A Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Non-cystic Fibrosis Bronchiectasis
Public ClinicalTrials.gov record NCT06280391. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Placebo-controlled, Parallel-group, Proof-of-Concept (PoC) Study to Assess the Efficacy, Safety and Tolerability of Itepekimab, in Participants With Non-cystic Fibrosis Bronchiectasis
Study identification
- NCT ID
- NCT06280391
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Sanofi
- Industry
- Enrollment
- 312 participants
Conditions and interventions
Conditions
Interventions
- Itepekimab (SAR440340) Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 19, 2024
- Primary completion
- Sep 15, 2025
- Completion
- Feb 1, 2026
- Last update posted
- Feb 11, 2026
2024 – 2026
United States locations
- U.S. sites
- 32
- U.S. states
- 15
- U.S. cities
- 29
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham- Site Number : 8400040 | Birmingham | Alabama | 35233 | — |
| Pulmonary Associates - Phoenix - East McDowell Road- Site Number : 8400012 | Phoenix | Arizona | 85006 | — |
| Southern California Institute for Respiratory Diseases- Site Number : 8400002 | Los Angeles | California | 90048 | — |
| Institute Healthcare Assessment- Site Number : 8400037 | San Diego | California | 92120 | — |
| Allianz Research Institute- Site Number : 8400013 | Westminster | California | 92683 | — |
| Allianz Research Institute CO- Site Number : 8400038 | Aurora | Colorado | 80014 | — |
| University of Connecticut Health Center- Site Number : 8400020 | Farmington | Connecticut | 06032 | — |
| Yale New Haven Hospital- Site Number : 8400065 | New Haven | Connecticut | 06510 | — |
| Advanced Pulmonary Research Institute- Site Number : 8400007 | Loxahatchee Groves | Florida | 33470 | — |
| Clever Medical Research- Site Number : 8400001 | Miami | Florida | 33126 | — |
| My Community Research Center- Site Number : 8400023 | Miami | Florida | 33155 | — |
| High Quality Research- Site Number : 8400047 | Miami | Florida | 33184 | — |
| Destiny Research Center- Site Number : 8400049 | Palmetto Bay | Florida | 33157 | — |
| Avanza Medical Research Center- Site Number : 8400018 | Pensacola | Florida | 32503 | — |
| Private Practice - Dr. Frank Hull - Plantation- Site Number : 8400010 | Plantation | Florida | 33324 | — |
| Northwestern Memorial Hospital- Site Number : 8400043 | Chicago | Illinois | 60611 | — |
| University of Kansas Medical Center- Site Number : 8400045 | Kansas City | Kansas | 66160 | — |
| University of Michigan Health System - Ann Arbor- Site Number : 8400055 | Ann Arbor | Michigan | 48109 | — |
| Pulmonary and Medicine Associates- Site Number : 8400057 | Warren | Michigan | 48088 | — |
| Washington University- Site Number : 8400046 | St Louis | Missouri | 63110 | — |
| NYU Langone Medical Center- Site Number : 8400032 | New York | New York | 10016 | — |
| American Health Research - Charlotte- Site Number : 8400017 | Charlotte | North Carolina | 28277 | — |
| Advanced Respiratory and Sleep Medicine - Huntersville- Site Number : 8400009 | Huntersville | North Carolina | 28078 | — |
| Southeastern Research Center- Site Number : 8400008 | Winston-Salem | North Carolina | 27103 | — |
| Clinical Research Associates of Central PA - Dubois- Site Number : 8400005 | DuBois | Pennsylvania | 15801 | — |
| Penn Medicine: University of Pennsylvania Health System- Site Number : 8400039 | Philadelphia | Pennsylvania | 19104 | — |
| Temple University Hospital- Site Number : 8400015 | Philadelphia | Pennsylvania | 19140 | — |
| Medical University of South Carolina - Charleston - Jonathan Lucas Street- Site Number : 8400027 | Charleston | South Carolina | 29425 | — |
| Metroplex Pulmonary and Sleep Center- Site Number : 8400014 | McKinney | Texas | 75069 | — |
| Plano Primary Care Clinic- Site Number : 8400019 | Plano | Texas | 75024 | — |
| Pioneer Research Solutions, Inc.- Site Number : 8400048 | Sugar Land | Texas | 77479 | — |
| The University of Texas Health Center at Tyler- Site Number : 8400053 | Tyler | Texas | 75708 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 106 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06280391, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 11, 2026 · Synced May 6, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06280391 live on ClinicalTrials.gov.