A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms
Public ClinicalTrials.gov record NCT06223880. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Active-controlled Study of AXS-05 for the Prevention of Relapse of Depressive Symptoms
Study identification
- NCT ID
- NCT06223880
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 4
- Lead sponsor
- Axsome Therapeutics, Inc.
- Industry
- Enrollment
- 350 participants
Conditions and interventions
Conditions
Interventions
- AXS-05 Drug
- Bupropion Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 26, 2023
- Primary completion
- Feb 28, 2026
- Completion
- Feb 28, 2026
- Last update posted
- Jan 22, 2025
2023 – 2026
United States locations
- U.S. sites
- 40
- U.S. states
- 18
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Clinical Research Site | Bellflower | California | 90706 | Recruiting |
| Clinical Research Site | Lafayette | California | 94549 | Recruiting |
| Clinical Research Site | Oceanside | California | 92056 | Recruiting |
| Clinical Research Site | Redlands | California | 92374 | Recruiting |
| Clinical Research Site | Riverside | California | 92506 | Recruiting |
| Clinical Research Site | San Diego | California | 92103 | Recruiting |
| Clinical Research Site | Upland | California | 91786 | Recruiting |
| Clinical Research Site | Brandon | Florida | 33511 | Recruiting |
| Clinical Research Site | Doral | Florida | 33122 | Recruiting |
| Clinical Research Site | Hialeah | Florida | 33012 | Recruiting |
| Clinical Research Site | Jacksonville | Florida | 32256 | Recruiting |
| Clinical Research Site | Miami | Florida | 33122 | Recruiting |
| Clinical Research Site | Orlando | Florida | 32801 | Recruiting |
| Clinical Research Site | Orlando | Florida | 32806 | Recruiting |
| Clinical Research Site | Orlando | Florida | 32807 | Recruiting |
| Clinical Research Site | Atlanta | Georgia | 30331 | Recruiting |
| Clinical Research Site | Chicago | Illinois | 60634 | Recruiting |
| Clinical Research Site | Overland Park | Kansas | 66210 | Recruiting |
| Clinical Research Site | New Orleans | Louisiana | 70115 | Recruiting |
| Clinical Research Site | Boston | Massachusetts | 02131 | Recruiting |
| Clinical Research Site | Saint Charles | Missouri | 63304 | Recruiting |
| Clinical Research Site | Las Vegas | Nevada | 89102 | Recruiting |
| Clinical Research Site | Cherry Hill | New Jersey | 08002 | Recruiting |
| Clinical Research Site | Toms River | New Jersey | 08755 | Recruiting |
| Clinical Research Site | Brooklyn | New York | 11235 | Recruiting |
| Clinical Research Site | Mount Kisco | New York | 10549 | Recruiting |
| Clinical Research Site | New York | New York | 10128 | Recruiting |
| Clinical Research Site | Staten Island | New York | 10314 | Recruiting |
| Clinical Research Site | Hickory | North Carolina | 28601 | Recruiting |
| Clinical Research Site | Cincinnati | Ohio | 45215 | Recruiting |
| Clinical Research Site | Edmond | Oklahoma | 73013 | Recruiting |
| Clinical Research Site | Oklahoma City | Oklahoma | 73118 | Recruiting |
| Clinical Research Site | Portland | Oregon | 97210 | Recruiting |
| Clinical Research Site | Memphis | Tennessee | 38119 | Recruiting |
| Clinical Research Site | Dallas | Texas | 75231 | Recruiting |
| Clinical Research Site | Dallas | Texas | 75243 | Recruiting |
| Clinical Research Site | Friendswood | Texas | 77546 | Recruiting |
| Clinical Research Site | San Antonio | Texas | 78229 | Recruiting |
| Clinical Research Site | Wichita Falls | Texas | 76309 | Recruiting |
| Clinical Research Site | Everett | Washington | 98201 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06223880, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 22, 2025 · Synced May 6, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06223880 live on ClinicalTrials.gov.