A Phase 1/1b Study of IAM1363 in HER2 Cancers
Public ClinicalTrials.gov record NCT06253871. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1/1b Study of IAM1363 in Participants With Advanced Cancers Harboring HER2 Alterations
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 1/1b open-label, multi-center dose escalation and dose optimization study designed to evaluate the safety and preliminary efficacy of IAM1363 in participants with advanced cancers that harbor HER2 alterations.
Study identification
- NCT ID
- NCT06253871
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1
- Enrollment
- 383 participants
Conditions and interventions
Conditions
- HER2 Mutation-Related Tumors
- HER2
- HER2-positive Breast Cancer
- HER2 + Breast Cancer
- Brain Metastases From Solid Tumors
- Brain Metastases From HER2 and Breast Cancer
- CNS Metastases
- HER2-Positive Solid Tumors
- NSCLC (Non-small Cell Lung Cancer)
- HER2-positive Bladder Cancer
- HER2-positive Colorectal Cancer
- HER2 + Gastric Cancer
- HER2-positive Gastroesophageal Cancer
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 25, 2024 (Actual)
- Primary completion
- Dec 2027 (Estimated)
- Completion
- Dec 2028 (Estimated)
- Last update posted
- Sep 9, 2026
2024 – 2028
United States locations
- U.S. sites
- 29
- U.S. states
- 19
- U.S. cities
- 26
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UCSD Moores Cancer Center | La Jolla | California | 92093 | Recruiting |
| USC Norris Comprehensive Cancer Center | Los Angeles | California | 90089 | Recruiting |
| University of Colorado Cancer Center | Aurora | Colorado | 80045 | Recruiting |
| University of Miami | Miami | Florida | 33136 | Recruiting |
| Comprehensive Hematology Oncology | St. Petersburg | Florida | 33709 | Recruiting |
| University of Chicago | Chicago | Illinois | 60637 | Recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Recruiting |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215 | Recruiting |
| University of Michigan | Ann Arbor | Michigan | 48109 | Recruiting |
| Henry Ford Cancer Institute | Detroit | Michigan | 48202 | Recruiting |
| START - Midwest Cancer Research Center | Grand Rapids | Michigan | 49546 | Recruiting |
| Saint Luke's Cancer Institute | Kansas City | Missouri | 64111 | Recruiting |
| Washington University School of Medicine | St Louis | Missouri | 63110 | Recruiting |
| Dartmouth Hitchcock Medical | Lebanon | New Hampshire | 03756 | Recruiting |
| Rutgers Cancer Institute | New Brunswick | New Jersey | 08901 | Recruiting |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | Recruiting |
| Duke Cancer Institute | Durham | North Carolina | 27710 | Recruiting |
| University Hospital Cleveland Medical Center | Cleveland | Ohio | 44106 | Recruiting |
| Cleveland Clinic | Cleveland | Ohio | 44195 | Recruiting |
| OU Health Stephenson Cancer Center | Oklahoma City | Oklahoma | 73104 | Recruiting |
| Providence Cancer Institute | Portland | Oregon | 97213 | Recruiting |
| SCRI Oncology Partners | Nashville | Tennessee | 37203 | Recruiting |
| Vanderbilt Ingram Cancer Center | Nashville | Tennessee | 37232 | Recruiting |
| NEXT Oncology - Austin | Austin | Texas | 78758 | Recruiting |
| Mary Crowley Cancer Research | Dallas | Texas | 75230 | Recruiting |
| MD Anderson Cancer Center - University of Texas | Houston | Texas | 77030 | Recruiting |
| START Mountain Region | West Valley City | Utah | 84119 | Recruiting |
| NEXT Oncology - Virginia Cancer Specialists | Fairfax | Virginia | 22031 | Recruiting |
| Fred Hutchinson Cancer Center | Seattle | Washington | 98109 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 24 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06253871, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 9, 2026 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06253871 live on ClinicalTrials.gov.