A Study of Zipalertinib in Patients With Advanced Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions or Other Uncommon Mutation.
Public ClinicalTrials.gov record NCT05967689. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-Label, Phase 2b, Global Multicenter Cohort Trial to Assess the Safety and Efficacy of Zipalertinib in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer With Exon 20 Insertion and Uncommon/Single or Compound Epidermal Growth Factor Receptor Mutations.
Study identification
- NCT ID
- NCT05967689
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Taiho Oncology, Inc.
- Industry
- Enrollment
- 220 participants
Conditions and interventions
Interventions
- CYP Cocktail Drug
- TAS6417 Drug
- Transporter Cocktail Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 30, 2023
- Primary completion
- Aug 30, 2028
- Completion
- Dec 30, 2028
- Last update posted
- Apr 2, 2026
2023 – 2028
United States locations
- U.S. sites
- 18
- U.S. states
- 11
- U.S. cities
- 18
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | Withdrawn |
| City of Hope - Duarte | Duarte | California | 91010 | Recruiting |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | Recruiting |
| Comprehensive Cancer Centers of Nevada - Central Valley - Twain | Las Vegas | Nevada | 89169 | Recruiting |
| Memorial Sloan Kettering Cancer Center - Basking Ridge | Basking Ridge | New Jersey | 07920 | Recruiting |
| Memorial Sloan Kettering Cancer Center - Monmouth | Middletown | New Jersey | 07748 | Recruiting |
| Memorial Sloan Kettering Cancer Center - Bergen | Montvale | New Jersey | 07645 | Recruiting |
| Memorial Sloan Kettering Cancer Center - Commack | Commack | New York | 11725 | Recruiting |
| Memorial Sloan Kettering Cancer Center - Westchester | Harrison | New York | 10604 | Recruiting |
| MSK Cancer Center | Long Island City | New York | 11101 | Recruiting |
| Memorial Sloan Kettering Cancer Center - Nassau | Uniondale | New York | 11553 | Recruiting |
| Gabrail Cancer and Research Center | Canton | Ohio | 44718 | Active, not recruiting |
| Zangmeister Cancer Center | Columbus | Ohio | 43219 | Withdrawn |
| The Toledo Clinic Cancer Center | Toledo | Ohio | 43623 | Withdrawn |
| SCRI Oncology Partners | Nashville | Tennessee | 37203 | Recruiting |
| University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
| Virginia Cancer Specialists | Fairfax | Virginia | 22031 | Recruiting |
| IDS Pharmacy | Milwaukee | Wisconsin | 53226 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 62 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05967689, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 2, 2026 · Synced May 19, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05967689 live on ClinicalTrials.gov.