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Recruiting Phase 3 Interventional

Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation

ClinicalTrials.gov ID: NCT06252649

Public ClinicalTrials.gov record NCT06252649. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 5, 2026, 4:56 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase 3 Multicenter, Randomized, Open-label, Active-controlled Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb for Treatment-naïve Subjects With Metastatic Colorectal Cancer With KRAS p.G12C Mutation (CodeBreaK 301)

Study identification

NCT ID
NCT06252649
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Amgen
Industry
Enrollment
450 participants

Conditions and interventions

Interventions

  • Bevacizumab-awwb Drug
  • FOLFIRI Regimen Drug
  • Panitumumab Drug
  • Sotorasib Drug

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jul 16, 2024
Primary completion
Jan 30, 2028
Completion
Aug 30, 2031
Last update posted
Apr 23, 2026

2024 – 2031

United States locations

U.S. sites
26
U.S. states
14
U.S. cities
24
Facility City State ZIP Site status
Ironwood Cancer and Research Centers Scottsdale Chandler Arizona 85224 Recruiting
Providence Saint Jude Medical Center Fullerton California 92835 Recruiting
City of Hope National Medical Center Long Beach California 90813 Recruiting
Cancer and Blood Research Center, LLC Los Alamitos California 90720 Recruiting
California Research Institute Los Angeles California 90027 Recruiting
Norwalk Hospital Norwalk Connecticut 06856 Terminated
Cancer Specialists of North Florida - Southpoint Jacksonville Florida 32256 Recruiting
D and H Cancer Research Center Margate Florida 33063 Recruiting
Mid Florida Hematology and Oncology Centers PA Orange City Florida 32763 Terminated
Boca Raton Clinical Research Medical Center Inc Plantation Florida 33322 Terminated
Georgia Cancer Specialists Atlanta Georgia 30342 Recruiting
Insight Research Institute Chicago Illinois 60616 Recruiting
Hope and Healing Cancer Services Hinsdale Illinois 60521 Terminated
Orchard Healthcare Research Inc Skokie Illinois 60076 Terminated
Pikeville Medical Center Pikeville Kentucky 41501 Recruiting
Henry Ford Health System Detroit Michigan 48202 Recruiting
Cancer and Hematology Centers of Western Michigan Grand Rapids Michigan 49503 Recruiting
Saint Louis Cancer Care West County Bridgeton Missouri 63044 Recruiting
Minniti Center for Medical Oncology and Hematology Mickleton New Jersey 08056 Recruiting
Duke Cancer Center Durham North Carolina 27710 Recruiting
FirstHealth Cancer Center Pinehurst North Carolina 28374 Recruiting
Thomas Jefferson University Philadelphia Pennsylvania 19107 Recruiting
Carolina Blood and Cancer Care Rock Hill South Carolina 29732 Completed
Tennessee Oncology PLLC - Chattanooga Nashville Tennessee 37203 Recruiting
Tennessee Oncology, PLLC Nashville Tennessee 37203 Recruiting
Vanderbilt University Medical Center Nashville Tennessee 37232 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 260 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06252649, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Apr 23, 2026 · Synced May 5, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06252649 live on ClinicalTrials.gov.

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