Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults With PKP2 Mutation-associated ARVC

ClinicalTrials.gov ID: NCT06228924

Public ClinicalTrials.gov record NCT06228924. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 19, 2026, 9:19 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

First-in-Human, Open-Label, Safety, Tolerability, Dose-Finding, Pharmacodynamic and Cardiac Transgene Expression Study of TN-401, a Recombinant Adeno-associated Virus Serotype 9 (AAV9) Containing Plakophilin-2 (PKP2) Transgene, in Adults With PKP2 Mutation-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

Study identification

NCT ID: NCT06228924
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1
Lead sponsor: Tenaya Therapeutics; Industry
Enrollment: 15 participants

Conditions and interventions

Conditions

Arrhythmogenic Right Ventricular Cardiomyopathy

Interventions

TN-401 Genetic

Genetic

Eligibility (public fields only)

Age range: 18 Years to 65 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 25, 2024
Primary completion: Apr 30, 2026
Completion: Sep 30, 2029
Last update posted: Feb 5, 2025

2024 – 2029

United States locations

U.S. sites: 7
U.S. states: 7
U.S. cities: 7

Facility	City	State	ZIP	Site status
University of California San Francisco	San Francisco	California	94143	Recruiting
University of Colorado - Anschutz Medical Campus	Aurora	Colorado	80045	Recruiting
Johns Hopkins University	Baltimore	Maryland	21287	Recruiting
Brigham and Women's Hospital	Boston	Massachusetts	02115	Recruiting
Mayo Clinic	Rochester	Minnesota	55905	Recruiting
NYU Langone Health	New York	New York	10016	Recruiting
Cleveland Clinic	Cleveland	Ohio	44195	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT06228924, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Feb 5, 2025 · Synced May 19, 2026

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The complete protocol, eligibility criteria, and contact information for NCT06228924 live on ClinicalTrials.gov.

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