Study of ALXN2220 Versus Placebo in Adults With ATTR-CM
Public ClinicalTrials.gov record NCT06183931. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Amyloid Depleter ALXN2220 in Adult Participants With Transthyretin Amyloid Cardiomyopathy (ATTR-CM)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of this study is to access the efficacy of ALXN2220 in the treatment of adult participants with ATTR-CM by evaluating the difference between the ALXN2220 and placebo groups as assessed by the total occurrences of all-cause mortality (ACM) and cardiovascular (CV) clinical events.
Study identification
- NCT ID
- NCT06183931
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,181 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 90 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 11, 2024 (Actual)
- Primary completion
- Dec 6, 2027 (Estimated)
- Completion
- Apr 5, 2028 (Estimated)
- Last update posted
- Aug 10, 2026
2024 – 2028
United States locations
- U.S. sites
- 36
- U.S. states
- 21
- U.S. cities
- 33
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Irvine | California | 92614 | — |
| Research Site | La Jolla | California | 92037 | — |
| Research Site | Palo Alto | California | 94304 | — |
| Research Site | San Francisco | California | 94143 | — |
| Research Site | Aurora | Colorado | 80045 | — |
| Research Site | Washington D.C. | District of Columbia | 20010 | — |
| Research Site | Jacksonville | Florida | 32224 | — |
| Research Site | Weston | Florida | 33331 | — |
| Research Site | Atlanta | Georgia | 30309 | — |
| Research Site | Atlanta | Georgia | 30322 | — |
| Research Site | Chicago | Illinois | 60611 | — |
| Research Site | Indianapolis | Indiana | 46202 | — |
| Research Site | Boston | Massachusetts | 02115 | — |
| Research Site | Boston | Massachusetts | 02118 | — |
| Research Site | Kansas City | Missouri | 64111 | — |
| Research Site | St Louis | Missouri | 63110 | — |
| Research Site | New York | New York | 10016 | — |
| Research Site | New York | New York | 10032 | — |
| Research Site | Stony Brook | New York | 11794 | — |
| Research Site | Chapel Hill | North Carolina | 27599 | — |
| Research Site | Durham | North Carolina | 27705 | — |
| Research Site | Cleveland | Ohio | 44195 | — |
| Research Site | Columbus | Ohio | 43210 | — |
| Research Site | Portland | Oregon | 97239 | — |
| Research Site | Danville | Pennsylvania | 17822 | — |
| Research Site | Philadelphia | Pennsylvania | 19104 | — |
| Research Site | Charleston | South Carolina | 29425 | — |
| Research Site | Greenville | South Carolina | 29605 | — |
| Research Site | Memphis | Tennessee | 38120 | — |
| Research Site | Fort Worth | Texas | 76104 | — |
| Research Site | Houston | Texas | 77030 | — |
| Research Site | Salt Lake City | Utah | 84132 | — |
| Research Site | Falls Church | Virginia | 22042 | — |
| Research Site | Richmond | Virginia | 23298 | — |
| Research Site | Seattle | Washington | 98195 | — |
| Research Site | Madison | Wisconsin | 53705 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 177 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06183931, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 10, 2026 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06183931 live on ClinicalTrials.gov.