Industry
- Enrollment
- 21 participants
Conditions and interventions
Conditions
Interventions
- Caffeine Dietary Supplement
- Metoprolol Drug
- Midazolam Drug
- Omeprazole Drug
- Rocatinlimab Drug
- Vitamin K Dietary Supplement
- Warfarin Drug
Dietary Supplement · Drug
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 2, 2023
- Primary completion
- Aug 27, 2024
- Completion
- Feb 11, 2025
- Last update posted
- Dec 22, 2025
2023 – 2025
United States locations
- U.S. sites
- 7
- U.S. states
- 6
- U.S. cities
- 7
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Velocity Clinical Research, North Hollywood | North Hollywood | California | 91606-1570 | — |
| Accel Research Sites (ACR) | DeLand | Florida | 32720-3134 | — |
| Direct Helpers Research Center (DHRC) | Hialeah | Florida | 33012-3618 | — |
| Axis Clinicals, LCC | Dilworth | Minnesota | 56529 | — |
| DermDox Dermatology Centers, PC - Camp Hill | Camp Hill | Pennsylvania | 17011 | — |
| Velocity Clinical Research -Spartanburg | Spartanburg | South Carolina | 29303-4225 | — |
| DermDox Dermatology Centers, PC - Sugarloaf | Nashville | Tennessee | 37203-1632 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05891119, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 22, 2025 · Synced May 4, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05891119 live on ClinicalTrials.gov.