A Study to Evaluate the Safety and Efficacy of NEXAGON® (Lufepirsen Ophthalmic Gel) in Subjects With PCED
Public ClinicalTrials.gov record NCT05966493. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Multicenter, Double-Masked, Vehicle-Controlled Phase 2 Study to Evaluate the Safety and Efficacy of NEXAGON® (Lufepirsen Ophthalmic Gel) in Subjects With Persistent Corneal Epithelial Defects (NEXPEDE-1)
Study identification
- NCT ID
- NCT05966493
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Glaukos Corporation
- Industry
- Enrollment
- 84 participants
Conditions and interventions
Conditions
Interventions
- Vehicle Drug
- lufepirsen high dose Drug
- lufepirsen low dose Drug
Drug
Eligibility (public fields only)
- Age range
- 2 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 16, 2023
- Primary completion
- Nov 30, 2025
- Completion
- Nov 30, 2025
- Last update posted
- Jul 23, 2025
2023 – 2025
United States locations
- U.S. sites
- 21
- U.S. states
- 14
- U.S. cities
- 20
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Glaukos Investigative Site | Dothan | Alabama | 36301 | Recruiting |
| Glaukos Investigative Site | Petaluma | California | 94954 | Recruiting |
| Glaukos Investigative Site | Torrance | California | 90505 | Recruiting |
| Glaukos Investigative Site | Colorado Springs | Colorado | 80924 | Recruiting |
| Glaukos Investigative Site | Grand Junction | Colorado | 81501 | Recruiting |
| Glaukos Investigative Site | Bradenton | Florida | 34209 | Recruiting |
| Glaukos Investigative Site | Fort Myers | Florida | 33907 | Recruiting |
| Glaukos Investigative Site | South Miami | Florida | 33143 | Recruiting |
| Glaukos Investigative Site | Atlanta | Georgia | 30339 | Recruiting |
| Glaukos Investigative Site | Carmel | Indiana | 46032 | Recruiting |
| Glaukos Investigative Site | Fraser | Michigan | 48026 | Recruiting |
| Glaukos Investigative Site | Kansas City | Missouri | 64133 | Recruiting |
| Glaukos Investigative Site | Kansas City | Missouri | 64154 | Recruiting |
| Glaukos Investigative Site | Palisades Park | New Jersey | 07650 | Recruiting |
| Glaukos Investigative Site | Shelby | North Carolina | 28150 | Recruiting |
| Glaukos Investigative Site | Bala-Cynwyd | Pennsylvania | 19004 | Recruiting |
| Glaukos Investigative Site | Nashville | Tennessee | 37215 | Recruiting |
| Glaukos Investigative Site | Houston | Texas | 77025 | Recruiting |
| Glaukos Investigative Site | San Antonio | Texas | 78209 | Recruiting |
| Glaukos Investigative Site | Madison | Wisconsin | 53705 | Recruiting |
| Glaukos Investigative Site | Milwaukee | Wisconsin | 53226 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05966493, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 23, 2025 · Synced May 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05966493 live on ClinicalTrials.gov.