First-In-Human Study of STX-721/PFL-721 in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring EGFR or HER2 Exon 20 Insertion Mutations

ClinicalTrials.gov ID: NCT06043817

Public ClinicalTrials.gov record NCT06043817. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search

ClinicalTrials.gov public records Last synced Apr 27, 2026, 7:25 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Study identification

NCT ID: NCT06043817
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: Pierre Fabre Medicament; Industry
Enrollment: 251 participants

Conditions and interventions

Conditions

Interventions

STX-721/PFL-721 (3 dose levels) Drug
STX-721/PFL-721 (Escalated) Drug
STX-721/PFL-721 (RP2D) Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Sep 25, 2023
Primary completion: Nov 30, 2029
Completion: Nov 30, 2029
Last update posted: Apr 23, 2026

2023 – 2029

United States locations

U.S. sites: 9
U.S. states: 7
U.S. cities: 9

Facility	City	State	ZIP	Site status
City of Hope	Duarte	California	91010	Recruiting
City of Hope	Huntington Beach	California	92648	Recruiting
City of Hope	Irvine	California	92618	Recruiting
Levine Cancer Institute - Charlotte	Charlotte	North Carolina	28204-2990	Recruiting
Thomas Jefferson University Research Facility	Philadelphia	Pennsylvania	19107	Recruiting
SCRI Oncology Partners - PPDS	Nashville	Tennessee	37203	Recruiting
University of Texas MD Anderson Cancer Center	Houston	Texas	77030-4009	Recruiting
University of Utah - Huntsman Cancer Institute - PPDS	Salt Lake City	Utah	84112-5550	Recruiting
NEXT Virginia	Fairfax	Virginia	22031-2171	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 15 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06043817, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 23, 2026 · Synced Apr 27, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06043817 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →