ClinicalTrials.gov record
Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic nHCM
ClinicalTrials.gov ID: NCT06081894
Public ClinicalTrials.gov record NCT06081894. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 10, 2026, 1:33 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multi-Center, Randomized, Double-Blind Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy
Study identification
- NCT ID
- NCT06081894
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Cytokinetics
- Industry
- Enrollment
- 500 participants
Conditions and interventions
Interventions
- Aficamten Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 29, 2023
- Primary completion
- May 31, 2026
- Completion
- Aug 31, 2026
- Last update posted
- Feb 1, 2026
2023 – 2026
United States locations
- U.S. sites
- 60
- U.S. states
- 30
- U.S. cities
- 49
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35233 | — |
| UC San Diego Health - Sulpizio Cardiovascular Center | La Jolla | California | 92037 | — |
| Keck Medical Center of USC (Outpatient Clinic) | Los Angeles | California | 90033 | — |
| Cedars-Sinai Medical Center (Smidt Heart Institute) | Los Angeles | California | 90048 | — |
| UCLA Medical Center Cardiovascular Clinic | Los Angeles | California | 90095 | — |
| University of California San Francisco | San Francisco | California | 94143 | — |
| Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Torrance | California | 90502 | — |
| Yale New Haven Hospital | New Haven | Connecticut | 06519 | — |
| MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| Holy Cross Medical Group - Cardiology Associates | Fort Lauderdale | Florida | 33308 | — |
| Investigational Drug Services, AdventHealth Orlando | Orlando | Florida | 32804 | — |
| Emory Clinic | Atlanta | Georgia | 30322 | — |
| Piedmont Heart Institute (CPET) | Fayetteville | Georgia | 30214 | — |
| The Queen's Medical Center-Punchbowl | Honolulu | Hawaii | 96813 | — |
| Northwestern University | Evanston | Illinois | 60208 | — |
| Ascension St. Vincent | Indianapolis | Indiana | 46260 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| The University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| MedStar Union Memorial Hospital | Baltimore | Maryland | 21218 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Lahey Hospital & Medical Center | Burlington | Massachusetts | 01803 | — |
| Michigan Medicine | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| M Health Fairview University of Minnesota Medical Center - East Bank | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Saint Luke's Hospital of Kansas City | Kansas City | Missouri | 64111 | — |
| Morristown Medical Center | Morristown | New Jersey | 07960 | — |
| Northwell Health North Shore University Hospital | Manhasset | New York | 11030 | — |
| NYU Langone Health | New York | New York | 10016 | — |
| Weill Cornell Medicine | New York | New York | 10021 | — |
| Mount Sinai Hospital | New York | New York | 10029 | — |
| Columbia University Medical Center/New York Presbyterian Hospital | New York | New York | 10032 | — |
| Westchester Medical Center | Valhalla | New York | 10595 | — |
| Sanger Heart & Vascular Institute - HCM Clinic | Charlotte | North Carolina | 28204 | — |
| The Lindner Research Center at The Christ Hospital | Cincinnati | Ohio | 45219 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Providence St. Vincent Medical Center | Portland | Oregon | 97225 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| Hospital of the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| UPMC Presbyterian | Pittsburgh | Pennsylvania | 15213 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Greenville Memorial Hospital | Greenville | South Carolina | 29605-5601 | — |
| Ascension Saint Thomas Heart West | Nashville | Tennessee | 37205 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| University of Utah Health | Salt Lake City | Utah | 84132 | — |
| University of Virginia | Charlottesville | Virginia | 22903 | — |
| Inova Health Care Services | Falls Church | Virginia | 22042 | — |
| VCU Health Downtown Medical Campus | Richmond | Virginia | 23298 | — |
| Carilion Clinic Cardiology | Roanoke | Virginia | 24014 | — |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | — |
| Providence Sacred Heart Medical Center & Children's Hospital (CPET) | Spokane | Washington | 99204 | — |
| WVU Medicine | Morgantown | West Virginia | 26506 | — |
| University of Wisconsin Hospitals and Clinics | Madison | Wisconsin | 53792 | — |
| Aurora St. Luke's Medical Center | Milwaukee | Wisconsin | 53215 | — |
| Medical College of Wisconsin/Froedtert Hospital | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 120 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06081894, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 1, 2026 · Synced May 10, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06081894 live on ClinicalTrials.gov.