Cytomegalovirus (CMV) Vaccine in Orthotopic Liver Transplant Candidates
Public ClinicalTrials.gov record NCT06075745. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Cytomegalovirus (CMV) Vaccine in Orthotopic Liver Transplant Candidates (CTOT-44)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a multi-center clinical trial in Cytomegalovirus (CMV) seronegative prospective liver transplant recipients to determine the efficacy of two doses of Cytomegalovirus-Modified Vaccinia Ankara (CMV-MVA) Triplex CMV vaccine pre-transplant. The primary objective is to assess the effect of pre-transplant (Tx) Triplex vaccination on duration of CMV antiviral therapy (AVT) within the first 100 days post-Tx in CMV seropositive donor (D+) and seronegative (R-) (D+R-) liver transplant recipients (LTxRs). A protocol-mandated preemptive therapy (PET) will be used for CMV disease prevention in D+R- LTxRs.
Study identification
- NCT ID
- NCT06075745
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 416 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 4, 2024
- Primary completion
- Jun 29, 2027
- Completion
- Feb 27, 2028
- Last update posted
- Jul 23, 2026
2024 – 2028
United States locations
- U.S. sites
- 18
- U.S. states
- 15
- U.S. cities
- 18
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham, School of Medicine | Birmingham | Alabama | 35233 | Withdrawn |
| University of California, San Diego School of Medicine | La Jolla | California | 92093 | Recruiting |
| Stanford University | Redwood City | California | 94063-3126 | Recruiting |
| University of California, San Francisco | San Francisco | California | 94143-0000 | Recruiting |
| University of Miami, Jackson Memorial Hospital | Miami | Florida | 33136-1003 | Recruiting |
| Emory University Hospital | Atlanta | Georgia | 30322-0000 | Recruiting |
| Northwestern University, Feinberg School of Medicine | Chicago | Illinois | 60611-0000 | Recruiting |
| Johns Hopkins University School of Medicine | Baltimore | Maryland | 21205-0000 | Recruiting |
| University of Michigan Medical Center | Ann Arbor | Michigan | 48109-1274 | Recruiting |
| Mayo Clinic, Rochester - College of Medicine and Science | Rochester | Minnesota | 55905-0001 | Recruiting |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198-7835 | Recruiting |
| Duke University School of Medicine | Durham | North Carolina | 27710-1000 | Recruiting |
| Oregon Health & Sciences University | Portland | Oregon | 97239-3098 | Recruiting |
| University of Pennsylvania School of Medicine | Philadelphia | Pennsylvania | 19104-5127 | Recruiting |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15213-0000 | Recruiting |
| Vanderbilt University School of Medicine | Nashville | Tennessee | 37232-0011 | Recruiting |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390-0000 | Recruiting |
| University of Washington Medical Center: Transplantation | Seattle | Washington | 98195 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06075745, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 23, 2026 · Synced Sep 7, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06075745 live on ClinicalTrials.gov.