Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC

ClinicalTrials.gov ID: NCT06162221

Public ClinicalTrials.gov record NCT06162221. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 20, 2026, 11:10 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Platform Study of RAS(ON) Inhibitors in Patients With RAS-Mutated Non-Small Cell Lung Cancer (NSCLC)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this platform study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of novel RAS(ON) inhibitors as a monotherapy or combined with Standard(s) of Care (SOC) or with each other. The first four subprotocols include the following: Subprotocol A: RMC-6291 +/- RMC-6236 + SOC Subprotocol B: RMC-6236 + SOC Subprotocol C: RMC-9805 +/- RMC-6236 + SOC Subprotocol D: RMC-9805

Study identification

NCT ID: NCT06162221
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: Revolution Medicines, Inc.; Industry
Enrollment: 616 participants

Conditions and interventions

Conditions

Interventions

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jan 18, 2024 (Actual)
Primary completion: Jun 2027 (Estimated)
Completion: Dec 2028 (Estimated)
Last update posted: Oct 19, 2026

2024 – 2028

United States locations

U.S. sites: 29
U.S. states: 15
U.S. cities: 27

Facility	City	State	ZIP	Site status
Banner MD Anderson Cancer Center	Gilbert	Arizona	85234	Recruiting
City of Hope - Duarte	Duarte	California	91010	Active, not recruiting
City of Hope - Lennar	Irvine	California	92618	Active, not recruiting
University of California Los Angeles	Los Angeles	California	90095	Active, not recruiting
UC Davis, Davis Comprehensive Cancer Center	Sacramento	California	95817	Recruiting
University of California, San Diego Moores Cancer Center	San Diego	California	92037	Recruiting
UCSF Medical Center - Mission Bay	San Francisco	California	94158	Recruiting
Stanford University - Stanford Cancer Institute	Stanford	California	94305	Recruiting
Kaiser Permanente	Vallejo	California	94589	Active, not recruiting
Georgetown University Medical Center	Washington D.C.	District of Columbia	20007	Recruiting
Boca Raton Clinical Research Associates	Plantation	Florida	33322	Recruiting
Cancer Specialists of North Florida	Saint Augustine	Florida	32086	Active, not recruiting
H Lee Moffitt Cancer Center and Research Institute	Tampa	Florida	33612	Recruiting
Dana Farber Cancer Institute	Boston	Massachusetts	02215	Recruiting
Henry Ford Cancer - Detroit (Brigitte Harris Cancer Pavilion)	Detroit	Michigan	48202	Active, not recruiting
Intermountain Health - St. Vincent Frontier Cancer Center	Billings	Montana	59102	Active, not recruiting
Nebraska Cancer Specialist	Grand Island	Nebraska	68803	Recruiting
New York University Langone Health	New York	New York	10016	Recruiting
Icahn School of Medicine at Mount Sinai	New York	New York	10029	Active, not recruiting
Columbia University Medical Center	New York	New York	10032	Recruiting
Clinical Research Alliance	Westbury	New York	11590	Active, not recruiting
University Hospitals Cleveland Medical Center	Cleveland	Ohio	44106	Recruiting
UPMC Hillman Cancer Center	Pittsburgh	Pennsylvania	15232	Recruiting
Baptist Medical Center	Memphis	Tennessee	38120	Recruiting
Tennessee Oncology	Nashville	Tennessee	37203	Recruiting
The University of Texas MD Anderson Cancer Center	Houston	Texas	77030	Recruiting
NEXT Oncology Dallas	Irving	Texas	75039	Recruiting
NEXT Oncology Virginia	Fairfax	Virginia	22031	Recruiting
Fred Hutchinson Cancer Research Center	Seattle	Washington	98109	Active, not recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 69 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06162221, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Oct 19, 2026 · Synced Oct 20, 2026

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The complete public registry record, listed eligibility criteria, and available contact information for NCT06162221 live on ClinicalTrials.gov.

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