A Study of RM-718 in Healthy Subjects and Patients With MC4R Pathway Impairment
Public ClinicalTrials.gov record NCT06239116. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Study of RM-718 Weekly Formulation in Healthy Subjects With Obesity and in Patients With Obesity Due to MC4R Impairment
Study identification
- NCT ID
- NCT06239116
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- Rhythm Pharmaceuticals, Inc.
- Industry
- Enrollment
- 150 participants
Conditions and interventions
Conditions
Interventions
- Part A: RM-718 or placebo (matched to specific RM-718 dose cohort) Drug
- Part B: RM-718 or placebo (matched to specific RM-718 dose cohort) Drug
- Part C: RM-718 Drug
- Part D: RM-718 Drug
Drug
Eligibility (public fields only)
- Age range
- 12 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 4, 2024
- Primary completion
- Oct 31, 2027
- Completion
- Oct 31, 2028
- Last update posted
- Dec 21, 2025
2024 – 2028
United States locations
- U.S. sites
- 7
- U.S. states
- 6
- U.S. cities
- 6
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UAB Pediatric Endocrinology (Part C and Part D) | Birmingham | Alabama | 35233 | Recruiting |
| Ann and Robert H. Lurie Children's Hospital of Chicago (Part C and Part D) | Chicago | Illinois | 60611 | Recruiting |
| Boston Children's Hospital (Part C only) | Boston | Massachusetts | 021115 | Recruiting |
| Brigham and Women's Hospital (Part C and Part D) | Boston | Massachusetts | 02115 | Recruiting |
| Vanderbilt University Medical Center (Part C only) | Nashville | Tennessee | 37232 | Recruiting |
| Worldwide Clinical Trials (Part A and Part B) | San Antonio | Texas | 78217 | Completed |
| University of Utah Pediatric Endocrine Clinic (Part C and Part D) | Salt Lake City | Utah | 84112 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06239116, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 21, 2025 · Synced May 18, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06239116 live on ClinicalTrials.gov.