A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia
Public ClinicalTrials.gov record NCT05926765. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled Study to Determine the Efficacy and Safety of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will assess the efficacy and safety of bilateral intra-parotid administration of AAV2-hAQP1 in adults with Grade 2 or Grade 3 radiation-induced late xerostomia.
Study identification
- NCT ID
- NCT05926765
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 290 participants
Conditions and interventions
Interventions
- AAV2-hAQP1 Concentration 1 Genetic
- AAV2-hAQP1 Concentration 2 Genetic
- Placebo Other
- AAV2-hAQP1 Concentration 3 Genetic
- AAV2-hAQP1 Concentration 4 Genetic
Genetic · Other
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 13, 2023 (Actual)
- Primary completion
- Jun 2027 (Estimated)
- Completion
- Jun 2027 (Estimated)
- Last update posted
- Jul 24, 2026
2023 – 2027
United States locations
- U.S. sites
- 18
- U.S. states
- 13
- U.S. cities
- 17
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | — |
| City of Hope | Duarte | California | 91010 | — |
| Miami Cancer Institute at Baptist Health South Florida | Miami | Florida | 33176 | — |
| University of Iowa | Iowa City | Iowa | 52242 | — |
| Johns Hopkins Hospital | Baltimore | Maryland | 21231 | — |
| Tufts University School of Dental Medicine | Boston | Massachusetts | 02111 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02120 | — |
| Henry Ford Health | Detroit | Michigan | 48202 | — |
| University of Missouri | Columbia | Missouri | 65212 | — |
| Washington University - St. Louis | St Louis | Missouri | 63110 | — |
| Erie County Medical Center | Buffalo | New York | 14215 | — |
| UNC-Chapel Hill | Chapel Hill | North Carolina | 27514 | — |
| Atrium Health | Charlotte | North Carolina | 28203 | — |
| Penn State | Hershey | Pennsylvania | 17033 | — |
| Alleghany General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| Johnson City Medical Center | Johnson City | Tennessee | 37604 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Houston Methodist | Houston | Texas | 77030 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 15 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05926765, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 24, 2026 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05926765 live on ClinicalTrials.gov.