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Recruiting Phase 3 Interventional

VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]

ClinicalTrials.gov ID: NCT06264180

Public ClinicalTrials.gov record NCT06264180. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 22, 2026, 8:59 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Randomized, Ph3 Clinical Study Comparing Vusolimogene Oderparepvec in Combination With Nivolumab Vs Treatment of Physician's Choice in Patients With Advanced Melanoma That Progressed on Anti-PD-1 and Anti-CTLA-4 Containing Treatment [IGNYTE-3]

Study identification

NCT ID
NCT06264180
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Replimune, Inc.
Industry
Enrollment
400 participants

Conditions and interventions

Interventions

  • Nivolumab Biological
  • Nivolumab + Relatlimab Biological
  • Pembrolizumab Biological
  • Single-agent chemotherapy Drug
  • Vusolimogene Oderparepvec Biological

Biological · Drug

Eligibility (public fields only)

Age range
12 Years and older
Sex
All
Healthy volunteers
Not listed

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jul 10, 2024
Primary completion
Dec 31, 2028
Completion
Aug 30, 2034
Last update posted
Mar 12, 2026

2024 – 2034

United States locations

U.S. sites
49
U.S. states
24
U.S. cities
44
Facility City State ZIP Site status
Banner MD Anderson Cancer Center Gilbert Arizona 85234 Recruiting
UC San Diego Moores Cancer Center La Jolla California 92037 Recruiting
The Angeles Clinic and Research Institute Los Angeles California 90025 Recruiting
USC Norris Comprehensive Cancer Center Los Angeles California 90033 Recruiting
UCLA Department of Medicine - Hematology/Oncology Los Angeles California 90095 Recruiting
UC Irvine Health, Chao Family Comprehensive Cancer Center Orange California 92868 Recruiting
Stanford Cancer Institute Palo Alto California 94304 Recruiting
Sutter Medical Group Sacramento California 95816 Recruiting
San Francisco Oncology Associates San Francisco California 94115 Recruiting
UCSF Helen Diller Family Comprehensive Cancer Center San Francisco California 94143 Recruiting
University of Colorado Hospital - Anschutz Cancer Pavilion Aurora Colorado 80045 Recruiting
The Melanoma and Skin Cancer Institute Englewood Colorado 80113 Recruiting
MedStar Washington Hospital Center Washington D.C. District of Columbia 20010 Recruiting
Memorial Cancer Institute at Memorial Regional Hospital Hollywood Florida 33021 Recruiting
Moffitt Cancer Center Tampa Florida 33612 Recruiting
Winship Cancer Institute, Emory University Atlanta Georgia 30322 Recruiting
Northwestern Memorial Hospital Chicago Illinois 60611 Recruiting
Advocate Lutheran General Hospital Park Ridge Illinois 60068 Withdrawn
University of Iowa Iowa City Iowa 52242 Recruiting
University of Kansas Cancer Center Westwood Kansas 66205 Recruiting
University of Louisville Brown Cancer Center Louisville Kentucky 40202 Recruiting
Henry Ford Cancer - Detroit (Brigitte Harris Cancer Pavilion) Detroit Michigan 48202 Recruiting
Corewell Health Grand Rapids Michigan 49503 Recruiting
University of Minnesota Minneapolis Minnesota 55455 Recruiting
Dartmouth Hitchcock Cancer Center Lebanon New Hampshire 03756 Recruiting
MD Anderson Cancer Center at Cooper Camden New Jersey 08103 Recruiting
Hackensack University Medical Center Hackensack New Jersey 07601 Recruiting
Morristown Medical Center - Atlantic Health System Morristown New Jersey 07960 Recruiting
Roswell Park Cancer Institute Buffalo New York 14263 Recruiting
Northwell Health, R.J. Zuckerberg Cancer Center Lake Success New York 11042 Recruiting
Stony Brook University Cancer Center Stony Brook New York 11794 Recruiting
Montefiore Medical Center The Bronx New York 10461 Recruiting
University of North Carolina at Chapel Hill Chapel Hill North Carolina 27514 Recruiting
Duke Cancer Center Durham North Carolina 27710 Recruiting
The Ohio State University- Martha Morehouse Tower Columbus Ohio 43210 Recruiting
Thomas Jefferson University Philadelphia Pennsylvania 19107 Recruiting
Fox Chase Cancer Center Philadelphia Pennsylvania 19111 Recruiting
UPMC Pittsburgh Pennsylvania 15232 Recruiting
Rhode Island Hospital Providence Rhode Island 02903 Recruiting
West Cancer Center and Research Institute Germantown Tennessee 38138 Recruiting
University of Tennessee Knoxville Tennessee 37920 Recruiting
Texas Oncology Dallas Texas 75246 Recruiting
University of Texas Southwestern Medical Center Dallas Texas 75390 Recruiting
The University of Texas MD Anderson Cancer Center Houston Texas 77030 Recruiting
Intermountain Health Murray Utah 84107 Recruiting
Huntsman Cancer Institute Salt Lake City Utah 84112 Recruiting
St. George Regional Hospital St. George Utah 84790 Recruiting
University of Vermont Medical Center Burlington Vermont 05401 Recruiting
West Virginia University Morgantown West Virginia 26506 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 24 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06264180, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Mar 12, 2026 · Synced Apr 22, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06264180 live on ClinicalTrials.gov.

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