A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight
Public ClinicalTrials.gov record NCT06143956. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Master Protocol for a Randomized, Controlled, Clinical Trial of Multiple Interventions for Chronic Weight Management in Adult Participants With Obesity or Overweight
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this Phase-2 chronic weight management master protocol (CWMM) is to create a framework to evaluate the safety and efficacy of various investigational interventions for chronic weight management with intervention-specific appendices (ISAs). The CWMM establishes entry criteria for newly enrolled participants across the master and the ISAs. The ISAs may start independently of other ISAs as interventions become available for clinical testing. The results for the CWMM screening record will be reported when all the ISA's complete.
Study identification
- NCT ID
- NCT06143956
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 1,481 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 16, 2023
- Primary completion
- Aug 31, 2027
- Completion
- Jan 31, 2028
- Last update posted
- Aug 5, 2026
2023 – 2028
United States locations
- U.S. sites
- 49
- U.S. states
- 22
- U.S. cities
- 47
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| The Institute for Liver Health II dba Arizona Clinical Trials - Mesa | Chandler | Arizona | 85225 | Recruiting |
| HOPE Research Institute | Phoenix | Arizona | 85032 | Completed |
| Headlands Research - Scottsdale | Scottsdale | Arizona | 85260 | Recruiting |
| The Institute for Liver Health II dba Arizona Liver Health-Tucson | Tucson | Arizona | 85712 | Recruiting |
| NorCal Medical Research, Inc | Greenbrae | California | 94904 | Recruiting |
| Velocity Clinical Research, Huntington Park | Huntington Park | California | 90255 | Recruiting |
| Peninsula Research Associates | Rolling Hills Estates | California | 90274 | Recruiting |
| Diablo Clinical Research, Inc. | Walnut Creek | California | 94598 | Recruiting |
| Stamford Therapeutics Consortium | Stamford | Connecticut | 06905 | Recruiting |
| Northeast Research Institute (NERI) | Fleming Island | Florida | 32003 | Completed |
| New Horizon Research Center | Miami | Florida | 33165 | Recruiting |
| Indago Research & Health Center, Inc | Miami Lakes | Florida | 33016 | Recruiting |
| Suncoast Clinical Research, Inc. | New Port Richey | Florida | 34652 | Recruiting |
| Charter Research - Winter Park | Orlando | Florida | 32803 | Recruiting |
| Charter Research - Lady Lake | The Villages | Florida | 32162 | Recruiting |
| Pacific Diabetes & Endocrine Center | Honolulu | Hawaii | 96817 | Completed |
| Medical Research Partners | Ammon | Idaho | 83406 | Recruiting |
| Great Lakes Clinical Trials - Ravenswood | Chicago | Illinois | 60640 | Recruiting |
| NorthShore University Health System | Skokie | Illinois | 60077 | Active, not recruiting |
| Iowa Diabetes and Endocrinology Research Center | West Des Moines | Iowa | 50266 | Recruiting |
| Cotton O'Neil Diabetes & Endocrinology | Topeka | Kansas | 66606 | Recruiting |
| Monroe Biomedical Research - Louisville | Louisville | Kentucky | 40213 | Recruiting |
| Knownwell | Needham | Massachusetts | 02492 | Recruiting |
| Lucida Clinical Trials | New Bedford | Massachusetts | 02740 | Recruiting |
| Headlands Research - Detroit | Southfield | Michigan | 48034 | Recruiting |
| Arcturus Healthcare , PLC, Troy Internal Medicine Research Division | Troy | Michigan | 48098 | Recruiting |
| StudyMetrix Research | City of Saint Peters | Missouri | 63303 | Recruiting |
| Clinvest Headlands Llc | Springfield | Missouri | 65807 | Recruiting |
| Las Vegas Medical Research | Las Vegas | Nevada | 89128 | Recruiting |
| Dent Neurologic Institute | Amherst | New York | 14226 | Recruiting |
| Velocity Clinical Research, Syracuse | East Syracuse | New York | 13057 | Recruiting |
| North Suffolk Neurology | Port Jefferson Station | New York | 11776 | Completed |
| Rochester Clinical Research, LLC | Rochester | New York | 14609 | Recruiting |
| Medication Management | Greensboro | North Carolina | 27405 | Recruiting |
| Monroe Biomedical Research | Monroe | North Carolina | 28112 | Recruiting |
| Lucas Research, Inc | Morehead City | North Carolina | 28557 | Recruiting |
| Lucas Research, Inc. | New Bern | North Carolina | 28562 | Recruiting |
| CTI Clinical Research Center | Cincinnati | Ohio | 45212 | Recruiting |
| Tribe Clinical Research, LLC | Greenville | South Carolina | 29607 | Recruiting |
| Quality Medical Research | Nashville | Tennessee | 37211 | Recruiting |
| IMA Clinical Research Austin | Austin | Texas | 78745 | Recruiting |
| Velocity Clinical Research, Dallas | Dallas | Texas | 75230 | Recruiting |
| FutureSearch Trials of Dallas | Dallas | Texas | 75251 | Recruiting |
| PlanIt Research, PLLC | Houston | Texas | 77079 | Recruiting |
| Endeavor Clinical Trials | San Antonio | Texas | 78240 | Recruiting |
| Tekton Research - Fredericksburg Road | San Antonio | Texas | 78258 | Completed |
| Texas Valley Clinical Research | Weslaco | Texas | 78596 | Recruiting |
| Sovah Clinical Research-River District | Danville | Virginia | 24541 | Recruiting |
| Central Washington Health Services Association d/b/a Confluence Health | Wenatchee | Washington | 98801 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06143956, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 5, 2026 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06143956 live on ClinicalTrials.gov.