A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight
Public ClinicalTrials.gov record NCT05929066. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Master Protocol to Investigate the Efficacy and Safety of LY3437943 Once Weekly in Participants Without Type 2 Diabetes Who Have Obesity or Overweight: A Randomized, Double-Blind, Placebo-Controlled Trial (TRIUMPH-1)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the efficacy and safety of retatrutide in participants who have obesity or overweight (J1I-MC-GZBJ master protocol) including subsets of participants who have knee osteoarthritis (OA) (J1I-MC-GOA1) or who have obstructive sleep apnea (OSA) (J1I-MC-GSA1). This study will last about 89 weeks and will include up to 24 visits. Addendum (2) is optional and available to approximately 500 participants to continue treatment with retatrutide for up to an additional 24 weeks.
Study identification
- NCT ID
- NCT05929066
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 2,335 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 10, 2023 (Actual)
- Primary completion
- Apr 6, 2026 (Actual)
- Completion
- Apr 30, 2026 (Actual)
- Last update posted
- Aug 21, 2026
2023 – 2026
United States locations
- U.S. sites
- 39
- U.S. states
- 24
- U.S. cities
- 36
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Central Phoenix Medical Clinic | Phoenix | Arizona | 85020 | — |
| Arizona Research Center | Phoenix | Arizona | 85053 | — |
| Medical Investigations | Little Rock | Arkansas | 72211 | — |
| Neuro-Pain Medical Center | Fresno | California | 93710 | — |
| Valley Research | Fresno | California | 93720 | — |
| Artemis Institute for Clinical Research | San Diego | California | 92103 | — |
| University of Colorado Anschutz Medical Campus | Aurora | Colorado | 80045 | — |
| Yale University School of Medicine | New Haven | Connecticut | 06519 | — |
| Chase Medical Research, LLC | Waterbury | Connecticut | 06708 | — |
| Teradan Clinical Trials, LLC | Brandon | Florida | 33511 | — |
| Suncoast Research Group | Miami | Florida | 33135 | — |
| New Horizon Research Center | Miami | Florida | 33165 | — |
| Clinical Neuroscience Solutions | Orlando | Florida | 32801 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| NeuroTrials Research Inc | Atlanta | Georgia | 30328 | — |
| North Georgia Clinical Research | Woodstock | Georgia | 30189 | — |
| East-West Medical Research Institute | Honolulu | Hawaii | 96814 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative | Springfield | Illinois | 62711 | — |
| Brengle Family Medicine | Indianapolis | Indiana | 46260 | — |
| Cotton O'Neil Diabetes & Endocrinology | Topeka | Kansas | 66606 | — |
| MedVadis Research Corporation | Waltham | Massachusetts | 02451 | — |
| Great Lakes Research Group, Inc. | Bay City | Michigan | 48706 | — |
| StudyMetrix Research | City of Saint Peters | Missouri | 63303 | — |
| Clinvest Research LLC | Springfield | Missouri | 65807 | — |
| Palm Research Center Tenaya | Las Vegas | Nevada | 89128 | — |
| Rochester Clinical Research, LLC | Rochester | New York | 14609 | — |
| Carteret Medical Group | Morehead City | North Carolina | 28557 | — |
| Trial Management Associates - Wilmington - Floral Parkway | Wilmington | North Carolina | 28403 | — |
| Lillestol Research | Fargo | North Dakota | 58104 | — |
| Altoona Center For Clinical Research | Duncansville | Pennsylvania | 16635 | — |
| Tribe Clinical Research, LLC | Greenville | South Carolina | 29607 | — |
| Tribe Clinical Research - Spartanburg | Spartanburg | South Carolina | 29301 | — |
| Vanderbilt Health One Hundred Oaks | Nashville | Tennessee | 37204 | — |
| FutureSearch Trials of Neurology | Austin | Texas | 78731 | — |
| Juno Research | Houston | Texas | 77040 | — |
| Advanced Research Institute | Ogden | Utah | 84405 | — |
| Northwest Clinical Research Center | Bellevue | Washington | 98007 | — |
| Rainier Clinical Research Center | Renton | Washington | 98057 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 95 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05929066, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 21, 2026 · Synced Oct 31, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05929066 live on ClinicalTrials.gov.