Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)
Public ClinicalTrials.gov record NCT06260722. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Multicenter, Open-label Study to Investigate the Efficacy and Safety of Retatrutide Once Weekly Compared With Semaglutide Once Weekly in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to investigate the efficacy and safety of retatrutide compared with semaglutide in participants with Type 2 Diabetes and inadequate glycemic control with metformin with or without sodium-glucose cotransporter-2 inhibitor (SGLT2i). The study will last about 26 months and may include up to 24 visits.
Study identification
- NCT ID
- NCT06260722
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,250 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 21, 2024 (Actual)
- Primary completion
- Aug 27, 2026 (Actual)
- Completion
- Feb 2027 (Estimated)
- Last update posted
- Sep 28, 2026
2024 – 2027
United States locations
- U.S. sites
- 38
- U.S. states
- 22
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama - Department of Nutrition Sciences | Birmingham | Alabama | 35294 | — |
| Neighborhood Healthcare Institute of Health | Escondido | California | 92025 | — |
| Long Beach Research Institute | Long Beach | California | 90805 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| Rancho Cucamonga Clinical Research | Rancho Cucamonga | California | 91730 | — |
| University of Colorado Anschutz Medical Campus | Aurora | Colorado | 80045 | — |
| Arrow Clinical Trials | Daytona Beach | Florida | 32117 | — |
| New Age Medical Research Corporation | Miami | Florida | 33186 | — |
| South Broward Research | Miramar | Florida | 33027 | — |
| Clinical Research of Central Florida | Winter Haven | Florida | 33880 | — |
| Herman Clinical Research | Suwanee | Georgia | 30024 | — |
| North Georgia Clinical Research | Woodstock | Georgia | 30189 | — |
| Pacific Diabetes & Endocrine Center | Honolulu | Hawaii | 96817 | — |
| Rocky Mountain Clinical Research | Idaho Falls | Idaho | 83404 | — |
| Deaconess Clinic - Gateway Health Center | Newburgh | Indiana | 47630 | — |
| IMA Clinical Research Monroe - Armand | Monroe | Louisiana | 71201 | — |
| MedStar Health Research Institute (MedStar Physician Based Research Network) | Hyattsville | Maryland | 20782 | — |
| Brigham and Women's Hospital Diabetes Program | Boston | Massachusetts | 02115 | — |
| NECCR PrimaCare Research | Fall River | Massachusetts | 02721 | — |
| Arcturus Healthcare , PLC, Troy Internal Medicine Research Division | Troy | Michigan | 48098 | — |
| Palm Research Center Tenaya | Las Vegas | Nevada | 89128 | — |
| Palm Research Center Sunset | Las Vegas | Nevada | 89148 | — |
| NYC Research INC | Long Island City | New York | 11106 | — |
| Medication Management | Greensboro | North Carolina | 27405 | — |
| Remington Davis Clinical Research | Columbus | Ohio | 43215 | — |
| Alliance for Multispecialty Research, LLC | Norman | Oklahoma | 73069 | — |
| Central States Research | Tulsa | Oklahoma | 74136 | — |
| The Corvallis Clinic, P.C. | Corvallis | Oregon | 97330 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Velocity Clinical Research, Dallas | Dallas | Texas | 75230 | — |
| Valley Institute of Research - Fort Worth | Fort Worth | Texas | 76164 | — |
| Juno Research | Houston | Texas | 77040 | — |
| Southern Endocrinology Associates | Mesquite | Texas | 75149 | — |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | — |
| Texas Valley Clinical Research | Weslaco | Texas | 78596 | — |
| Medrasa Clinical Research | Wylie | Texas | 75098 | — |
| Central Washington Health Services Association d/b/a Confluence Health | Wenatchee | Washington | 98801 | — |
| IMA Clinical Research West Virginia | Morgantown | West Virginia | 26505 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 39 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06260722, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 28, 2026 · Synced Oct 24, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06260722 live on ClinicalTrials.gov.