A Study of Raludotatug Deruxtecan (R-DXd) in Subjects With Platinum-resistant, High-grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

ClinicalTrials.gov ID: NCT06161025

Public ClinicalTrials.gov record NCT06161025. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 8:22 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2/3, Multicenter, Randomized Study of Raludotatug Deruxtecan (R-DXd), a CDH6-directed Antibody-drug Conjugate, in Subjects With Platinum-resistant, High-grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Study identification

NCT ID: NCT06161025
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2, Phase 3
Lead sponsor: Daiichi Sankyo; Industry
Enrollment: 860 participants

Conditions and interventions

Conditions

Solid Cancer

Interventions

PLD Drug
Paclitaxel Drug
R-DXd Drug
Topotecan Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Feb 26, 2024
Primary completion: Feb 28, 2028
Completion: Apr 29, 2030
Last update posted: Jan 11, 2026

2024 – 2030

United States locations

U.S. sites: 39
U.S. states: 16
U.S. cities: 31

Facility	City	State	ZIP	Site status
Alaska Women's Cancer Care	Anchorage	Alaska	99508	Active, not recruiting
Yale University School of Medicine	New Haven	Connecticut	06520	Recruiting
Sylvester Comprehensive Cancer Center at Lennar	Coral Gables	Florida	33146	Active, not recruiting
Sylvester Comprehensive Cancer Center at Deerfield Beach	Deerfield Beach	Florida	33442	Active, not recruiting
Florida Cancer Specialists	Lake Mary	Florida	32746	Active, not recruiting
Sylvester Cancer Center	Miami	Florida	33136	Active, not recruiting
Mount Sinai Comprehensive Cancer Center	Miami Beach	Florida	33140	Active, not recruiting
Sylvester Comprehensive Cancer Center at Plantation	Plantation	Florida	33324	Active, not recruiting
Community MD Anderson Cancer Center- East	Indianapolis	Indiana	46219	Active, not recruiting
Community MD Anderson Cancer Center- South	Indianapolis	Indiana	46227	Active, not recruiting
Community Health Network - MD Anderson	Indianapolis	Indiana	46250	Recruiting
St. Elizabeth Medical Center	Edgewood	Kentucky	41017	Recruiting
Washington University School of Medicine Obstetrics and Gynecology	St Louis	Missouri	63110	Recruiting
Valley Health System	Paramus	New Jersey	07652	Active, not recruiting
Holy Name	Teaneck	New Jersey	07666	Active, not recruiting
NHPP Imbert	Bay Shore	New York	11706	Active, not recruiting
Northwell Health, LLC PRIME	Lake Success	New York	11042	Active, not recruiting
Perlmutter Cancer Center at NYU Langone Hospital- Long Island	Mineola	New York	11501	Active, not recruiting
NYU Langone Health	New York	New York	10016	Active, not recruiting
NHPP LHH	New York	New York	10065	Active, not recruiting
Duke Women's Cancer Care- Raleigh	Durham	North Carolina	27607	Active, not recruiting
Duke Cancer Center	Durham	North Carolina	27710	Active, not recruiting
Ohio State University Wexner Medical Center	Hilliard	Ohio	43026	Active, not recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
Oklahoma Cancer Specialists and Research Institute	Tulsa	Oklahoma	12967	Recruiting
Perelman School of Medicine at the University of Pennsylvania	Philadelphia	Pennsylvania	19104-4238	Active, not recruiting
Medical University of South Carolina (MUSC)	Charleston	South Carolina	29425	Recruiting
Sanford Cancer Center Gynecologic Oncology	Sioux Falls	South Dakota	57104	Active, not recruiting
Texas Oncology-Bedford	Bedford	Texas	76022	Active, not recruiting
Houston Area Locations- Woodlands	Conroe	Texas	77384	Active, not recruiting
Texas Oncology-Presbyterian Cancer Center Dallas	Dallas	Texas	75231	Active, not recruiting
Texas Oncology-Baylor Charles A. Sammons Cancer Center	Dallas	Texas	75246	Active, not recruiting
Texas Oncology Paris	Fort Worth	Texas	76104	Active, not recruiting
Houston Methodist Hospital	Houston	Texas	77030	Recruiting
University of Texas - MD Anderson	Houston	Texas	77030	Active, not recruiting
Houston Area Locations- Sugar Land	Houston	Texas	77079	Active, not recruiting
Houston Area Locations- West Houston	Houston	Texas	77079	Active, not recruiting
Houston Area Locations- League City	League City	Texas	77573	Active, not recruiting
University of Washington - Seattle Cancer Care Alliance	Seattle	Washington	98109	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 81 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06161025, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jan 11, 2026 · Synced May 6, 2026

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The complete protocol, eligibility criteria, and contact information for NCT06161025 live on ClinicalTrials.gov.

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