The Fourth Left Atrial Appendage Occlusion Study

ClinicalTrials.gov ID: NCT05963698

Public ClinicalTrials.gov record NCT05963698. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 22, 2026, 12:56 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

The Fourth Left Atrial Appendage Occlusion Study (LAAOS-4)

Study identification

NCT ID: NCT05963698
Recruitment status: Recruiting
Study type: Interventional
Phase: Not applicable
Lead sponsor: Hamilton Health Sciences Corporation; Other
Enrollment: 4,000 participants

Conditions and interventions

Conditions

Interventions

WATCHMAN device Device

Device

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Not listed

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Nov 29, 2023
Primary completion: Aug 31, 2029
Completion: Nov 30, 2029
Last update posted: Mar 11, 2026

2023 – 2029

United States locations

U.S. sites: 47
U.S. states: 28
U.S. cities: 45

Facility	City	State	ZIP	Site status
Affinity Hospital dba Grandview Medical Center	Birmingham	Alabama	35243	Withdrawn
Arrhythmia Research Group	Jonesboro	Arkansas	72401	Recruiting
Memorial Health Services	Fountain Valley	California	92708	Recruiting
Loma Linda University Health	Loma Linda	California	92354	Recruiting
Southern California Permanente Medical Group	Pasadena	California	91101	Recruiting
Sutter Valley Hospitals dba Sutter Institute for Medical Research	Sacramento	California	95816	Recruiting
JFK Medical Center Limited Partnership d/b/a HCA Florida JFK Hospital	Atlantis	Florida	33462	Recruiting
St. Vincent's Health System	Jacksonville	Florida	32204	Recruiting
Largo Medical Center, Inc. d/b/a HCA Florida Largo Medical Center	Largo	Florida	33770	Recruiting
The University of South Florida	Tampa	Florida	33620	Recruiting
Emory University	Atlanta	Georgia	30322	Recruiting
St Luke's Regional Medical Center, Ltd	Boise	Idaho	83712	Recruiting
Kootenai Health Inc.	Coeur d'Alene	Idaho	83814	Recruiting
Northwestern University	Evanston	Illinois	60208	Recruiting
Cardiovascular Medicine, PLLC and Unity Point Trinity Rock Island	Rock Island	Illinois	61201	Recruiting
Community Health Network Inc.	Indianapolis	Indiana	46256	Recruiting
MercyOne Iowa Heart Center	West Des Moines	Iowa	50266	Recruiting
University of Kansas Medical Center Research Institute, Inc.	Kansas City	Kansas	66160	Recruiting
Babtist Health Lexington	Lexington	Kentucky	40503	Recruiting
Ochsner Clinic Foundation	New Orleans	Louisiana	70121	Recruiting
University of Maryland Baltimore	Baltimore	Maryland	21201	Recruiting
Lahey Clinic Inc.	Burlington	Massachusetts	01805	Recruiting
University of Michigan	Ann Arbor	Michigan	48109	Recruiting
Henry Ford Health System	Detroit	Michigan	48202	Recruiting
Mayo Clinic	Rochester	Minnesota	55905	Recruiting
Hackensack University Medical Center	Hackensack	New Jersey	07601	Recruiting
The Feinstein Institutes for Medical Research	Manhasset	New York	11030	Recruiting
Cornell University for and on behalf of its Joan & Sanford I. Weill Medical College and The New York Presbyterian Hospital	New York	New York	10065	Recruiting
NYU Grossman School of Medicine	New York	New York	10065	Withdrawn
Mission Hospital HCA	Asheville	North Carolina	28801	Recruiting
Aultman Hospital	Canton	Ohio	44710	Recruiting
TriHealth Inc.	Cincinnati	Ohio	45202	Recruiting
University of Cincinnati	Cincinnati	Ohio	45221	Recruiting
Cleveland Clinic	Cleveland	Ohio	44195	Recruiting
Saint Francis Hospital	Tulsa	Oklahoma	74136	Recruiting
The Pennsylvania State University and The Milton S. Hershey Medical Center	Hershey	Pennsylvania	17033	Recruiting
The Trustees of the University of Pennsylvania	Philadelphia	Pennsylvania	19104	Recruiting
University of Pittsburgh Medical Center (UPMC) Presbyterian Heart and Vascular Institute	Pittsburgh	Pennsylvania	15213	Recruiting
Rhode Island Hospital	Providence	Rhode Island	02903	Recruiting
Glanecare, Inc. d/b/a HCA Florida Brandon Hospital	Brentwood	Tennessee	37027	Recruiting
Texas Cardiac Arrhythmia Research Foundation	Austin	Texas	78705	Withdrawn
Baylor Research Institute	Dallas	Texas	75204	Recruiting
Heart Rhythm Associates	The Woodlands	Texas	77380	Withdrawn
CHRISTUS Northeast Texas Health System	Tyler	Texas	75701-2263	Recruiting
The Rector and Visitors of the University of Virginia	Charlottesville	Virginia	22903	Recruiting
CommonSpirit Health Research Institute	Tacoma	Washington	98405	Recruiting
The Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 78 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05963698, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Mar 11, 2026 · Synced Apr 22, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05963698 live on ClinicalTrials.gov.

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