BLOCK-SAH - PPF-Block for Post-SAH Headache

ClinicalTrials.gov ID: NCT06008795

Public ClinicalTrials.gov record NCT06008795. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 6, 2026, 9:51 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Pterygopalatine Fossa (PPF) Block as an Opioid Sparing Treatment for Acute Headache in Spontaneous Subarachnoid Hemorrhage

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

BLOCK-SAH is a phase II, multicenter, randomized, double-blinded, placebo-controlled clinical trial with a sequential parallel comparison design (SPCD) of bilateral pterygopalatine fossa (PPF) injections with 20mg ropivacaine + 4mg dexamethasone (active, PPF-block) compared to saline (placebo) for headache in survivors of aneurysmal subarachnoid hemorrhage (SAH), while monitoring intracranial arterial mean flow velocities with transcranial Doppler (TCD) peri-intervention (intervention = PPF-injections: active or placebo)

Study identification

NCT ID: NCT06008795
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: University of Florida; Other
Enrollment: 195 participants

Conditions and interventions

Conditions

Interventions

Drug · Procedure

Eligibility (public fields only)

Age range: 18 Years to 85 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 16, 2023
Primary completion: Jan 14, 2027
Completion: Feb 27, 2027
Last update posted: Jul 5, 2026

2023 – 2027

United States locations

U.S. sites: 13
U.S. states: 11
U.S. cities: 13

Facility	City	State	ZIP	Site status
University of Florida	Gainesville	Florida	32610	Recruiting
University of Miami	Miami	Florida	33136	Recruiting
Cleveland Clinic Foundation Martin Health	Stuart	Florida	34994	Recruiting
Emory University	Atlanta	Georgia	30322	Recruiting
University of Maryland Baltimore	Baltimore	Maryland	21201	Recruiting
Creighton University Medical Center	Omaha	Nebraska	68124	Recruiting
University of Rochester Medical College	Rochester	New York	14642	Recruiting
University of North Carolina	Chapel Hill	North Carolina	27599	Recruiting
University of Cincinnati	Cincinnati	Ohio	45267	Recruiting
Oregon Health and Sciences University	Portland	Oregon	97239	Recruiting
Thomas Jefferson University	Philadelphia	Pennsylvania	19107	Not yet recruiting
University of Washington	Seattle	Washington	98104	Recruiting
Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06008795, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jul 5, 2026 · Synced Sep 6, 2026

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The complete protocol, eligibility criteria, and contact information for NCT06008795 live on ClinicalTrials.gov.

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