A Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Non-cystic Fibrosis Bronchiectasis
Public ClinicalTrials.gov record NCT06280391. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Placebo-controlled, Parallel-group, Proof-of-Concept (PoC) Study to Assess the Efficacy, Safety and Tolerability of Itepekimab, in Participants With Non-cystic Fibrosis Bronchiectasis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
ACT18018 is a multinational, randomized, double-blind, placebo-controlled, parallel-group, Phase 2 study with 3 treatment groups. The purpose of this study was to evaluate efficacy, safety and tolerability with 2 dosing regimens of itepekimab compared with placebo in male and/or female participants with NCFB aged 18 years of age up to 85 years of age (inclusive). Study details include: * The study duration (screening, 24-52-week treatment, 20-week safety follow-up) was up to 47-77 weeks * The treatment duration was up to 24-52 weeks * The follow-up duration was 20 weeks * Site/phone visits were at a monthly interval
Study identification
- NCT ID
- NCT06280391
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 314 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 20, 2024 (Actual)
- Primary completion
- Sep 16, 2025 (Actual)
- Completion
- Feb 2, 2026 (Actual)
- Last update posted
- Oct 7, 2026
2024 – 2026
United States locations
- U.S. sites
- 23
- U.S. states
- 14
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pulmonary Associates - Phoenix - East McDowell Road- Site Number : 8400012 | Phoenix | Arizona | 85006 | — |
| Southern California Institute for Respiratory Diseases- Site Number : 8400002 | Los Angeles | California | 90048 | — |
| Allianz Research Institute- Site Number : 8400013 | Westminster | California | 92683 | — |
| Allianz Research Institute CO- Site Number : 8400038 | Aurora | Colorado | 80014 | — |
| University of Connecticut Health Center- Site Number : 8400020 | Farmington | Connecticut | 06032 | — |
| Yale New Haven Hospital- Site Number : 8400065 | New Haven | Connecticut | 06510 | — |
| Advanced Pulmonary Research Institute- Site Number : 8400007 | Loxahatchee Groves | Florida | 33470 | — |
| High Quality Research- Site Number : 8400047 | Miami | Florida | 33184 | — |
| Avanza Medical Research Center- Site Number : 8400018 | Pensacola | Florida | 32503 | — |
| Private Practice - Dr. Frank Hull - Plantation- Site Number : 8400010 | Plantation | Florida | 33324 | — |
| Northwestern Memorial Hospital- Site Number : 8400043 | Chicago | Illinois | 60611 | — |
| University of Kansas Medical Center- Site Number : 8400045 | Kansas City | Kansas | 66160 | — |
| University of Michigan Health System - Ann Arbor- Site Number : 8400055 | Ann Arbor | Michigan | 48109 | — |
| Pulmonary and Medicine Associates- Site Number : 8400057 | Warren | Michigan | 48088 | — |
| Washington University- Site Number : 8400046 | St Louis | Missouri | 63110 | — |
| NYU Langone Medical Center- Site Number : 8400032 | New York | New York | 10016 | — |
| Southeastern Research Center- Site Number : 8400008 | Winston-Salem | North Carolina | 27103 | — |
| Clinical Research Associates of Central PA - Dubois- Site Number : 8400005 | DuBois | Pennsylvania | 15801 | — |
| Penn Medicine: University of Pennsylvania Health System- Site Number : 8400039 | Philadelphia | Pennsylvania | 19104 | — |
| Medical University of South Carolina - Charleston - Jonathan Lucas Street- Site Number : 8400027 | Charleston | South Carolina | 29425 | — |
| Metroplex Pulmonary and Sleep Center- Site Number : 8400014 | McKinney | Texas | 75069 | — |
| Pioneer Research Solutions, Inc.- Site Number : 8400048 | Sugar Land | Texas | 77479 | — |
| The University of Texas Health Center at Tyler- Site Number : 8400053 | Tyler | Texas | 75708 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 94 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06280391, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 7, 2026 · Synced Oct 26, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06280391 live on ClinicalTrials.gov.