Study of Obicetrapib & Ezetimibe Fixed Dose Combination on Top of Maximum Tolerated Lipid-Modifying Therapies
Public ClinicalTrials.gov record NCT06005597. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Placebo-Controlled, Double-Blind, Randomized, Phase 3 Study to Evaluate the Effect of Obicetrapib 10 mg and Ezetimibe 10 mg Fixed Dose Combination Daily on Top of Maximally Tolerated Lipid-Modifying Therapy in Participants With Heterozygous Familial Hypercholesterolemia (HeFH) and/or Atherosclerotic Cardiovascular Disease (ASCVD) or Multiple ASCVD Risk Factors
Study identification
- NCT ID
- NCT06005597
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- NewAmsterdam Pharma
- Industry
- Enrollment
- 407 participants
Conditions and interventions
Interventions
- Combination Therapy Combination Product
- Combination Therapy placebo Other
- Ezetimibe Placebo Other
- Monotherapy ezetimibe Drug
- Monotherapy obicetrapib Drug
- Obicetrapib Placebo Other
Combination Product · Other · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 29, 2024
- Primary completion
- Sep 24, 2024
- Completion
- Oct 15, 2024
- Last update posted
- Oct 7, 2025
2024
United States locations
- U.S. sites
- 45
- U.S. states
- 19
- U.S. cities
- 40
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| East Valley Diabetes & Endocrinology | Gilbert | Arizona | 85297 | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| Centricity Research - Columbus | Columbus | Georgia | 31904 | — |
| Center for Advanced Research and Education | Gainesville | Georgia | 30501 | — |
| NSC Research | Johns Creek | Georgia | 30024 | — |
| North Georgia Clinical Research | Woodstock | Georgia | 30189 | — |
| Evanston Premier Healthcare Research LLC | Skokie | Illinois | 60077 | — |
| Cardiovascular Research of Northwest Indiana, LLC | Munster | Indiana | 46321 | — |
| Grace Research, LLC - Bossier City, LA | Bossier City | Louisiana | 71111 | — |
| Horizon Research Group of Opelousas | Eunice | Louisiana | 70535 | — |
| Maryland Cardiovascular Specialists | Baltimore | Maryland | 21229 | — |
| TidalHealth Peninsula Regional, Inc. | Salisbury | Maryland | 21804 | — |
| McClaren Bay Heart and Vascular | Bay City | Michigan | 49770 | — |
| Northern Pines Health Center | Buckley | Michigan | 49620 | — |
| Sparrow Clinical Research Institute | Lansing | Michigan | 48912 | — |
| Oakland Medical Research Center | Troy | Michigan | 48085 | — |
| CentraCare Heart & Vascular Center | Saint Cloud | Minnesota | 56303 | — |
| North Mississippi Medical Center | Tupelo | Mississippi | 38801 | — |
| St. Louis Heart and Vascular Cardiology | St Louis | Missouri | 63136 | — |
| Washington University School of Medicine | St Louis | Missouri | 63136 | — |
| Triad Internal Medicine | Asheboro | North Carolina | 27203 | — |
| Cary Research Group, LLC | Cary | North Carolina | 27518 | — |
| Novant Health Clinical Research, LLC | Charlotte | North Carolina | 27701 | — |
| Novant Health Heart and Vascular Institute | Charlotte | North Carolina | 28204 | — |
| Lucas Research, Inc | Morehead City | North Carolina | 28557 | — |
| Wilmington Health Associates | Wilmington | North Carolina | 28412 | — |
| Metabolic and Atherosclerosis Research Center | Cincinnati | Ohio | 45227 | — |
| Summit Research Group, LLC | Stow | Ohio | 44240 | — |
| Capital Area Research | Camp Hill | Pennsylvania | 17074 | — |
| Monument Health Clinical Research, a department of Monument Health Rapid City Hospital, Inc | Rapid City | South Dakota | 57701 | — |
| Chattanooga Research & Medicine, PLLC | Chattanooga | Tennessee | 37404 | — |
| Cardiovascular Research of Knoxville | Powell | Tennessee | 37849 | — |
| PharmaTex Research, LLC | Amarillo | Texas | 79109 | — |
| Amarillo Heart Clinical Research Institute, Inc | Amarillo | Texas | 79124 | — |
| South Texas Clinical Research | Corpus Christi | Texas | 78404 | — |
| Diabetes and Thyroid Center of Fort Worth | Fort Worth | Texas | 76132 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Juno Research, LLC - Medical Center Office | Houston | Texas | 77054 | — |
| DM Clinical Research | Houston | Texas | 77375 | — |
| Wellness Clinical Research Associates | McKinney | Texas | 75069 | — |
| Northwest Houston Heart Center | Tomball | Texas | 77375 | — |
| Alpine Research Organization, Inc. | Clinton | Utah | 84015 | — |
| Spectrum Medical, Inc. | Danville | Virginia | 24541 | — |
| Hampton Roads Center for Clinical Research | Suffolk | Virginia | 23435 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06005597, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 7, 2025 · Synced May 6, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06005597 live on ClinicalTrials.gov.