A Study to Learn About Vepdegestrant When Given With PF-07220060 to People With Advanced or Metastatic Breast Cancer.
Public ClinicalTrials.gov record NCT06206837. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
AN INTERVENTIONAL SAFETY AND EFFICACY PHASE 1B/2, OPEN-LABEL STUDY TO INVESTIGATE TOLERABILITY, PK, AND ANTITUMOR ACTIVITY OF VEPDEGESTRANT (ARV-471/PF-07850327), AN ORAL PROTEOLYSIS TARGETING CHIMERA, IN COMBINATION WITH PF-07220060 IN PARTICIPANTS AGED 18 YEARS AND OLDER WITH ER+/HER2- ADVANCED OR METASTATIC BREAST CANCER
Study identification
- NCT ID
- NCT06206837
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- Pfizer
- Industry
- Enrollment
- 71 participants
Conditions and interventions
Conditions
Interventions
- PF-07220060 Drug
- vepdegestrant Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 18, 2024
- Primary completion
- Sep 4, 2025
- Completion
- Sep 6, 2026
- Last update posted
- Feb 26, 2026
2024 – 2026
United States locations
- U.S. sites
- 34
- U.S. states
- 9
- U.S. cities
- 25
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Highlands Oncology | Fayetteville | Arkansas | 72703 | — |
| Highlands Oncology | Rogers | Arkansas | 72758 | — |
| Highlands Oncology Group | Springdale | Arkansas | 72762 | — |
| Hoag Health Center Irvine | Irvine | California | 92618 | — |
| Hoag Hospital Irvine | Irvine | California | 92618 | — |
| Hoag Memorial Hospital Presbyterian | Newport Beach | California | 92663 | — |
| Stanford Cancer Center | Palo Alto | California | 94304 | — |
| Stanford Cancer Institute - Clinical Trials Office | Palo Alto | California | 94304 | — |
| Stanford Women's Cancer Center | Palo Alto | California | 94304 | — |
| UCSF Medical Center at Mission Bay | San Francisco | California | 94158 | — |
| UCHealth Poudre Valley Hospital | Fort Collins | Colorado | 80524 | — |
| UCHealth Harmony | Fort Collins | Colorado | 80528 | — |
| UCHealth Greeley Hospital | Greeley | Colorado | 80634 | — |
| UCHealth - Medical Center of the Rockies | Loveland | Colorado | 80538 | — |
| Smilow Cancer Hospital - Yale New Haven Health | New Haven | Connecticut | 06510 | — |
| Yale - New Haven Hospital - Yale Cancer Center | New Haven | Connecticut | 06510 | — |
| Smilow Cancer Hospital Phase 1 Unit | New Haven | Connecticut | 06511 | — |
| Smilow Cancer Hospital - Trumbull | Trumbull | Connecticut | 06611 | — |
| START Midwest | Grand Rapids | Michigan | 49546 | — |
| MSK Basking Ridge | Basking Ridge | New Jersey | 07920 | — |
| MSK Monmouth | Middletown | New Jersey | 07748 | — |
| MSK Bergen | Montvale | New Jersey | 07645 | — |
| MSK Commack | Commack | New York | 11725 | — |
| MSK Westchester | Harrison | New York | 10604 | — |
| Rockefeller Outpatient Pavilion (53rd Street) | New York | New York | 10022 | — |
| Evelyn H. Lauder Breast and Imaging Center (BAIC). | New York | New York | 10065 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | — |
| MSK Nassau | Uniondale | New York | 11553 | — |
| START San Antonio | San Antonio | Texas | 78229 | — |
| University of Utah, Farmington Health Center | Farmington | Utah | 84025 | — |
| University of Utah, Sugar House Health Center | Salt Lake City | Utah | 84106 | — |
| Huntsman Cancer Institute | Salt Lake City | Utah | 84112 | — |
| South Jordan Health Center - University of Utah | South Jordan | Utah | 84106 | — |
| START Mountain Region | West Valley City | Utah | 84119 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 24 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06206837, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 26, 2026 · Synced May 6, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06206837 live on ClinicalTrials.gov.