ClinicalTrials.gov record
A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-2)
ClinicalTrials.gov ID: NCT06126224
Public ClinicalTrials.gov record NCT06126224. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 8, 2026, 8:09 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Safety and Efficacy of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease
Study identification
- NCT ID
- NCT06126224
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Karuna Therapeutics, Inc., a Bristol Myers Squibb company
- Industry
- Enrollment
- 500 participants
Conditions and interventions
Interventions
- KarXT Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 55 Years to 90 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 27, 2023
- Primary completion
- Dec 8, 2026
- Completion
- Dec 8, 2026
- Last update posted
- Apr 29, 2026
2023 – 2026
United States locations
- U.S. sites
- 70
- U.S. states
- 13
- U.S. cities
- 46
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Local Institution - 1116 | Chandler | Arizona | 85286 | Active, not recruiting |
| Local Institution - 1044 | Phoenix | Arizona | 85012-2836 | Active, not recruiting |
| Local Institution - 1104 | Anaheim | California | 92805-5854 | Active, not recruiting |
| Local Institution - 1119 | Canoga Park | California | 91303-1844 | Active, not recruiting |
| Local Institution - 1151 | Encino | California | 91316 | Active, not recruiting |
| Local Institution - 1142 | Lancaster | California | 93534-2839 | Active, not recruiting |
| Local Institution - 1117 | Los Alamitos | California | 90720-6506 | Active, not recruiting |
| Local Institution - 1103 | Sherman Oaks | California | 91403-2131 | Active, not recruiting |
| Local Institution - 1007 | Walnut Creek | California | 94596 | Active, not recruiting |
| Local Institution - 1160 | Apopka | Florida | 32703-5835 | Withdrawn |
| Local Institution - 1156 | Clermont | Florida | 34711-5190 | Active, not recruiting |
| Local Institution - 1138 | Cutler Bay | Florida | 33189-1230 | Active, not recruiting |
| Local Institution - 1162 | Delray Beach | Florida | 33445-2581 | Active, not recruiting |
| Local Institution - 1164 | Doral | Florida | 33122-1620 | Active, not recruiting |
| Local Institution - 1165 | Fort Myers | Florida | 33912-4302 | Active, not recruiting |
| Local Institution - 1155 | Hialeah | Florida | 33012-3158 | Active, not recruiting |
| Local Institution - 1107 | Hialeah | Florida | 33012-3618 | Active, not recruiting |
| Local Institution - 1120 | Hialeah | Florida | 33012-4648 | Active, not recruiting |
| Local Institution - 1140 | Hialeah | Florida | 33016-1814 | Active, not recruiting |
| Local Institution - 0150 | Homestead | Florida | 33032-8187 | Active, not recruiting |
| Local Institution - 1145 | Homestead | Florida | 33032-8187 | Active, not recruiting |
| Local Institution - 1127 | Largo | Florida | 33777-1359 | Active, not recruiting |
| Local Institution - 1039 | Maitland | Florida | 32751-5669 | Active, not recruiting |
| Local Institution - 1146 | Maitland | Florida | 32751-6138 | Active, not recruiting |
| Local Institution - 1159 | Miami | Florida | 33032 | Active, not recruiting |
| Local Institution - 1118 | Miami | Florida | 33122-1721 | Active, not recruiting |
| Local Institution - 1111 | Miami | Florida | 33126-5683 | Active, not recruiting |
| Local Institution - 1108 | Miami | Florida | 33133-4231 | Active, not recruiting |
| Local Institution - 1125 | Miami | Florida | 33135-1601 | Active, not recruiting |
| Local Institution - 1115 | Miami | Florida | 33135 | Active, not recruiting |
| Local Institution - 1143 | Miami | Florida | 33145-2455 | Active, not recruiting |
| Local Institution - 1113 | Miami | Florida | 33155-6630 | Active, not recruiting |
| Local Institution - 1009 | Miami | Florida | 33155 | Active, not recruiting |
| Local Institution - 1129 | Miami | Florida | 33165-3947 | Active, not recruiting |
| Local Institution - 1150 | Miami | Florida | 33165 | Active, not recruiting |
| Local Institution - 1109 | Miami | Florida | 33174-2950 | Active, not recruiting |
| Local Institution - 1158 | Miami | Florida | 33175 | Active, not recruiting |
| Local Institution - 1147 | Miami | Florida | 33176-7947 | Active, not recruiting |
| Local Institution - 1105 | Miami | Florida | 33179-2537 | Active, not recruiting |
| Local Institution - 1157 | Miami | Florida | 33184-1412 | Active, not recruiting |
| Local Institution - 1126 | Miami Gardens | Florida | 33056-4000 | Active, not recruiting |
| Local Institution - 1102 | Miami Lakes | Florida | 33014-6435 | Active, not recruiting |
| Local Institution - 1136 | Orlando | Florida | 32806-1041 | Active, not recruiting |
| Local Institution - 1112 | Orlando | Florida | 32807-3555 | Active, not recruiting |
| Local Institution - 1137 | Port Orange | Florida | 32127-2914 | Active, not recruiting |
| Health Synergy Clinical Research,LLC - Stuart | Stuart | Florida | 34994 | Recruiting |
| Local Institution - 1133 | Sweetwater | Florida | 33182 | Active, not recruiting |
| Local Institution - 1041 | Tampa | Florida | 33607-4629 | Active, not recruiting |
| Local Institution - 1124 | Tampa | Florida | 33614-2700 | Active, not recruiting |
| Local Institution - 1123 | Tampa | Florida | 33614-2846 | Completed |
| Local Institution - 1110 | Tampa | Florida | 33629-5837 | Active, not recruiting |
| Local Institution - 1040 | The Villages | Florida | 32159-8986 | Withdrawn |
| Local Institution - 1131 | Viera | Florida | 32940 | Recruiting |
| Local Institution - 1152 | Augusta | Georgia | 30912-0020 | Withdrawn |
| Local Institution - 1141 | Columbus | Georgia | 31909-1693 | Withdrawn |
| Local Institution - 1161 | Decatur | Georgia | 30030 | Active, not recruiting |
| Local Institution - 1148 | Elgin | Illinois | 60123-9215 | Active, not recruiting |
| Local Institution - 1114 | Marrero | Louisiana | 70072-3083 | Active, not recruiting |
| Local Institution - 1139 | Rochester Hills | Michigan | 48307-2760 | Active, not recruiting |
| Local Institution - 1132 | Flowood | Mississippi | 39232 | Active, not recruiting |
| Local Institution - 1144 | Las Vegas | Nevada | 89106-4145 | Withdrawn |
| Local Institution - 1153 | New Hyde Park | New York | 11042-2062 | Withdrawn |
| Local Institution - 1135 | Port Jefferson Station | New York | 11776-3386 | Withdrawn |
| Local Institution - 1122 | Dayton | Ohio | 45459-4248 | Active, not recruiting |
| Local Institution - 1149 | Malvern | Pennsylvania | 19355-3267 | Withdrawn |
| Local Institution - 1106 | Cypress | Texas | 77429-6070 | Recruiting |
| Local Institution - 1163 | Houston | Texas | 77074-2085 | Active, not recruiting |
| Local Institution - 1154 | Katy | Texas | 77450-1759 | Active, not recruiting |
| Local Institution - 1121 | Red Oak | Texas | 75154 | Withdrawn |
| Local Institution - 1134 | Stafford | Texas | 77477-3929 | Active, not recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 84 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06126224, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 29, 2026 · Synced May 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06126224 live on ClinicalTrials.gov.