A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression

ClinicalTrials.gov ID: NCT06051695

Public ClinicalTrials.gov record NCT06051695. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 24, 2026, 6:38 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Seamless Phase 1/2 Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Autologous Logic-gated Tmod™ CAR T Products, in Heterozygous HLA-A*02 Adults With Recurrent Unresectable, Locally Advanced, or Metastatic Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression

Study identification

NCT ID: NCT06051695
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: A2 Biotherapeutics Inc.; Industry
Enrollment: 474 participants

Conditions and interventions

Conditions

Interventions

A2B543 Biological
A2B694 Biological
xT CDx with HLA-LOH Assay Diagnostic Test

Biological · Diagnostic Test

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Apr 2, 2024
Primary completion: May 31, 2028
Completion: May 31, 2029
Last update posted: Feb 19, 2026

2024 – 2029

United States locations

U.S. sites: 12
U.S. states: 9
U.S. cities: 12

Facility	City	State	ZIP	Site status
Banner Health	Gilbert	Arizona	85234	Recruiting
UCSD Moores Cancer Center	La Jolla	California	92093	Recruiting
UCLA Medical Center	Los Angeles	California	90404	Recruiting
Stanford University	Stanford	California	94305	Recruiting
Mayo Clinic	Jacksonville	Florida	32224	Recruiting
Moffitt Cancer Center	Tampa	Florida	33606	Recruiting
Mayo Clinic Rochester	Rochester	Minnesota	55905	Recruiting
Washington University	St Louis	Missouri	63110	Recruiting
NYU Langone Medical Center	New York	New York	10016	Recruiting
The Ohio State University Comprehensive Cancer Center	Columbus	Ohio	43210	Recruiting
Vanderbilt University Medical Center	Nashville	Tennessee	37232	Recruiting
Fred Hutchinson Cancer Center	Seattle	Washington	98109	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06051695, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Feb 19, 2026 · Synced Apr 24, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06051695 live on ClinicalTrials.gov.

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