ClinicalTrials.gov record
Study to Evaluate the Efficacy, Safety, and Tolerability of an Anti-MTBR Tau Monoclonal Antibody (BMS-986446) in Participants With Early Alzheimer's Disease
ClinicalTrials.gov ID: NCT06268886
Open the official record
This page only displays public information reproduced from the official ClinicalTrials.gov record NCT06268886. It adds no medical advice, opinions, or eligibility judgments. The official record remains the source of truth for eligibility criteria, enrollment, and contact information.
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Official title
A Randomized, Double-blind, Placebo-controlled, Global Proof-of-concept Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986446, an Anti-MTBR Tau Monoclonal Antibody, in Participants With Early Alzheimer's Disease (TargetTau-1)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to assess the effectiveness, safety, and tolerability of BMS-986446 an Anti-MTBR Tau Monoclonal Antibody in participants with Early Alzheimer's Disease.
Study identification
- NCT ID
- NCT06268886
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 310 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 20, 2024 (Actual)
- Primary completion
- Dec 17, 2026 (Estimated)
- Completion
- Apr 17, 2028 (Estimated)
- Last update posted
- Nov 2, 2026
2024 – 2028
United States locations
- U.S. sites
- 119
- U.S. states
- 17
- U.S. cities
- 81
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Local Institution - 0068 | Chandler | Arizona | 85226-3732 | — |
| Local Institution - 0102 | Gilbert | Arizona | 85297-0441 | — |
| Local Institution - 0019 | Phoenix | Arizona | 85004 | — |
| Local Institution - 0018 | Scottsdale | Arizona | 85253 | — |
| Local Institution - 0026 | Scottsdale | Arizona | 85258-4595 | — |
| Local Institution - 0077 | Tucson | Arizona | 85718-6522 | — |
| Local Institution - 0038 | Tucson | Arizona | 85718-6632 | — |
| Local Institution - 0164 | Encino | California | 91316-1511 | — |
| Local Institution - 0139 | Fullerton | California | 92835-1040 | — |
| Local Institution - 0191 | Irvine | California | 92614-9403 | — |
| Local Institution - 0234 | Long Beach | California | 90804-2128 | — |
| Local Institution - 0142 | Los Alamitos | California | 90720-3589 | — |
| Local Institution - 0037 | Napa | California | 94558-2415 | — |
| Local Institution - 0209 | Sacramento | California | 95816 | — |
| Local Institution - 0052 | San Francisco | California | 94143-2350 | — |
| Local Institution - 0137 | Santa Ana | California | 92705-8675 | — |
| Local Institution - 0046 | Sherman Oaks | California | 91403-2131 | — |
| Local Institution - 0106 | Danbury | Connecticut | 06810-4088 | — |
| Local Institution - 0148 | New Haven | Connecticut | 06510 | — |
| Local Institution - 0056 | New Haven | Connecticut | 06511-5249 | — |
| Local Institution - 0153 | Stamford | Connecticut | 06905-1206 | — |
| Local Institution - 0022 | Altamonte Springs | Florida | 32714-2436 | — |
| Local Institution - 0048 | Atlantis | Florida | 33462-6631 | — |
| Local Institution - 0228 | Boca Raton | Florida | 33428-2236 | — |
| Local Institution - 0250 | Boca Raton | Florida | 33487-3626 | — |
| Local Institution - 0224 | Bradenton | Florida | 34205 | — |
| Local Institution - 0020 | Clermont | Florida | 34711-5933 | — |
| Local Institution - 0009 | Daytona Beach | Florida | 32117-5532 | — |
| Local Institution - 0213 | Fort Myers | Florida | 33912-4302 | — |
| Local Institution - 0059 | Greenacres City | Florida | 33467 | — |
| Local Institution - 0207 | Hialeah | Florida | 33012-4170 | — |
| Local Institution - 0212 | Hialeah | Florida | 33015-5110 | — |
| Local Institution - 0198 | Hialeah | Florida | 33016-1814 | — |
| Local Institution - 0151 | Lady Lake | Florida | 32159 | — |
| Local Institution - 0146 | Lakeland | Florida | 33805-2208 | — |
| Local Institution - 0192 | Maitland | Florida | 32751-3320 | — |
| Local Institution - 0143 | Maitland | Florida | 32751 | — |
| Local Institution - 0027 | Merritt Island | Florida | 32952-3616 | — |
| Local Institution - 0203 | Miami | Florida | 33032 | — |
| Local Institution - 0058 | Miami | Florida | 33122-1335 | — |
| Local Institution - 0034 | Miami | Florida | 33125-4719 | — |
| Local Institution - 0211 | Miami | Florida | 33126 | — |
| Local Institution - 0195 | Miami | Florida | 33133-4231 | — |
| Local Institution - 0014 | Miami | Florida | 33135-2957 | — |
| Local Institution - 0005 | Miami | Florida | 33135-2968 | — |
| Local Institution - 0208 | Miami | Florida | 33135-4759 | — |
| Local Institution - 0013 | Miami | Florida | 33135 | — |
| Local Institution - 0008 | Miami | Florida | 33137-2706 | — |
| Local Institution - 0199 | Miami | Florida | 33144 | — |
| Local Institution - 0206 | Miami | Florida | 33155-4630 | — |
| Local Institution - 0176 | Miami | Florida | 33155-6540 | — |
| Local Institution - 0071 | Miami | Florida | 33166-2710 | — |
| Local Institution - 0156 | Miami | Florida | 33175-3598 | — |
| Local Institution - 0249 | Miami | Florida | 33176-2151 | — |
| Local Institution - 0039 | Miami | Florida | 33176-7947 | — |
| Local Institution - 0225 | Miami | Florida | 33176 | — |
| Local Institution - 0197 | Miami Springs | Florida | 33166-7225 | — |
| Local Institution - 0217 | Naples | Florida | 34105 | — |
| Local Institution - 0017 | New Port Richey | Florida | 34652-4020 | — |
| Local Institution - 0144 | Ocala | Florida | 34471 | — |
| Local Institution - 0202 | Orlando | Florida | 32806-8521 | — |
| Local Institution - 0219 | Orlando | Florida | 32807 | — |
| Local Institution - 0035 | Orlando | Florida | 32819-8031 | — |
| Local Institution - 0238 | Orlando | Florida | 32832 | — |
| Local Institution - 0210 | Port Orange | Florida | 32127-5170 | — |
| Local Institution - 0204 | Sarasota | Florida | 34239-3228 | — |
| Local Institution - 0012 | Stuart | Florida | 34997-5765 | — |
| Local Institution - 0136 | Stuart | Florida | 34997-6405 | — |
| Local Institution - 0200 | Tampa | Florida | 33607-6210 | — |
| Local Institution - 0080 | Tampa | Florida | 33607-6616 | — |
| Local Institution - 0087 | Tampa | Florida | 33609-4049 | — |
| Local Institution - 0042 | Tampa | Florida | 33613-4808 | — |
| Local Institution - 0194 | Viera | Florida | 32940-7948 | — |
| Local Institution - 0011 | Wellington | Florida | 33414-9320 | — |
| Local Institution - 0223 | West Palm Beach | Florida | 33407-3234 | — |
| Local Institution - 0149 | West Palm Beach | Florida | 33409-6611 | — |
| Local Institution - 0029 | Windermere | Florida | 34786-8919 | — |
| Local Institution - 0101 | Winter Park | Florida | 32789-1848 | — |
| Local Institution - 0154 | Winter Park | Florida | 32792 | — |
| Local Institution - 0105 | Columbus | Georgia | 31909-1692 | — |
| Local Institution - 0236 | Chicago | Illinois | 60611-2818 | — |
| Local Institution - 0021 | Chicago | Illinois | 60640-2831 | — |
| Local Institution - 0161 | Elk Grove Village | Illinois | 60007-3362 | — |
| Local Institution - 0003 | Gurnee | Illinois | 60031 | — |
| Local Institution - 0145 | Park Ridge | Illinois | 60068 | — |
| Local Institution - 0081 | Springfield | Illinois | 62702-4968 | — |
| Local Institution - 0235 | Boston | Massachusetts | 02116 | — |
| Local Institution - 0025 | Boston | Massachusetts | 02131-2515 | — |
| Local Institution - 0015 | Braintree | Massachusetts | 02184 | — |
| Local Institution - 0174 | Foxborough | Massachusetts | 02035-1309 | — |
| Local Institution - 0118 | Methuen | Massachusetts | 01844-5864 | — |
| Local Institution - 0040 | Newton | Massachusetts | 02459-3328 | — |
| Local Institution - 0120 | Plymouth | Massachusetts | 02360-7223 | — |
| Local Institution - 0045 | Watertown | Massachusetts | 02472-4153 | — |
| Local Institution - 0119 | Portsmouth | New Hampshire | 03801-6822 | — |
| Local Institution - 0031 | Princeton | New Jersey | 08540-2859 | — |
| Local Institution - 0062 | Toms River | New Jersey | 08755-5043 | — |
| Local Institution - 0060 | Albany | New York | 12208-3464 | — |
| Local Institution - 0157 | Amherst | New York | 14226-1727 | — |
| Local Institution - 0061 | Manhasset | New York | 11030-3816 | — |
| Local Institution - 0205 | New York | New York | 10029-5611 | — |
| Local Institution - 0214 | New York | New York | 10029-5611 | — |
| Local Institution - 0104 | New York | New York | 10029-6504 | — |
| Local Institution - 0133 | New York | New York | 10032-3726 | — |
| Local Institution - 0043 | Matthews | North Carolina | 28105-8336 | — |
| Local Institution - 0215 | Dayton | Ohio | 45459-4296 | — |
| Local Institution - 0155 | Independence | Ohio | 44131 | — |
| Local Institution - 0023 | Plymouth Meeting | Pennsylvania | 19462-7401 | — |
| Local Institution - 0024 | East Providence | Rhode Island | 02914 | — |
| Local Institution - 0163 | Providence | Rhode Island | 02906-4800 | — |
| Local Institution - 0132 | Cordova | Tennessee | 38018-4254 | — |
| Local Institution - 0140 | Franklin | Tennessee | 37067-5922 | — |
| Local Institution - 0222 | Nashville | Tennessee | 37212 | — |
| Local Institution - 0069 | Austin | Texas | 78757-8046 | — |
| Local Institution - 0033 | Beaumont | Texas | 77702 | — |
| Local Institution - 0051 | Dallas | Texas | 75231-4316 | — |
| Local Institution - 0016 | Houston | Texas | 77074-1812 | — |
| Local Institution - 0196 | Fairfax | Virginia | 22031-5216 | — |
| Local Institution - 0168 | Richmond | Virginia | 23294 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 57 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06268886, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 2, 2026 · Synced Nov 15, 2026
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