MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)
Public ClinicalTrials.gov record NCT06152575. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 3, OPEN-LABEL STUDY OF ELRANATAMAB MONOTHERAPY VERSUS ELOTUZUMAB, POMALIDOMIDE, DEXAMETHASONE (EPd) OR POMALIDOMIDE, BORTEZOMIB, DEXAMETHASONE (PVd) OR CARFILZOMIB, DEXAMETHASONE (Kd) IN PARTICIPANTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA WHO RECEIVED PRIOR ANTI-CD38 DIRECTED THERAPY
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to learn about the study medicine called elranatamab.This study aims to compare elranatamab to other medicines for the treatment of MM (a type of cancer). This study is seeking participants who: * Are 18 years of age or older and have MM. * Have received treatments before for MM. * Have MM that has returned or not responded to their most recent treatment. Half of the participants will receive elranatamab. The other half of participants will receive a combination therapy selected by the study doctor. The selected combination therapy will include 2 to 3 different medicines commonly used to treat MM. Elranatamab will be given as a shot under the skin at the study clinic about once a week. This may change to a smaller number of shots later in the study. The medicines in the combination therapy will be taken by mouth (at home or at the study clinic) AND will be given either as: * a shot under the skin at the study clinic * through a needle in the vein at the study clinic The number of times these medicines will be taken depends on what combination therapy the study doctor selects. Participants may continue to receive elranatamab or a combination therapy until their MM is no longer responding. The study team will see how each participant is doing with the study treatment during regular visits at the study clinic. The study team will continue to follow-up with participants after study treatment with telephone contacts (or visits). The study will compare the experiences of people receiving elranatamab to those people receiving a combination therapy. This will help learn about the safety and how effective elranatamab is.
Study identification
- NCT ID
- NCT06152575
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 492 participants
Conditions and interventions
Conditions
Interventions
- Elranatamab Drug
- Elotuzumab Drug
- Pomalidomide Drug
- Dexamethasone Drug
- Bortezomib Drug
- Carfilzomib Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 7, 2024
- Primary completion
- Aug 29, 2026
- Completion
- Dec 29, 2027
- Last update posted
- Aug 23, 2026
2024 – 2027
United States locations
- U.S. sites
- 100
- U.S. states
- 22
- U.S. cities
- 58
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Infirmary Cancer Care | Mobile | Alabama | 36607 | Recruiting |
| Western Regional Medical Center, Inc. dba. City of Hope Phoenix | Goodyear | Arizona | 85338 | Active, not recruiting |
| Beverly Hills Cancer Center | Beverly Hills | California | 90211 | Recruiting |
| Clovis Community Medical Center | Clovis | California | 93611 | Recruiting |
| Community Cancer Institute | Clovis | California | 93611 | Recruiting |
| Clinical Research Advisors (Encino Satellite Location) | Encino | California | 91316 | Recruiting |
| University of California San Francisco | Fresno | California | 93701 | Recruiting |
| Community Regional Medical Center | Fresno | California | 93721 | Recruiting |
| Hoag Health Center Irvine | Irvine | California | 92618 | Active, not recruiting |
| Hoag Hospital Irvine | Irvine | California | 92618 | Active, not recruiting |
| Clinical Research Advisors (Korea Town Satellite Location) | Los Angeles | California | 90020 | Recruiting |
| Clinical Research Advisors (West Hollywood Satellite Location) | Los Angeles | California | 90048 | Recruiting |
| Valkyrie Clinical Trials | Los Angeles | California | 90067 | Recruiting |
| Hoag Memorial Hospital Presbyterian | Newport Beach | California | 92663 | Active, not recruiting |
| Mission Community Hospital (Satellite Site) | Panorama City | California | 91402 | Recruiting |
| University of California Davis (UC Davis) Comprehensive Cancer Center | Sacramento | California | 95817 | Recruiting |
| University of California | Sacramento | California | 95817 | Recruiting |
| UCHealth Poudre Valley Hospital | Fort Collins | Colorado | 80524 | Recruiting |
| UCHealth Harmony | Fort Collins | Colorado | 80528 | Recruiting |
| UCHealth Greeley Hospital | Greeley | Colorado | 80634 | Recruiting |
| UCHealth Longs Peak Hospital | Longmont | Colorado | 80504 | Recruiting |
| UCHealth Longs Peak Medical Center | Longmont | Colorado | 80504 | Recruiting |
| UCHealth - Medical Center of the Rockies | Loveland | Colorado | 80538 | Recruiting |
| Sylvester Comprehensive Cancer Center - The Lennar Foundation Medical Center | Coral Gables | Florida | 33146 | Recruiting |
| University of Miami Hospital and Clinics - Deerfield Beach | Deerfield Beach | Florida | 33442 | Recruiting |
| Sylvester Comprehensive Cancer Center- Doral | Doral | Florida | 33166 | Recruiting |
| Sylvester Comprehensive Cancer Center - Hollywood | Hollywood | Florida | 33021 | Recruiting |
| Sylvester Comprehensive Cancer Center | Miami | Florida | 33136 | Recruiting |
| University of Miami Hospital and Clinics - Griffin Cancer Research Building | Miami | Florida | 33136 | Recruiting |
| University of Miami Hospital and Clinics | Miami | Florida | 33136 | Recruiting |
| Baptist Hospital of Miami | Miami | Florida | 33176 | Recruiting |
| Miami Cancer Institute at Baptist Health, Inc. | Miami | Florida | 33176 | Recruiting |
| Sylvester Comprehensive Cancer Center- Kendall | Miami | Florida | 33176 | Recruiting |
| BRCR Global | Plantation | Florida | 33322 | Recruiting |
| BRCR Medical Center Inc | Plantation | Florida | 33322 | Recruiting |
| Brcr Medical Center, Inc. | Plantation | Florida | 33322 | Recruiting |
| HCA Florida Westside Hospital | Plantation | Florida | 33324 | Recruiting |
| BRCR Medical Center Inc. | Tamarac | Florida | 33321 | Recruiting |
| Endeavor Health - Swedish Hospital | Chicago | Illinois | 60625 | Recruiting |
| Endeavor Health - Evanston Hospital | Evanston | Illinois | 60201 | Recruiting |
| Endeavor Health - Glenbrook Hospital Ambulatory Care Center | Glenview | Illinois | 60026 | Recruiting |
| Endeavor Health - Highland Park Hospital Health Center 1 | Highland Park | Illinois | 60035 | Recruiting |
| Simmons Cancer Institute at SIU | Springfield | Illinois | 62702 | Recruiting |
| Springfield Clinic Main Campus | Springfield | Illinois | 62703 | Recruiting |
| HSHS St. John's Hospital | Springfield | Illinois | 62769 | Recruiting |
| Springfield Memorial Hospital | Springfield | Illinois | 62781 | Recruiting |
| Midwestern Regional Medical Center, Inc. dba City of Hope Chicago | Zion | Illinois | 60099 | Recruiting |
| Community Health Network, Inc. | Indianapolis | Indiana | 46227 | Recruiting |
| Community Health Network, Inc. | Indianapolis | Indiana | 46250 | Recruiting |
| Community Health Network, Inc. | Indianapolis | Indiana | 46256 | Recruiting |
| American Oncology Partners, P.A. Dba MidAmerica Cancer Care | Kansas City | Kansas | 66112 | Recruiting |
| Ascentist Doctors' Hospital | Leawood | Kansas | 66211 | Recruiting |
| American Oncology Partners, P.A. Dba MidAmerica Cancer Care | Merriam | Kansas | 66204 | Recruiting |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | Recruiting |
| BIDMC Research Pharmacy | Boston | Massachusetts | 02215 | Recruiting |
| American Oncology Partners, P.A. Dba MidAmerica Cancer Care | Belton | Missouri | 64012 | Recruiting |
| MIVA Medical | Independence | Missouri | 64057 | Recruiting |
| Kansas City VA Medical Center | Kansas City | Missouri | 64128 | Recruiting |
| American Oncology Partners, P.A. Dba MidAmerica Cancer Care | Kansas City | Missouri | 64132 | Recruiting |
| Bryan Medical Center | Lincoln | Nebraska | 68506 | Recruiting |
| NHO Revive Research Institute, LLC | Lincoln | Nebraska | 68506 | Recruiting |
| Atlantic Health System Morristown Medical Center | Morristown | New Jersey | 07960 | Recruiting |
| WMCHealth Advanced Physician Services | Hawthorne | New York | 10532 | Active, not recruiting |
| Northwell Health/ RJ Zuckerberg Cancer Center | Lake Success | New York | 11042 | Recruiting |
| North Shore University Hospital | Manhasset | New York | 11030 | Recruiting |
| Long Island Jewish Medical Center | New Hyde Park | New York | 11040 | Recruiting |
| Westchester Medical Center | Valhalla | New York | 10595 | Active, not recruiting |
| Sanford Fargo Medical Center | Fargo | North Dakota | 58102 | Recruiting |
| Oncology Hematology Care Clinical Trials, LLC | Cincinnati | Ohio | 45211 | Recruiting |
| TriHealth Cancer Institute-Good Samaritan Hospital | Cincinnati | Ohio | 45220 | Recruiting |
| Oncology Hematology Care Clinical Trials, LLC | Cincinnati | Ohio | 45236 | Recruiting |
| The Jewish Hospital | Cincinnati | Ohio | 45236 | Recruiting |
| Oncology Hematology Care Clinical Trials, LLC | Cincinnati | Ohio | 45242 | Recruiting |
| TriHealth Cancer Institute- Thomas Comprehensive Care Center | Cincinnati | Ohio | 45242 | Recruiting |
| Oncology Hematology Care Clinical Trials, LLC | Cincinnati | Ohio | 45245 | Recruiting |
| Cleveland Clinic | Cleveland | Ohio | 44195 | Recruiting |
| AHN West Penn Hospital | Pittsburgh | Pennsylvania | 15224 | Recruiting |
| Rodhe Island Hospital | Providence | Rhode Island | 02903 | Recruiting |
| The Miriam Hospital | Providence | Rhode Island | 02906 | Recruiting |
| St Francis Cancer Center | Greenville | South Carolina | 29607 | Active, not recruiting |
| Ascension St. Thomas Hospital | Nashville | Tennessee | 37203 | Recruiting |
| Tennessee Oncology, PLLC - Investigational Drug Services | Nashville | Tennessee | 37203 | Recruiting |
| Tennessee Oncology, PLLC - Nashville Elliston Place Plaza Center for Blood Cancers | Nashville | Tennessee | 37203 | Recruiting |
| Tennessee Oncology, PLLC - Nashville Elliston Place Plaza DDU | Nashville | Tennessee | 37203 | Recruiting |
| Tennessee Oncology, PLLC - Nashville Elliston Place Plaza Medical Oncology & Hematology | Nashville | Tennessee | 37203 | Recruiting |
| Baylor University Medical Center, Investigational Drug Services, Department of Pharmacy | Dallas | Texas | 75246 | Recruiting |
| Baylor University Medical Center | Dallas | Texas | 75246 | Recruiting |
| Houston Methodist Cancer Center Infusion | Houston | Texas | 77030 | Recruiting |
| Houston Methodist Hospital - Department of Pharmacy | Houston | Texas | 77030 | Recruiting |
| Houston Methodist Hospital Cancer Center | Houston | Texas | 77030 | Recruiting |
| Houston Methodist Clear Lake Hospital (St. John) | Houston | Texas | 77058 | Recruiting |
| Houston Methodist Willowbrook Hospital | Houston | Texas | 77070 | Recruiting |
| Houston Methodist West Hospital | Houston | Texas | 77094 | Recruiting |
| Joe Arrington Cancer Research and Treatment Center | Lubbock | Texas | 79410 | Recruiting |
| Houston Methodist Sugar Land Hospital | Sugar Land | Texas | 77479 | Recruiting |
| Baylor Scott & White Medical Center - Temple | Temple | Texas | 76508 | Recruiting |
| Houston Methodist The Woodlands Hospital | The Woodlands | Texas | 77385 | Recruiting |
| WVU Cancer Institute | Morgantown | West Virginia | 26506 | Recruiting |
| University of Wisconsin Carbone Cancer Center - Eastpark Medical Center | Madison | Wisconsin | 53718 | Recruiting |
| University of Wisconsin Carbone Cancer Center-University Hospital | Madison | Wisconsin | 53792 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 170 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06152575, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 23, 2026 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06152575 live on ClinicalTrials.gov.