ClinicalTrials.gov record
Efficacy and Safety of Lorundrostat in Subjects With Uncontrolled and Resistant Hypertension
ClinicalTrials.gov ID: NCT06153693
Public ClinicalTrials.gov record NCT06153693. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo Controlled, Parallel Arm, Multicenter Phase 3 Study to Evaluate the Efficacy and Safety of Lorundrostat in Subjects With Uncontrolled and Resistant Hypertension
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 3 trial to evaluate the BP-lowering effect of lorundrostat (an aldosterone synthase inhibitor) in subjects with uncontrolled and resistant hypertension taking between 2 and 5 anti-hypertensive (AHT) medications.
Study identification
- NCT ID
- NCT06153693
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,083 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 22, 2023 (Actual)
- Primary completion
- Dec 10, 2024 (Actual)
- Completion
- Jan 24, 2025 (Actual)
- Last update posted
- May 1, 2026
2023 – 2025
United States locations
- U.S. sites
- 87
- U.S. states
- 25
- U.S. cities
- 77
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Advanced Cardiovascular, LLC - Alexander City Office | Alexander City | Alabama | 35010 | — |
| Central Research Associates, Inc | Birmingham | Alabama | 35205 | — |
| Cardiology, P.C. | Birmingham | Alabama | 35211-1309 | — |
| Synexus (Radiant Research, Inc) - Alabama - Simon Williamson Clinic Location | Birmingham | Alabama | 35211 | — |
| G & L Research LLC - Foley | Foley | Alabama | 36535 | — |
| Accel Research Sites (ARS) - Birmingham Clinical Research Unit | Vestavia Hills | Alabama | 35216 | — |
| Del Sol Research | Tucson | Arizona | 85715 | — |
| Entertainment Medical Group, Inc. | Beverly Hills | California | 90211 | — |
| Amicis Research Center - Granada Hills | Granada Hills | California | 91344 | — |
| Amicis Research Center - Northridge | Granada Hills | California | 91344 | — |
| Marvel Clinical Research, LLC | Huntington Beach | California | 92647 | — |
| Amicis Research Center | Northridge | California | 91324 | — |
| Pasadena Clinical Trials | Pasadena | California | 91101 | — |
| Empire Clinical Research (ECR) | Pomona | California | 91767 | — |
| Clinical Trials Research (CTR) - Sacramento | Sacramento | California | 95821 | — |
| North America Research Institute | San Dimas | California | 91773 | — |
| Amicis Research Center - Valencia | Valencia | California | 91355 | — |
| CMR of Greater New Haven | Hamden | Connecticut | 06517 | — |
| Chase Medical Research, LLC - Hamden | Waterbury | Connecticut | 06708-3346 | — |
| Indago Research and Health Center | Hialeah | Florida | 33012 | — |
| Clinical Neuroscience Solutions (CNS Healthcare) - Jacksonville | Jacksonville | Florida | 32256 | — |
| Nuovida Research Center Corp | Miami | Florida | 33175 | — |
| Clinical Neuroscience Solutions (CNS Healthcare) - Orlando Research Center | Orlando | Florida | 32801 | — |
| AES Orlando | Orlando | Florida | 32806 | — |
| Patron Medical - Andres Patron D.O. (Patron Ventures, LLC) | Pembroke Pines | Florida | 33026 | — |
| Pines Care Research Center, LLC | Pembroke Pines | Florida | 33026 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| Clinical Research of West Florida (CRWF) - Clearwater | Tampa | Florida | 33606 | — |
| AES The Villages | The Villages | Florida | 32162 | — |
| Morehouse School of Medicine (MSM) | Atlanta | Georgia | 30310-1458 | — |
| ClinCept, LLC | Columbus | Georgia | 31904 | — |
| Accel Research Sites- Decatur | Decatur | Georgia | 30030 | — |
| Georgia Clinical Research Center, Inc | Lawrenceville | Georgia | 30044 | — |
| Elite Clinical Trials | Blackfoot | Idaho | 83221 | — |
| Rocky Mountain Diabetes Center | Idaho Falls | Idaho | 83404-7596 | — |
| Solaris Clinical Research (SCR) | Meridian | Idaho | 83616 | — |
| Synexus (Radiant Research, Inc) - Chicago | Chicago | Illinois | 60602 | — |
| Healthcare Research Network-Chicago, Illinois (Flossmoor) Location | Flossmoor | Illinois | 60422 | — |
| Koch Family Medicine, S.C. | Morton | Illinois | 61550 | — |
| Southern Illinois University School of Medicine - SIU Clinics - SIU Internal Medicine | Springfield | Illinois | 62702 | — |
| Investigators Research Group LLC | Brownsburg | Indiana | 46112 | — |
| Franciscan Physician Network | Indianapolis | Indiana | 46237-6345 | — |
| ASHA Clinical Research- Munster, LLC | Munster | Indiana | 46321 | — |
| Synexus (Radiant Research, Inc) - Evansville | Newburgh | Indiana | 47630 | — |
| Louisville Metabolic and Atherosclerosis Research Center (L-MARC) | Louisville | Kentucky | 40213 | — |
| Tulane Doctors - Heart & Vascular - Metairie | New Orleans | Louisiana | 70112-2600 | — |
| The Alliance for Multispecialty Research LLC (AMR) - Louisiana | New Orleans | Louisiana | 70119 | — |
| Northwest Louisiana Nephrology, LLC - Shreveport | Shreveport | Louisiana | 71101 | — |
| Grace Research, LLC | Shreveport | Louisiana | 71115 | — |
| Boston Clinical Trials (BCT) | Boston | Massachusetts | 02131 | — |
| ActivMed Practices and Research | Methuen | Massachusetts | 01844 | — |
| Hattiesburg Clinic - Medisync Clinical Research | Petal | Mississippi | 39465 | — |
| Healthcare Research Network-Hazelwood | Hazelwood | Missouri | 63042 | — |
| Clinical Research Consultants (CRC) - Kansas City | Kansas City | Missouri | 64111 | — |
| Quality Clinical Research Inc. (QCR) - Omaha | Omaha | Nebraska | 68114 | — |
| Synexus (Radiant Research, Inc) - Nevada - Rita B. Chuang, MD | Henderson | Nevada | 89052 | — |
| Sierra Clinical Research-Las Vegas | Las Vegas | Nevada | 89106 | — |
| Renown Regional Medical Center (Washoe Medical Center) | Reno | Nevada | 89502 | — |
| Synexus (Radiant Research, Inc) - New York | Jamaica | New York | 11432 | — |
| North Shore Diabetes and Endocrine Associates (NSDEA) - New Hyde Park | New Hyde Park | New York | 11042-1214 | — |
| Columbia University | New York | New York | 10032-3725 | — |
| Randolph Health Internal Medicine/ Triad Internal Medicine | Asheboro | North Carolina | 272205 | — |
| East Carolina University (ECU) Physicians - East Carolina Heart Institute - East Carolina University Location | Greenville | North Carolina | 27834 | — |
| Physicians East, P.A. - Endocrinology | Greenville | North Carolina | 27834 | — |
| Carteret Medical Group - Morehead City | Morehead City | North Carolina | 28557 | — |
| Lucas Research, Inc. (Diabetes & Endocrinology Consultants PC) (DEC) | New Bern | North Carolina | 28562 | — |
| Diabetes & Endocrinology Associates of Stark County | Canton | Ohio | 44718 | — |
| Lynn Institute of Norman (LION Research) | Norman | Oklahoma | 73072 | — |
| Valley Kidney Specialists PC - Allentown Cedar Crest | Bethlehem | Pennsylvania | 18017 | — |
| Preferred Primary Care Physicians - Pleasant Hills - Curry Hollow Rd Location | Pittsburgh | Pennsylvania | 15236 | — |
| Preferred Primary Care Physicians (PPCP) - Uniontown - Jacob Murphy Lane Location | Uniontown | Pennsylvania | 15401 | — |
| Chattanooga Medical Research (CMR), LLC | Chattanooga | Tennessee | 37403 | — |
| The Alliance for Multispecialty Research LLC (AMR) - Knoxville (Volunteer Research Group) | Knoxville | Tennessee | 37920 | — |
| Clinical Neuroscience Solutions, Inc | Memphis | Tennessee | 38119 | — |
| Punzi Medical Center and Trinity Hypertension Research Institute | Carrollton | Texas | 75006 | — |
| AES Dallas Fort Worth | Dallas | Texas | 75234 | — |
| Synergy Groups Medical | Houston | Texas | 77036 | — |
| Juno Research, LLC | Houston | Texas | 77054 | — |
| Discovery Clinical Trials (DCT) - McAllen | McAllen | Texas | 78503 | — |
| Synergy Groups Medical - Missouri City | Missouri City | Texas | 35010 | — |
| North Texas Family Medicine (NTFM) - Plano Office | Plano | Texas | 75093 | — |
| Sun Research Institute (SRI) - San Antonio | San Antonio | Texas | 78215 | — |
| Discovery Clinical Trials (DCT) - San Antonio | San Antonio | Texas | 78258 | — |
| Global AES - Salt Lake City | Salt Lake City | Utah | 84106 | — |
| Velocity Clinical Research - Salt Lake City (Advanced Clinical Research) | West Jordan | Utah | 84088 | — |
| Burke Internal Medicine | Burke | Virginia | 22015 | — |
| Eastern VA Medical School | Norfolk | Virginia | 23501 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 97 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06153693, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 1, 2026 · Synced Oct 26, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06153693 live on ClinicalTrials.gov.