Pulsed Field Ablation (PFA) vs Anti-Arrhythmic Drug (AAD) Therapy as a First Line Treatment for Persistent Atrial Fibrillation
Public ClinicalTrials.gov record NCT06096337. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Prospective Randomized Multicenter Global Study Comparing Pulsed Field Ablation (PFA) Versus Anti-Arrhythmic Drug (AAD) Therapy as a First Line Treatment for Persistent Atrial Fibrillation
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to establish the safety and effectiveness of pulsed field ablation as a first-line ablation treatment for subjects with persistent atrial fibrillation as compared to subjects who received an initial treatment with anti-arrhythmic drugs.
Study identification
- NCT ID
- NCT06096337
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 484 participants
Conditions and interventions
Conditions
Interventions
- FARAPULSE™ Pulsed Field Ablation (PFA) System Device
- Anti-Arrhythmic Drug (AAD): Flecainide, Sotalol, Propafenone, Dofetilide, and Dronedarone Drug
Device · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 28, 2023 (Actual)
- Primary completion
- Feb 4, 2026 (Actual)
- Completion
- Feb 4, 2028 (Estimated)
- Last update posted
- Aug 28, 2026
2023 – 2028
United States locations
- U.S. sites
- 42
- U.S. states
- 26
- U.S. cities
- 41
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35249-7333 | — |
| Banner University Medical Center Phoenix | Phoenix | Arizona | 85006 | — |
| Phoenix Cardiovascular Research Group | Phoenix | Arizona | 85018 | — |
| Arrhythmia Research Group | Jonesboro | Arkansas | 72401 | — |
| Scripps Memorial Hosptial | La Jolla | California | 92037 | — |
| Stanford University Medical Center | Palo Alto | California | 94305-5406 | — |
| Cardiology Associates Medical Group, Inc | Ventura | California | 93003 | — |
| HCA Florida Mercy Hospital | Miami | Florida | 33133 | — |
| Sarasota Memorial Hospital | Sarasota | Florida | 34239 | — |
| Tallahassee Memorial Hospital | Tallahassee | Florida | 32308 | — |
| St. Joseph's Hospital | Tampa | Florida | 33614 | — |
| Emory University Hospital | Atlanta | Georgia | 30342 | — |
| Memorial Health University Medical Center | Savannah | Georgia | 31404 | — |
| St. John's Hospital | Springfield | Illinois | 62701 | — |
| Community Heart and Vascular Hospital | Indianapolis | Indiana | 46250 | — |
| Mercy Hospital Medical Center-Hospital | West Des Moines | Iowa | 50266 | — |
| Baptist Health Lexington | Lexington | Kentucky | 40503 | — |
| Johns Hopkins Hospital | Baltimore | Maryland | 21287 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Southcoast Physicians Group | Fall River | Massachusetts | 02720 | — |
| University of Michigan Hospitals | Ann Arbor | Michigan | 48108 | — |
| Corewell Health | Grand Rapids | Michigan | 49503 | — |
| Mayo Clinic Foundation-Hospital | Rochester | Minnesota | 55905 | — |
| Catholic Medical Center | Manchester | New Hampshire | 03102 | — |
| Valley Hospital | Paramus | New Jersey | 07652 | — |
| Northwell Health | Bay Shore | New York | 11706 | — |
| Kaleida Health | Buffalo | New York | 14203 | — |
| Weill Cornell Medical University | New York | New York | 10021 | — |
| Good Samaritan - Suffern | Suffern | New York | 10901 | — |
| Wake Forest University School of Medicine | Winston-Salem | North Carolina | 27157 | — |
| Bethesda North Hospital | Cincinnati | Ohio | 45242 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| OhioHealth Research and Innovation Institute - Riverside Methodist Hospital | Columbus | Ohio | 43214 | — |
| Oklahoma Heart Institute | Tulsa | Oklahoma | 74104 | — |
| York Hospital | York | Pennsylvania | 17403 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| University of Texas Medical Branch | Galveston | Texas | 77555-0737 | — |
| Orion Medical | Houston | Texas | 77034 | — |
| Christus Trinity Mother Frances Health System | Tyler | Texas | 75701 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| Chippenham & Johnston-Willis Hospital (CJW) | Richmond | Virginia | 23225 | — |
| Aurora St. Luke's Medical Center | Milwaukee | Wisconsin | 53215 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 19 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06096337, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 28, 2026 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06096337 live on ClinicalTrials.gov.