Study of Subcutaneous Epcoritamab in Combination With Intravenous Rituximab and Oral Lenalidomide (R2) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Previously Untreated Follicular Lymphoma

ClinicalTrials.gov ID: NCT06191744

Public ClinicalTrials.gov record NCT06191744. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 10, 2026, 8:53 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Multicenter, Randomized, Open-Label Trial to Evaluate the Safety and Efficacy of Epcoritamab + Rituximab and Lenalidomide (R2) Compared to Chemoimmunotherapy in Previously Untreated Follicular Lymphoma (EPCORE™FL-2)

Study identification

NCT ID: NCT06191744
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Genmab; Industry
Enrollment: 1,095 participants

Conditions and interventions

Conditions

Follicular Lymphoma (FL)

Interventions

Bendamustine Drug
Cyclophosphamide Drug
Doxorubicin Drug
Epcoritamab Drug
Lenalidomide Drug
Obinutuzumab Drug
Prednisone Drug
Rituximab Drug
Vincristine Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Feb 4, 2024
Primary completion: Oct 31, 2037
Completion: Oct 31, 2037
Last update posted: May 5, 2026

2024 – 2037

United States locations

U.S. sites: 58
U.S. states: 25
U.S. cities: 51

Facility	City	State	ZIP	Site status
UCSF Fresno /ID# 264712	Fresno	California	93701-2302	Recruiting
Scripps Mercy Hospital /ID# 265393	San Diego	California	92103	Recruiting
Sansum Clinic Research /ID# 261596	Santa Barbara	California	93105	Recruiting
Rocky Mountain Cancer Centers - Boulder /ID# 261203	Boulder	Colorado	80303	Recruiting
Christiana Care Health Service /ID# 261207	Newark	Delaware	19713	Recruiting
Cancer Specialists of North Florida - Jacksonville - AC Skinner Parkway /ID# 262445	Jacksonville	Florida	32256	Recruiting
Advent Health /ID# 261578	Orlando	Florida	32803	Recruiting
Orlando Health Cancer Institute /ID# 260983	Orlando	Florida	32806	Recruiting
Moffitt Cancer Center /ID# 259487	Tampa	Florida	33612-9416	Recruiting
Beacon Cancer Care /ID# 260670	Coeur d'Alene	Idaho	83814	Recruiting
Northwestern Medicine - Northwestern Memorial Hospital /ID# 259814	Chicago	Illinois	60611	Recruiting
Cancer Care Specialists Of Central Illinois /ID# 272464	Decatur	Illinois	62526	Recruiting
Loyola University /ID# 259462	Maywood	Illinois	60153	Recruiting
Illinois Cancer Care, PC /ID# 261526	Peoria	Illinois	61615	Recruiting
Fort Wayne Medical Oncology and Hematology- South Office /ID# 259583	Fort Wayne	Indiana	46804	Recruiting
University of Iowa Health Care /ID# 262132	Des Moines	Iowa	50314-3017	Recruiting
University of Louisville Hospital /ID# 260544	Louisville	Kentucky	40202	Recruiting
Norton Cancer Institute - St. Matthews /ID# 261076	Louisville	Kentucky	40207	Recruiting
New England Cancer Specialists - Westbrook /ID# 260672	Westbrook	Maine	04092	Recruiting
University of Maryland, Baltimore /ID# 259538	Baltimore	Maryland	21201	Recruiting
Center for Cancer and Blood Disorders-American Oncology Partners of Maryland /ID# 259476	Bethesda	Maryland	20817	Recruiting
St. Luke's Hospital - Chesterfield /ID# 260489	Chesterfield	Missouri	63017	Recruiting
Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana /ID# 260006	Billings	Montana	59102	Recruiting
Nebraska Cancer Specialists (NCS) - Regional Cancer Center - St Francis Location /ID# 262506	Grand Island	Nebraska	68803	Recruiting
NHO - Nebraska Hematology-Oncology /ID# 269692	Lincoln	Nebraska	68506	Recruiting
Nebraska Cancer Specialists - Omaha - Wright Street /ID# 262505	Omaha	Nebraska	68130	Recruiting
University of Nebraska Medical Center /ID# 261996	Omaha	Nebraska	68198	Recruiting
University of New Mexico /ID# 261083	Albuquerque	New Mexico	87102-4517	Recruiting
Presbyterian Kaseman Hospital /ID# 262451	Albuquerque	New Mexico	87110	Recruiting
Presbyterian Rust Medical Center /ID# 262447	Rio Rancho	New Mexico	87124	Recruiting
New York Oncology Hematology - Albany Cancer Center /ID# 261814	Albany	New York	12206-5013	Completed
NYU Langone Hospital - Long Island /ID# 265531	Mineola	New York	11501	Recruiting
NYU Langone Medical Center /ID# 264518	New York	New York	10016-6402	Recruiting
Icahn School of Medicine at Mount Sinai /ID# 259595	New York	New York	10029	Recruiting
New York Oncology Hematology /ID# 270208	Troy	New York	12180	Recruiting
Clinical Research Alliance - Westbury /ID# 261078	Westbury	New York	11590	Recruiting
Novant Health Presbyterian Medical Center /ID# 259740	Charlotte	North Carolina	28204	Recruiting
Novant Health Forsyth Medical Center /ID# 259741	Winston-Salem	North Carolina	27103	Recruiting
Oncology Hematology Care, Inc - Blue Ash /ID# 261204	Cincinnati	Ohio	45252	Recruiting
Taylor Cancer Research Center /ID# 260488	Maumee	Ohio	43537-1921	Completed
Oncology Associates of Oregon, P.C. /ID# 261816	Eugene	Oregon	97401	Recruiting
MUSC Hollings Cancer Center /ID# 259604	Charleston	South Carolina	29425	Recruiting
Prisma Health /ID# 259602	Greenville	South Carolina	29605	Recruiting
Sarah Cannon Research Institute - Tristar Centennial Medical Center /ID# 274985	Nashville	Tennessee	37203	Recruiting
Texas Oncology - Austin Midtown /ID# 261208	Austin	Texas	78705	Recruiting
Texas Oncology- Baylor Charles A. Sammons Cancer Center /ID# 261206	Dallas	Texas	75246-2003	Recruiting
MD Anderson Cancer Center /ID# 260984	Houston	Texas	77030-4000	Recruiting
Oncology Consultants /ID# 268390	Houston	Texas	77030	Recruiting
Joe Arrington Cancer Research /ID# 260382	Lubbock	Texas	79410	Recruiting
Intermountain Healthcare LDS Hospital /ID# 259759	Salt Lake City	Utah	84143	Recruiting
Virginia Cancer Specialists - Fairfax /ID# 261205	Fairfax	Virginia	22031	Recruiting
Oncology and Hematology Associates of Southwest Virginia /ID# 261592	Roanoke	Virginia	98684	Recruiting
Swedish Cancer Institute - Edmonds /ID# 266356	Edmonds	Washington	98026	Recruiting
Swedish Cancer Institute - Issaquah /ID# 266358	Issaquah	Washington	98029	Recruiting
Vista Oncology - East Olympia /ID# 261360	Olympia	Washington	98506-5028	Recruiting
Virginia Mason Hospital & Medical Center /ID# 260549	Seattle	Washington	98101	Recruiting
Swedish Medical Center - Seattle /ID# 260370	Seattle	Washington	98104	Recruiting
Northwest Medical Specialties - Tacoma /ID# 262133	Tacoma	Washington	98405	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 208 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06191744, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 5, 2026 · Synced May 10, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06191744 live on ClinicalTrials.gov.

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