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Recruiting Phase 2 Interventional

Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib

ClinicalTrials.gov ID: NCT06120140

Public ClinicalTrials.gov record NCT06120140. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 5:08 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2, Open-Label, Randomized Trial Evaluating the Impact of Enhanced Versus Standard Dermatologic Management on Selected Dermatologic Adverse Events Among Patients With Locally Advanced or Metastatic EGFR-Mutated NSCLC Treated First-Line With Amivantamab + Lazertinib

Study identification

NCT ID
NCT06120140
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 2
Lead sponsor
Janssen Research & Development, LLC
Industry
Enrollment
300 participants

Conditions and interventions

Interventions

  • Amivantamab IV Drug
  • Amivantamab SC Drug
  • Chlorhexidine Drug
  • Clindamycin Drug
  • Clobetasol Drug
  • Doxycycline Drug
  • Lazertinib Drug
  • Minocycline Drug
  • Noncomedogenic skin moisturizer Other
  • Propranolol Drug
  • Ruxolitinib Other
  • Tacrolimus Other
  • Timolol Drug
  • Zinc gluconate Drug

Drug · Other

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Feb 15, 2024
Primary completion
May 30, 2027
Completion
Jan 30, 2032
Last update posted
Apr 12, 2026

2024 – 2032

United States locations

U.S. sites
28
U.S. states
13
U.S. cities
28
Facility City State ZIP Site status
Ironwood Cancer and Research Center Chandler Arizona 85224 Recruiting
City of Hope Duarte California 91010 Recruiting
Providence Fullerton Fullerton California 92835 Recruiting
Los Angeles Cancer Network Glendale California 91204 Recruiting
City of Hope Seacliff Huntington Beach California 92648 Recruiting
City of Hope Orange County Lennar Foundation Cancer Center Irvine California 92618 Recruiting
City of Hope Long Beach Elm Long Beach California 90813 Recruiting
Cancer and Blood Specialty Clinic Los Alamitos California 90720 Recruiting
Keck Hospital of USC Los Angeles California 90033 Recruiting
USC Norris Oncology Hematology Newport Beach Newport Beach California 92663 Recruiting
Kaiser Permanente Oakland Medical Center Oakland California 94611 Recruiting
Kaiser Permanente Roseville Medical Center Roseville California 95661 Recruiting
Kaiser Permanente San Francisco Medical Center San Francisco California 94115 Recruiting
Kaiser Permanente Santa Clara Medical Center Santa Clara California 95051 Recruiting
City of Hope South Pasadena South Pasadena California 91030 Recruiting
Kaiser Permanente Northern California Vallejo California 94589 Recruiting
Kaiser Permanente Walnut Creek Medical Center Walnut Creek California 94596 Recruiting
University Cancer & Blood Center Athens Georgia 30607 Recruiting
Hope and Healing Care Hinsdale Illinois 60521 Recruiting
Oncology Hematology Associates Springfield Missouri 65807 Recruiting
Renown Health Medical Oncology Reno Nevada 89502 Recruiting
Hunterdon Hematology Oncology Flemington New Jersey 08822 Completed
Clinical Research Alliance Inc Westbury New York 11590 Completed
Regional Medical Oncology Center Wilson North Carolina 27893 Recruiting
University Hospitals Cleveland Medical Center Cleveland Ohio 44106 Recruiting
Virginia Cancer Specialists Fairfax Virginia 22031 Recruiting
Valley Medical Center Renton Washington 98055 Completed
Gundersen Health System West Salem Wisconsin 54669 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 65 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06120140, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Apr 12, 2026 · Synced May 8, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06120140 live on ClinicalTrials.gov.

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