Phase 2b Trial Comparing HDV-Insulin Lispro to Insulin Lispro in Adults With Type 1 Diabetes Receiving Insulin Degludec
Public ClinicalTrials.gov record NCT06238778. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2b Randomized, Double-blind Trial Comparing HDV-Insulin Lispro Versus Insulin Lispro Alone in Adults With Type 1 Diabetes Receiving Insulin Degludec
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The goal of this study is to see if directing insulin to the liver will improve the low blood sugar that sometimes happens when injecting insulin in Type 1 diabetes patients. Participants will use continuous glucose monitoring to measure the sugar levels in their blood, and work with the doctor to find the best doses. One group of patients will get the liver targeting insulin, and the other group will use insulin they normally use for treating Type 1 diabetes. The participant will be part of the study for up to 32 weeks.
Study identification
- NCT ID
- NCT06238778
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 227 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 79 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 27, 2023
- Primary completion
- Oct 26, 2025
- Completion
- Dec 15, 2025
- Last update posted
- Jul 30, 2026
2023 – 2025
United States locations
- U.S. sites
- 27
- U.S. states
- 12
- U.S. cities
- 26
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Marvel Clinical Research | Huntington Beach | California | 92647 | — |
| Pasadena Clinical Trials | Pasadena | California | 91101 | — |
| Diabetes Research Center | Tustin | California | 92780 | — |
| University of Colorado, Barbara Davis Center | Denver | Colorado | 80045 | — |
| East Coast Institute for Research | Jacksonville | Florida | 32216 | — |
| University of Miami Diabetes Research Institute | Miami | Florida | 33136 | — |
| Metabolic Research Institute | West Palm Beach | Florida | 33401 | — |
| Atlanta Diabetes Associates | Atlanta | Georgia | 30318 | — |
| East Coast Institute for Research | Canton | Georgia | 30114 | — |
| Physicians Research Associates, LLC | Lawrenceville | Georgia | 30046 | — |
| Endocrine Research Solutions, Inc. | Roswell | Georgia | 30076 | — |
| University of Chicago Kovler Diabetes Center | Chicago | Illinois | 60637 | — |
| Endeavor Health | Skokie | Illinois | 60077 | — |
| Indiana Medical Research Institute | Merrillville | Indiana | 46410 | — |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | — |
| Asheville Clinical Research | Asheville | North Carolina | 28803 | — |
| UNC EnDO Clinical Research Unit | Chapel Hill | North Carolina | 27514 | — |
| Physician's East | Greenville | North Carolina | 27834 | — |
| University Hospitals Medical Center | Cleveland | Ohio | 44106 | — |
| Texas Diabetes & Endocrinology | Austin | Texas | 78749 | — |
| Tekton Research, LLC | Irving | Texas | 75039 | — |
| Tekton Research, LLC | McKinney | Texas | 75069 | — |
| Texas Diabetes % Endocrinology | Round Rock | Texas | 78681 | — |
| Clinical Trials of Texas | San Antonio | Texas | 78229 | — |
| Tekton Research, LLC | San Antonio | Texas | 78251 | — |
| Wasatch Clinical Research, LLC 310 | Salt Lake City | Utah | 84107 | — |
| Virginia Endocrinology Research | Chesapeake | Virginia | 23321 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06238778, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 30, 2026 · Synced Sep 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06238778 live on ClinicalTrials.gov.