A First-in-human Study of PARP1 Selective Inhibitor, IMP1734, in Participants With Advanced Solid Tumors
Public ClinicalTrials.gov record NCT06253130. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A First-in-human, Phase 1/2, Open-label, Multi-center, Dose-escalation, Dose-optimization, and Dose-expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Anti-tumor Activity of PARP1 Selective Inhibitor, IMP1734, as Monotherapy in Patients With Advanced Solid Tumors
Study identification
- NCT ID
- NCT06253130
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- Eikon Therapeutics
- Industry
- Enrollment
- 156 participants
Conditions and interventions
Conditions
Interventions
- IMP1734 Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 89 Years
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 10, 2023
- Primary completion
- May 31, 2027
- Completion
- Nov 30, 2027
- Last update posted
- Mar 22, 2026
2023 – 2027
United States locations
- U.S. sites
- 23
- U.S. states
- 16
- U.S. cities
- 21
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| The University of Arizona Cancer Center | Tucson | Arizona | 85719 | Recruiting |
| University of Arkansas Winthrop P. Rockefeller Cancer Institute | Little Rock | Arkansas | 72205 | Recruiting |
| Hoag Health Center Irvine | Irvine | California | 92618 | Recruiting |
| University California Irvine | Irvine | California | 92868 | Withdrawn |
| Sharp Memorial Hospital | San Diego | California | 92123 | Withdrawn |
| University of California San Francisco (UCSF) | San Francisco | California | 94158 | Withdrawn |
| Sarah Cannon Research Institute Health One | Denver | Colorado | 80218 | Recruiting |
| Smilow Cancer Hospital at Yale New Haven | New Haven | Connecticut | 06511 | Recruiting |
| Advent Health Research Institute | Celebration | Florida | 34747 | Recruiting |
| Sylvester Comprehensive Cancer Center | Miami | Florida | 33136 | Recruiting |
| University of Michigan Rogel Cancer Center | Ann Arbor | Michigan | 48109 | Recruiting |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | Recruiting |
| Henry Ford Health | Detroit | Michigan | 48202 | Recruiting |
| University of Minnesota-Clinical Research Unit | Minneapolis | Minnesota | 55455 | Recruiting |
| Washington University - Siteman Cancer Center | St Louis | Missouri | 63110 | Withdrawn |
| John Theurer Cancer Center | Hackensack | New Jersey | 07601 | Withdrawn |
| Cayuga Medical Center | Ithaca | New York | 14850 | Withdrawn |
| Lifespan Cancer Institute | Providence | Rhode Island | 02903 | Recruiting |
| Medical University of South Carolina (MUSC) - Hollings CC | Charleston | South Carolina | 29425 | Recruiting |
| West Cancer Center & Research Institute | Germantown | Tennessee | 38138 | Recruiting |
| Sarah Cannon Research Institue Oncology | Nashville | Tennessee | 37203 | Recruiting |
| START - South Texas Accelerated Research Therapeutics | San Antonio | Texas | 78229 | Withdrawn |
| START Mountain Region | West Valley City | Utah | 84119 | Withdrawn |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 30 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06253130, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 22, 2026 · Synced Apr 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06253130 live on ClinicalTrials.gov.