A Study of Disitamab Vedotin in Previously Treated Solid Tumors That Express HER2
Public ClinicalTrials.gov record NCT06003231. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Basket Study of Disitamab Vedotin in Adult Subjects With Previously Treated, Locally-Advanced Unresectable or Metastatic Solid Tumors That Express HER2
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This clinical trial is studying advanced or metastatic solid tumors. Once a solid tumor has grown very large in one spot or has spread to other places in the body, it is called advanced or metastatic cancer. Participants in this study must have head and neck cancer, non-small cell lung cancer, endometrial cancer, or ovarian cancer. In the first part of the study, participants must have tumors that have a marker called HER2. This clinical trial uses an experimental drug called disitamab vedotin (DV). DV is a type of antibody-drug conjugate or ADC. ADCs are designed to stick to cancer cells and kill them. In this study, all participants will get DV once every 2 weeks. This study is being done to see if DV works to treat different types of solid tumors that express HER2. It will also test how safe the drug is for participants. This trial will also study what side effects happen when participants get the drug. A side effect is anything a drug does to your body besides treating the disease.
Study identification
- NCT ID
- NCT06003231
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 120 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 14, 2023 (Actual)
- Primary completion
- Mar 27, 2026 (Actual)
- Completion
- May 31, 2028 (Estimated)
- Last update posted
- Jul 22, 2026
2023 – 2028
United States locations
- U.S. sites
- 75
- U.S. states
- 15
- U.S. cities
- 39
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers | Chandler | Arizona | 85224 | — |
| Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers | Gilbert | Arizona | 85297 | — |
| Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers | Glendale | Arizona | 85306 | — |
| Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers | Mesa | Arizona | 85202 | — |
| Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers | Mesa | Arizona | 85206 | — |
| Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers | Phoenix | Arizona | 85028 | — |
| Ironwood Physicians P.C. dba Ironwood Cancer and Research Centers | Scottsdale | Arizona | 85260 | — |
| Valkyrie Clinical Trials(Additional Suite) | Los Angeles | California | 90067 | — |
| Valkyrie Clinical Trials | Los Angeles | California | 90067 | — |
| University of California Davis Comprehenvise Cancer Center | Sacramento | California | 95817 | — |
| University of California Davis Medical Center | Sacramento | California | 95817 | — |
| Providence Medical Foundation | Santa Rosa | California | 95403 | — |
| PCM Trails | Denver | Colorado | 80218 | — |
| PCM Trials | Denver | Colorado | 80218 | — |
| Smilow Cancer Hospital at Yale - New Haven | New Haven | Connecticut | 06510 | — |
| Yale-New Haven Hospital-Yale Cancer Center | New Haven | Connecticut | 06510 | — |
| Smilow Cancer Hospital Phase 1 Unit | New Haven | Connecticut | 06511 | — |
| Yale Cancer Center | New Haven | Connecticut | 06511 | — |
| Smilow Cancer Hospital Care Center at Trumbull | Trumbull | Connecticut | 06611 | — |
| Sylvester Comprehensive Cancer Center- The Lennar Foundation Medical Center | Coral Gables | Florida | 33146 | — |
| University of Miami Hospital and Clinics Deerfield Beach | Deerfield Beach | Florida | 33442 | — |
| Sylvester Comprehensive Cancer Center | Miami | Florida | 33136 | — |
| University of Miami Hospital and Clinics | Miami | Florida | 33136 | — |
| Sylvester Comprehensive Cancer Center - Kendall | Miami | Florida | 33176 | — |
| Sylvester Comprehensive Cancer Center Plantation | Plantation | Florida | 33324 | — |
| Georgia Cancer Center at Augusta University | Augusta | Georgia | 30912 | — |
| Wellstar MCG Health Clinical Research Pharmacy | Augusta | Georgia | 30912 | — |
| Brigham and Women's Hospital (BWH) | Boston | Massachusetts | 02115 | — |
| Dana-Farber Cancer Institute (DFCI) | Boston | Massachusetts | 02215 | — |
| Dana-Farber Cancer Institute - Chestnut Hill | Newton | Massachusetts | 02459 | — |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Karmanos Cancer Institute Weisberg Cancer Treatment Center | Farmington Hills | Michigan | 48334 | — |
| Minnesota Oncology Hematology, P.A. | Burnsville | Minnesota | 55337 | — |
| Allina Health Cancer institute | Coon Rapids | Minnesota | 55433 | — |
| Minnesota Oncology Hematology, P.A. | Coon Rapids | Minnesota | 55433 | — |
| M Health Fairview Cancer Clinic-Edina | Edina | Minnesota | 55435 | — |
| Minnesota Oncology Hematology, P.A. | Edina | Minnesota | 55435 | — |
| Minnesota Oncology Hematology, P.A. | Fridley | Minnesota | 55432 | — |
| Minnesota Oncology Hematology, P.A. | Maple Grove | Minnesota | 55369 | — |
| M Health Fairview St. John's Hospital | Maplewood | Minnesota | 55109 | — |
| Minnesota Oncology Hematology, P.A. | Maplewood | Minnesota | 55109 | — |
| Allina Health Cancer Institute (Virginia Piper Cancer Institute) | Minneapolis | Minnesota | 55404 | — |
| Minnesota Oncology Hematology, P.A. | Minneapolis | Minnesota | 55404 | — |
| Hennepin County Medical Center | Minneapolis | Minnesota | 55415 | — |
| North Memorial Health Cancer Center | Robbinsdale | Minnesota | 55422 | — |
| Park Nicollet Frauenshuh Cancer Center | Saint Louis Park | Minnesota | 55426 | — |
| Regulatory location : MMCORC | Saint Louis Park | Minnesota | 55426 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| Allina Health Cancer Institute-United(VPCI) | Saint Paul | Minnesota | 55102 | — |
| Minnesota Oncology Hematology, P.A. Cornerstone Medical Specialty Center | Woodbury | Minnesota | 55125 | — |
| Optimum Clinical Research Group, LLC | Albuquerque | New Mexico | 87109 | — |
| Southwest Women's Oncology Inc | Albuquerque | New Mexico | 87109 | — |
| NYU Langone Hospital - Long Island | Mineola | New York | 11501 | — |
| NYU Langone Hospital-Long Island | Mineola | New York | 11501 | — |
| Perlmutter Cancer Center at NYU Langone Hospital - Long Island | Mineola | New York | 11501 | — |
| Laura & Isaac Perlmutter Cancer Center at NYU Langone Health | New York | New York | 10016 | — |
| Laura & Isaac Perlmutter Cancer Center At NYU Langone | New York | New York | 10016 | — |
| Laura & Issac Perlmutter Cancer Center-NYU Ambulatory Care Center(ACC) | New York | New York | 10016 | — |
| NYU Langone Hospitals, NYU Langone Rusk Ambulatory Surgical Pharmacy | New York | New York | 10016 | — |
| NYU Langone Hospitals | New York | New York | 10016 | — |
| NYU Langone Medical Center (Tisch Hospital) | New York | New York | 10016 | — |
| Duke University Medical Center, Investigational Chemotherapy Services | Durham | North Carolina | 27710 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Providence Cancer Institute Franz Clinic | Portland | Oregon | 97213 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| Providence Oncology and Hematology Care Clinic - Westside | Portland | Oregon | 97225 | — |
| Providence St. Vincent Medical Center- Investigational Drug Services | Portland | Oregon | 97225 | — |
| Providence St. Vincent Medical Center | Portland | Oregon | 97225 | — |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Pacific Gynecology Specialists | Seattle | Washington | 98104 | — |
| Swedish Cancer Institute | Seattle | Washington | 98104 | — |
| Swedish First Hill IDS Pharmacy | Seattle | Washington | 98104 | — |
| Fred Hutchinson Cancer Center | Seattle | Washington | 98109 | — |
| Swedish Medical Center | Seattle | Washington | 98122 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 21 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06003231, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 22, 2026 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06003231 live on ClinicalTrials.gov.