AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy

ClinicalTrials.gov ID: NCT06063850

Public ClinicalTrials.gov record NCT06063850. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 20, 2026, 2:14 AM EDT

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Official title

A Multi-center, Phase 1/2a, First-in-human (FIH) Study Investigating the Safety, Tolerability, and Efficacy of AMT-260 in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy (MTLE) Administered Via Magnetic Resonance Imaging (MRI)-Guided Convection-enhanced Delivery (CED)

Study identification

NCT ID: NCT06063850
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: UniQure Biopharma B.V.; Industry
Enrollment: 12 participants

Conditions and interventions

Conditions

Mesial Temporal Lobe Epilepsy

Interventions

AAV9-hSyn1-miGRIK2 Genetic

Genetic

Eligibility (public fields only)

Age range: 18 Years to 75 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 11, 2024
Primary completion: Nov 29, 2026
Completion: Nov 30, 2031
Last update posted: Apr 5, 2026

2024 – 2031

United States locations

U.S. sites: 18
U.S. states: 14
U.S. cities: 18

Facility	City	State	ZIP	Site status
University of Alabama at Birmingham	Birmingham	Alabama	35294-0021	Recruiting
Mayo Clinic Arizona	Phoenix	Arizona	85054	Recruiting
Stanford University	Palo Alto	California	94304	Recruiting
Mayo Clinic Florida	Jacksonville	Florida	32224	Recruiting
Kansas University Medical Center	Kansas City	Kansas	66160	Recruiting
Johns Hopkins School of Medicine	Baltimore	Maryland	21287	Recruiting
Midatlantic Epilepsy and Sleep Center	Bethesda	Maryland	20817	Recruiting
Massachusetts General Hospital	Boston	Massachusetts	02114	Recruiting
Corewell Health	Grand Rapids	Michigan	49503	Recruiting
Dartmouth Hitchcock Medical Center	Lebanon	New Hampshire	03756	Recruiting
Northeast Regional Epilepsy Group	Hackensack	New Jersey	07601	Recruiting
Robert Wood Johnson Hospital	New Brunswick	New Jersey	08901	Recruiting
Cleveland Clinic	Cleveland	Ohio	44195	Recruiting
Ohio State University	Columbus	Ohio	43210	Recruiting
Hospital of the University of Pennsylvania	Philadelphia	Pennsylvania	19104	Recruiting
Allegheny Health Network	Pittsburgh	Pennsylvania	15212	Recruiting
Baylor Scott & White Medical Center	Austin	Texas	78735	Recruiting
Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06063850, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 5, 2026 · Synced May 20, 2026

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The complete protocol, eligibility criteria, and contact information for NCT06063850 live on ClinicalTrials.gov.

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