A Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients With Early Alzheimer's Disease (BenfoTeam)

ClinicalTrials.gov ID: NCT06223360

Public ClinicalTrials.gov record NCT06223360. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search

ClinicalTrials.gov public records Last synced May 10, 2026, 10:31 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Seamless Phase 2A-Phase 2B Randomized Double-Blind Placebo- Controlled Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients With Early Alzheimer's Disease (BenfoTeam)

Study identification

NCT ID: NCT06223360
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Alzheimer's Disease Cooperative Study (ADCS); Other
Enrollment: 406 participants

Conditions and interventions

Conditions

Alzheimer Disease

Interventions

High Dose Benfotiamine Drug
Low Dose Benfotiamine Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 50 Years to 89 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 27, 2024
Primary completion: Nov 30, 2027
Completion: Nov 30, 2027
Last update posted: Feb 22, 2026

2024 – 2027

United States locations

U.S. sites: 47
U.S. states: 20
U.S. cities: 38

Facility	City	State	ZIP	Site status
St. Joseph's Hospital and Medical Center/Barrow Neurological Institute	Phoenix	Arizona	85013	Recruiting
Perseverance Research Center, LLC	Scottsdale	Arizona	85253	Recruiting
Banner Sun Health Research Institute	Sun City	Arizona	85351	Recruiting
The Neuron Clinic	Chula Vista	California	91910	Recruiting
University of California, Irvine	Irvine	California	92697	Recruiting
Pacific Research Network	Lemon Grove	California	91945	Terminated
University of Southern California	Los Angeles	California	90033	Recruiting
Cedars Sinai, Los Angeles	Los Angeles	California	90048	Recruiting
Syrentis Clinical Research	Santa Ana	California	92705	Recruiting
JEM Research Institute	Atlantis	Florida	33462	Recruiting
Brain Matters Research	Delray Beach	Florida	33445	Recruiting
Neuropsychiatric Research Center of Southwest Florida	Fort Myers	Florida	33912	Recruiting
CCM Clinical Research Group, LLC	Miami	Florida	33133	Recruiting
Gonzalez MD & Aswad MD Health Services	Miami	Florida	33135	Recruiting
Miami Jewish Health	Miami	Florida	33137	Recruiting
Blue Medical Research Inc.	Miami	Florida	33144	Recruiting
Brainstorm Research	Miami	Florida	33176	Recruiting
Brain Matters Research (Kane Center)	Stuart	Florida	34997	Recruiting
Conquest Research	Winter Park	Florida	32789	Recruiting
Emory University Goizueta Alzheimer's Disease Research Center(GADRC)	Atlanta	Georgia	30329	Recruiting
Sandhill Research, LLC d/b/a Accel Research Sites	Decatur	Georgia	30030	Recruiting
Northwestern University Feinberg School of Medicine	Chicago	Illinois	60611	Recruiting
Rush University Medical Center	Chicago	Illinois	60612	Recruiting
Southern Illinois University	Springfield	Illinois	62702	Recruiting
University of Iowa	Iowa City	Iowa	52242	Recruiting
University of Kentucky	Lexington	Kentucky	40504	Recruiting
MedVadis Research	Waltham	Massachusetts	02451	Recruiting
University of Michigan, Ann Arbor	Ann Arbor	Michigan	48109	Recruiting
Rutgers, Robert Wood Johnson Medical School	New Brunswick	New Jersey	08901	Recruiting
Albany Medical College	Albany	New York	12208	Recruiting
Dent Neurologic Institute	Amherst	New York	14226	Recruiting
Integrative Clinical Trials	Brooklyn	New York	11229	Recruiting
Weill Cornell Medical College	New York	New York	10021	Recruiting
Mount Sinai School of Medicine	New York	New York	10029	Recruiting
Columbia University Irving Medical Center	New York	New York	10032	Recruiting
Nathan Kline Institute for Psychiatric Research	New York	New York	10962	Recruiting
SUNY Upstate Medical University	Syracuse	New York	13210	Recruiting
AMC Research LLC, dba Flourish Research	Matthews	North Carolina	28105	Recruiting
Case Western Reserve University	Cleveland	Ohio	44106	Recruiting
Ohio State University	Columbus	Ohio	43221	Recruiting
Oregon Health & Science University (OHSU)	Portland	Oregon	97239	Recruiting
Geisinger Memory and Cognition Center	Wilkes-Barre	Pennsylvania	18711	Recruiting
Rhode Island Hospital	Providence	Rhode Island	02903	Recruiting
Ralph H. Johnson VA Health Care System	Charleston	South Carolina	29401	Recruiting
KCA Neurology	Tennessee City	Tennessee	37067	Recruiting
University of North Texas Health Science Center	Fort Worth	Texas	76107	Recruiting
Froedtert and Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06223360, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Feb 22, 2026 · Synced May 10, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06223360 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →