ClinicalTrials.gov record
Evaluation of Efficacy and Safety of VX-548 for Painful Lumbosacral Radiculopathy (PLSR)
ClinicalTrials.gov ID: NCT06176196
Public ClinicalTrials.gov record NCT06176196. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 17, 2026, 5:13 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized, Double-blind, Placebo-controlled, Parallel-design Study of the Efficacy and Safety of VX-548 in Subjects With Painful Lumbosacral Radiculopathy
Study identification
- NCT ID
- NCT06176196
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Vertex Pharmaceuticals Incorporated
- Industry
- Enrollment
- 218 participants
Conditions and interventions
Conditions
Interventions
- Placebo Drug
- VX-548 Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 12, 2023
- Primary completion
- Oct 1, 2024
- Completion
- Oct 15, 2024
- Last update posted
- Sep 30, 2025
2023 – 2024
United States locations
- U.S. sites
- 54
- U.S. states
- 21
- U.S. cities
- 51
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Hope Research Institute | Phoenix | Arizona | 85018 | — |
| Arizona Research Center | Phoenix | Arizona | 85053 | — |
| Trovare Clinical Research | Bakersfield | California | 93301 | — |
| Velocity Clinical Research - Banning | Banning | California | 92220 | — |
| Velocity Clinical Research - San Diego | La Mesa | California | 91942 | — |
| Probe Clinical Research | Riverside | California | 92501 | — |
| Pain Management and Injury Relief | Thousand Oaks | California | 91320 | — |
| Visionary Investigators Network | Aventura | Florida | 33180 | — |
| Nature Coast Clinical Research - Crystal River | Crystal River | Florida | 34429 | — |
| JY Research Institute | Cutler Bay | Florida | 33189 | — |
| Fleming Island Center for Clinical Research | Fleming Island | Florida | 32003 | — |
| Convenient Medical Research | Hialeah | Florida | 33013 | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| L&C Professional Medical Research Institute | Miami | Florida | 33144 | — |
| Medical Research of Westchester | Miami | Florida | 33165 | — |
| ARSN-Brain and Spine Institute | Port Orange | Florida | 32127 | — |
| Accel Research Site - St. Petersburg/Largo | Seminole | Florida | 33777 | — |
| Atlanta Center for Medical Research | Atlanta | Georgia | 30331 | — |
| ClinCept Clinical Research | Columbus | Georgia | 31904 | — |
| Accel Research Sites - Neurostudies | Decatur | Georgia | 30030 | — |
| Velocity Clinical Research - Savannah Neurology Specialists | Savannah | Georgia | 31406 | — |
| Velocity Clinical Research - Savannah | Savannah | Georgia | 31406 | — |
| Center for Pain Management and Rehab | Stockbridge | Georgia | 30281 | — |
| Velocity Clinical Research - Boise | Meridian | Idaho | 83642 | — |
| Healthcare Research Network II, LLC | Flossmoor | Illinois | 60422 | — |
| Essential Concepts Research Solutions | Palos Hills | Illinois | 60465 | — |
| AMR Wichita East, KS | Wichita | Kansas | 67207 | — |
| Velocity Clinical Research - Rockville | Rockville | Maryland | 20854 | — |
| Brigham and Women's Hospital (BWH) | Boston | Massachusetts | 02115 | — |
| MedVadis Research Coorporation | Waltham | Massachusetts | 02451 | — |
| St. Louis Pain Consultants | Chesterfield | Missouri | 63017 | — |
| Healthcare Research Network | Hazelwood | Missouri | 63042 | — |
| Be Well Clinical Studies, LLC | Lincoln | Nebraska | 68516 | — |
| Synexus Clinical Research - Henderson | Henderson | Nevada | 89052 | — |
| AMR Las Vegas (Clinical Research Consortium) | Las Vegas | Nevada | 89119 | — |
| Albany Medical Center | Albany | New York | 12208 | — |
| AES New York | New York | New York | 10017 | — |
| Velocity Clinical Research - Cincinnati | Cincinnati | Ohio | 45242 | — |
| META Medical Research Institute | Dayton | Ohio | 45432 | — |
| NexGen Research | Lima | Ohio | 45805 | — |
| Clinical Investigations LLC. | Edmond | Oklahoma | 73034 | — |
| AMR Norman | Norman | Oklahoma | 73069 | — |
| Pacific Sports and Spine | Eugene | Oregon | 97404 | — |
| Velocity Clinical Research - Grants Pass | Grants Pass | Oregon | 97527 | — |
| Velocity Clinical Research - Providence | East Greenwich | Rhode Island | 02818 | — |
| Clinical Trials of South Carolina - Charleston | Charleston | South Carolina | 29406 | — |
| AES Dallas Forth Worth | Dallas | Texas | 75234 | — |
| Expert Pain | Houston | Texas | 77079 | — |
| Lubbock Spine Institute | Lubbock | Texas | 79410 | — |
| Be Well Clinical Studies - Austin | Round Rock | Texas | 78681 | — |
| JBR Clinical Research | Salt Lake City | Utah | 84107 | — |
| Velocity Clinical Research - Hampton | Hampton | Virginia | 23666 | — |
| AMR Norfolk | Norfolk | Virginia | 23502 | — |
| Velocity Clinical Research - Portsmouth | Portsmouth | Virginia | 23703 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06176196, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 30, 2025 · Synced May 17, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06176196 live on ClinicalTrials.gov.