Study to Evaluate Efficacy and Safety of Romosozumab Compared With Bisphosphonates in Children and Adolescents With Osteogenesis Imperfecta

ClinicalTrials.gov ID: NCT05972551

Public ClinicalTrials.gov record NCT05972551. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 2, 2026, 7:09 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Open-Label, Multicenter, Randomized Study to Evaluate Efficacy and Safety of Romosozumab Compared With Bisphosphonates in Children and Adolescents With Osteogenesis Imperfecta

Study identification

NCT ID: NCT05972551
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Amgen; Industry
Enrollment: 106 participants

Conditions and interventions

Conditions

Osteogenesis Imperfecta

Interventions

Bisphosphonate Drug
Romosozumab Drug

Drug

Eligibility (public fields only)

Age range: 5 Years to 17 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Apr 21, 2024
Primary completion: May 31, 2027
Completion: Aug 24, 2027
Last update posted: Apr 30, 2026

2024 – 2027

United States locations

U.S. sites: 14
U.S. states: 12
U.S. cities: 14

Facility	City	State	ZIP	Site status
Childrens Hospital of Alabama	Birmingham	Alabama	35233	Terminated
Phoenix Childrens Hospital	Phoenix	Arizona	85016	Recruiting
University of California, Los Angeles Interventional Clinical Trials	Los Angeles	California	90095	Recruiting
Nemours Hospital for Children	Wilmington	Delaware	19803	Recruiting
Nemours Childrens Hospital	Orlando	Florida	32827	Recruiting
University of South Florida - Carol and Frank Morsani Center for Advanced Health Care	Tampa	Florida	33606	Recruiting
Emory University	Atlanta	Georgia	30322	Terminated
Indiana University	Indianapolis	Indiana	46202	Recruiting
Kennedy Krieger Institute	Baltimore	Maryland	21287	Recruiting
Boston Childrens Hospital	Boston	Massachusetts	02115	Recruiting
Mayo Clinic Childrens Center	Rochester	Minnesota	55905	Terminated
Gillette Childrens Hospital and Clinic Saint Paul	Saint Paul	Minnesota	55101	Recruiting
Vanderbilt University Medical Center	Nashville	Tennessee	37212-3157	Recruiting
Marshfield Clinic	Marshfield	Wisconsin	54449	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 51 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05972551, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 30, 2026 · Synced May 2, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05972551 live on ClinicalTrials.gov.

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