A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

ClinicalTrials.gov ID: NCT05920356

Public ClinicalTrials.gov record NCT05920356. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 4, 2026, 7:11 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Multicenter, Randomized, Open-label Study Evaluating Efficacy of Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Subjects With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers, Negative for PD-L1, and Positive for KRAS p.G12C (CodeBreaK 202)

Study identification

NCT ID: NCT05920356
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Amgen; Industry
Enrollment: 750 participants

Conditions and interventions

Conditions

Non-Small Cell Lung Cancer (NSCLC)

Interventions

Pembrolizumab Drug
Sotorasib Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 100 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Nov 15, 2023
Primary completion: Jun 29, 2027
Completion: Jun 28, 2032
Last update posted: Apr 30, 2026

2023 – 2032

United States locations

U.S. sites: 18
U.S. states: 11
U.S. cities: 16

Facility	City	State	ZIP	Site status
Sansum Clinic	Santa Barbara	California	93105	Recruiting
Medical Oncology Hematology Consultants Helen F Graham Cancer Center	Newark	Delaware	19713	Recruiting
University of Illinois Chicago	Chicago	Illinois	60612	Recruiting
Illinois Cancer Specialists	Niles	Illinois	60714	Recruiting
Norton Cancer Institute - Brownsboro	Louisville	Kentucky	40241	Completed
Reliant Medical Group Inc	Worcester	Massachusetts	01606	Recruiting
University of New Mexico Cancer Center	Albuquerque	New Mexico	87131	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Terminated
Duke University	Durham	North Carolina	27710	Recruiting
FirstHealth Cancer Center	Pinehurst	North Carolina	28374	Recruiting
Alliance Cancer Specialists - Media	Media	Pennsylvania	19063	Recruiting
University of Pittsburgh Medical Center	Pittsburgh	Pennsylvania	15232	Terminated
Regional One Health	Memphis	Tennessee	38103	Recruiting
Sarah Cannon Research Institute	Nashville	Tennessee	37203	Recruiting
United States Oncology Regulatory Affairs Corporate Office	Nashville	Tennessee	37203	Recruiting
Oncology Consultants PA	Houston	Texas	77030	Recruiting
University of Texas MD Anderson Cancer Center	Houston	Texas	77030	Recruiting
US Oncology Research Investigational Products Center	Irving	Texas	75063	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 362 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05920356, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 30, 2026 · Synced May 4, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05920356 live on ClinicalTrials.gov.

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