A Study to Learn About the Study Medicine Called PF-07868489 in Healthy Adult People and in People With Pulmonary Arterial Hypertension
Public ClinicalTrials.gov record NCT06137742. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 1 / 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF SINGLE ESCALATING DOSES OF PF-07868489 IN HEALTHY ADULT PARTICIPANTS AND, ADDITIONALLY, CLINICAL ACTIVITY OF REPEAT DOSES IN PARTICIPANTS WITH PULMONARY ARTERIAL HYPERTENSION
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of the study is to learn how the study medicine called PF-07868489 is tolerated and acts in healthy adult people and people with pulmonary arterial hypertension (PAH). Part A: An investigator- and participant-blind, sponsor-open, placebo-controlled, single ascending dose study to assess the safety, tolerability, and pharmacokinetics (PK) of PF-07868489 in healthy adult participants. Part B: A 24-week, randomized, double blind, placebo-controlled study to assess the safety, tolerability, PK, and pharmacodynamics (PD) of PF-07868489 in adult participants with PAH.
Study identification
- NCT ID
- NCT06137742
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 97 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 17, 2023 (Actual)
- Primary completion
- Jul 31, 2026 (Actual)
- Completion
- Jul 31, 2026 (Actual)
- Last update posted
- Aug 21, 2026
2023 – 2026
United States locations
- U.S. sites
- 16
- U.S. states
- 4
- U.S. cities
- 8
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Anaheim Clinical Trials, LLC | Anaheim | California | 92801 | — |
| UCI Health - Costa Mesa | Costa Mesa | California | 92627 | — |
| UCI Health Center for Innovative Health Therapies (CIHT) | Orange | California | 92868 | — |
| University of California, Irvine Medical Center | Orange | California | 92868 | — |
| UCSF Health St. Mary's Hospital | San Francisco | California | 94117 | — |
| UCSF Helen Diller Medical Center at Parnassus Heights | San Francisco | California | 94143 | — |
| Icahn school of medicine at Mount Sinai | New York | New York | 10029 | — |
| Mount Sinai Hospital | New York | New York | 10029 | — |
| Eastowne 100 Medical Office Building | Chapel Hill | North Carolina | 27514 | — |
| Eastowne Medical Office Building - Clinical Research Unit | Chapel Hill | North Carolina | 27514 | — |
| UNC Health - Eastowne Medical Office | Chapel Hill | North Carolina | 27514 | — |
| UNC Hospitals | Chapel Hill | North Carolina | 27514 | — |
| Investigational Drug Services Pharmacy | Morrisville | North Carolina | 27560 | — |
| Medical University of South Carolina - Nexus | Charleston | South Carolina | 29425 | — |
| Medical University of South Carolina - Radiology | Charleston | South Carolina | 29425 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 30 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06137742, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 21, 2026 · Synced Oct 18, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06137742 live on ClinicalTrials.gov.