ClinicalTrials.gov record
Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (Ocular Therapeutix) (Axitinib Implant) in Subjects With Neovascular Age-Related Macular Degeneration
ClinicalTrials.gov ID: NCT06223958
Public ClinicalTrials.gov record NCT06223958. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 9, 2026, 12:18 PM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multicenter, Double-Masked, Randomized, Parallel-Group Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (Axitinib Implant) in Subjects With Neovascular Age-Related Macular Degeneration (nAMD)
Study identification
- NCT ID
- NCT06223958
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Ocular Therapeutix, Inc.
- Industry
- Enrollment
- 344 participants
Conditions and interventions
Conditions
Interventions
- Aflibercept Drug
- OTX-TKI (axitinib implant) Drug
Drug
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 28, 2024
- Primary completion
- Apr 28, 2026
- Completion
- Sep 26, 2027
- Last update posted
- Apr 17, 2025
2024 – 2027
United States locations
- U.S. sites
- 97
- U.S. states
- 28
- U.S. cities
- 84
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Associated Retina Consultants - Gilbert | Gilbert | Arizona | 85297 | — |
| Associated Retina Consultants - Phoenix | Phoenix | Arizona | 85020 | — |
| Retinal Research Institute | Phoenix | Arizona | 85053 | — |
| Retina Macula Institute of Arizona | Scottsdale | Arizona | 85255 | — |
| CA CRC California Retina Consultants | Bakersfield | California | 93103 | — |
| The Retina Partners - Encino | Encino | California | 91436 | — |
| Retina Consultants of Orange County - Fullerton | Fullerton | California | 92835 | — |
| Atlantis Eyecare | Huntington Beach | California | 92647 | — |
| Lakeside Vision Center - Irvine | Irvine | California | 92604 | — |
| Retina-Vitreous Associates Medical Group - Los Angeles | Los Angeles | California | 90017-4886 | — |
| CA RCMG Retinal Consultants Medical Group, Inc. | Modesto | California | 95356 | — |
| Retina Sacramento MSO, LLC | Modesto | California | 95356 | — |
| Kaiser Permanente Division of Research | Oakland | California | 94611 | — |
| CA CRC California Retina Consultants | Oxnard | California | 93103 | — |
| Stanford University School of Medicine, Byers Eye Institute | Palo Alto | California | 94303 | — |
| Doheny Eye Center | Pasadena | California | 91105 | — |
| AzulVision | Pasadena | California | 91107 | — |
| Orange County Retina Medical Group | Santa Ana | California | 92705 | — |
| California Retina Consultants (CRC) - Santa Barbara | Santa Barbara | California | 93103-4211 | — |
| Macula Retina Vitreous Center | Torrance | California | 90505 | — |
| Bay Area Retina Associates, A Medical Group | Walnut Creek | California | 94598 | — |
| Retina Consultants of Southern Colorado - Colorado Springs | Colorado Springs | Colorado | 80909 | — |
| RSC Research, PLLC | Denver | Colorado | 80210 | — |
| Colorado Retina Associates (CRA) - Lakewood | Lakewood | Colorado | 80228 | — |
| Retina Group of New England, PC | Waterford | Connecticut | 06385 | — |
| The Macula Center - Clearwater Office (Suncoast Retina Consultants, LLC) | Clearwater | Florida | 33761 | — |
| Rand Eye Institute | Deerfield Beach | Florida | 33064 | — |
| Speciality Retina Center | Deerfield Beach | Florida | 33064 | — |
| Retina Group of Florida - Fort Lauderdale | Fort Lauderdale | Florida | 33308-1909 | — |
| Florida Retina Institute - Lake Mary | Lake Mary | Florida | 32746-2175 | — |
| Florida Retina Consultants - Lakeland | Lakeland | Florida | 33805 | — |
| South Florida Retina Institute | Miami | Florida | 33145 | — |
| Retina Specialty Institute - Pensacola | Pensacola | Florida | 32503-2030 | — |
| MedEye Associates - Miami | South Miami | Florida | 33143 | — |
| Retina Vitreous Associates of Florida (RVA) - Saint Petersburg | St. Petersburg | Florida | 33711-1141 | — |
| Retina Vitreous Associates of Florida - Tampa | Tampa | Florida | 33607 | — |
| Retina Associates of Florida LLC Tampa MacDill | Tampa | Florida | 33609 | — |
| Southeast Retina Center, P.C. - Augusta | Augusta | Georgia | 30909-6440 | — |
| Illinois Eye and Ear Infirmary at UI Health UIC | Chicago | Illinois | 60612 | — |
| Illinois Retina Associates, S.C. - Lincoln Park | Chicago | Illinois | 60657-7227 | — |
| University Retina and Macula Associates, P.C. | Oak Forest | Illinois | 60452 | — |
| Springfield Clinic | Springfield | Illinois | 62703 | — |
| IN AVRUC Associated Vitreoretinal and Uveitis Consultants | Carmel | Indiana | 46290 | — |
| Retina Partners Midwest | Indianapolis | Indiana | 46290-1166 | — |
| Wolfe Eye Clinic | West Des Moines | Iowa | 50266-7705 | — |
| Maine Eye Center - Marginal Way Campus | Portland | Maine | 04101-2438 | — |
| The Wilmer Eye Institute | Baltimore | Maryland | 21287 | — |
| Mid Atlantic Retina Specialists - Hagerstown | Hagerstown | Maryland | 21740-5846 | — |
| Cumberland Valley Retina Consultants | Hagerstown | Maryland | 21740 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Associated Retinal Consultants P.C. (ARC) - Royal Oak | Royal Oak | Michigan | 48073 | — |
| Retina Consultants of Minnesota | Edina | Minnesota | 55435 | — |
| Mississippi Baptist Medical Center | Jackson | Mississippi | 39202-2064 | — |
| Pepose Vision Institute | Chesterfield | Missouri | 63017 | — |
| Retina Research Institute, LLC | St Louis | Missouri | 63144-1317 | — |
| Sierra Eye Associates | Reno | Nevada | 89502-1605 | — |
| The Retina Center Of New Jersey, LLC - Bloomfield | Bloomfield | New Jersey | 07003 | — |
| Long Island Vitreoretinal Consultants (VRC) - Hauppauge | Hauppauge | New York | 11788 | — |
| Retina-Vitreous Surgeons of Central New York | Liverpool | New York | 13088 | — |
| NY LIVRC Long Island Vitreoretinal Consultants | Shirley | New York | 11967 | — |
| Asheville Eye Associates (AEA) - Retinal Office | Asheville | North Carolina | 28803 | — |
| Duke University Health System - Duke Eye Center Of North Durham | Durham | North Carolina | 27705 | — |
| Retina Associates of Cleveland, Inc. - Beachwood | Beachwood | Ohio | 44122 | — |
| Retina Associates of Cleveland | Cleveland | Ohio | 44130 | — |
| Retina Associates of Cleveland, Inc. - Youngstown | Youngstown | Ohio | 44505 | — |
| Erie Retina Research | Erie | Pennsylvania | 16507 | — |
| Palmetto Retina Center | Aiken | South Carolina | 29802 | — |
| Charleston Neuroscience Institute LLC - Beaufort | Beaufort | South Carolina | 29902 | — |
| SC CNI Retina Consultants of Charleston | Beaufort | South Carolina | 29902 | — |
| Charleston Neuroscience Institute LLC - Charleston | Charleston | South Carolina | 29414 | — |
| Palmetto Retina Center | Florence | South Carolina | 29501 | — |
| Charleston Neuroscience Institute | Ladson | South Carolina | 29456 | — |
| Retina Consultants of Charleston - Mount Pleasant | Mt. Pleasant | South Carolina | 29464 | — |
| Palmetto Retina Center | West Columbia | South Carolina | 29169-2429 | — |
| Black Hills Regional Eye Institute (BHREI) | Rapid City | South Dakota | 57701-7374 | — |
| Vance Thompson Vision | Sioux Falls | South Dakota | 57108 | — |
| Charles Retina Institute PC | Germantown | Tennessee | 38138-2405 | — |
| Tennessee Retina, PC - Nashville - Centennial Professional Plaza Location | Nashville | Tennessee | 37203-1596 | — |
| West Texas Retina Consultants (WTRC) - Abilene (Ophthalmology Specialists of Texas, PA) | Abilene | Texas | 79606 | — |
| Texas Retina Associates (TRA) - Arlington | Arlington | Texas | 76012-2505 | — |
| Retina Consultants of Austin PA (RCA) - Central Austin | Austin | Texas | 78705-1023 | — |
| Austin Retina Associates, PLLC | Austin | Texas | 78705-1169 | — |
| Keystone Research | Austin | Texas | 78731 | — |
| Retina Research Center (RRC) | Austin | Texas | 78750-2302 | — |
| Retina Consultants of Texas Beaumont | Beaumont | Texas | 77707 | — |
| Retina Group, Inc. d/b/a Retina Consultants of America (Retina Consultants of Texas) | Bellaire | Texas | 77401 | — |
| Star Vision Consultants | Burleson | Texas | 76028 | — |
| Texas Retina Center | Houston | Texas | 77030 | — |
| Retina Consultants of Texas - Katy | Katy | Texas | 77494 | — |
| Medical Center Ophthalmology Associates (MCOA) - Northwest Clinic Location | San Antonio | Texas | 78240-1502 | — |
| Retinal Consultants of Texas - San Antonio Medical Center | San Antonio | Texas | 78240 | — |
| TX RCTX Retina Consultants of Texas | San Antonio | Texas | 78240 | — |
| Retina Consultants of Houston | The Woodlands | Texas | 77384 | — |
| Retina Associates of Utah, P.C - Intermountain Medical Center Location | Salt Lake City | Utah | 84107-6767 | — |
| Wagner Macula & Retina Center - Norfolk, VA Office | Norfolk | Virginia | 23502-3933 | — |
| Vistar Eye Center Vision and Surgery Specialists | Roanoke | Virginia | 24019 | — |
| Eye Clinic of Wisconsin | Wausau | Wisconsin | 54403 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 11 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06223958, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 17, 2025 · Synced May 9, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06223958 live on ClinicalTrials.gov.