Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer
Public ClinicalTrials.gov record NCT06282575. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-label Randomized Trial of the Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy Alone for Advanced HER2-positive Biliary Tract Cancer
Study identification
- NCT ID
- NCT06282575
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Jazz Pharmaceuticals
- Industry
- Enrollment
- 286 participants
Conditions and interventions
Conditions
Interventions
- Cisplatin Drug
- Durvalumab Drug
- Gemcitabine Drug
- Pembrolizumab Drug
- Zanidatamab Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 18, 2024
- Primary completion
- Nov 30, 2028
- Completion
- Mar 31, 2030
- Last update posted
- Mar 23, 2026
2024 – 2030
United States locations
- U.S. sites
- 21
- U.S. states
- 17
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| City of Hope(City of Hope National Medical Center, City of Hope Medical Center) | Duarte | California | 91010 | Recruiting |
| Rocky Mountain Cancer Centers, LLP | Lone Tree | Colorado | 80124 | Active, not recruiting |
| AdventHealth Hematology and Oncology | Orlando | Florida | 32804 | Recruiting |
| Winship Cancer Institute | Atlanta | Georgia | 30322 | Recruiting |
| The University of Kansas Cancer Center - Westwood | Westwood | Kansas | 66205 | Active, not recruiting |
| Norton Cancer Institute - Audubon | Louisville | Kentucky | 40217 | Recruiting |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | Recruiting |
| Tufts Medical Center | Boston | Massachusetts | 02111 | Active, not recruiting |
| University of Michigan Hospital | Ann Arbor | Michigan | 48109 | Recruiting |
| Henry Ford Health System | Detroit | Michigan | 48202 | Recruiting |
| Minnesota Oncology Hematology, P.A. | Maple Grove | Minnesota | 55369 | Active, not recruiting |
| Atlantic Health System/Morristown Medical Center | Morristown | New Jersey | 07960 | Active, not recruiting |
| Laura and Isaac Perlmutter Cancer Center at NYU Langone - Ambulatory Care Center | New York | New York | 10016 | Recruiting |
| Memorial Sloan Kettering Cancer Centers | New York | New York | 10022 | Recruiting |
| Oregon Health and Science University | Portland | Oregon | 97239 | Recruiting |
| Saint Francis Cancer Center | Greenville | South Carolina | 29607 | Recruiting |
| SCRI Oncology Partners | Nashville | Tennessee | 37203 | Active, not recruiting |
| Texas Oncology - DFW | Dallas | Texas | 75246 | Active, not recruiting |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | Recruiting |
| The Univerrsity of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
| Virginia Commonwealth University, VCU Health | Richmond | Virginia | 23219 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 163 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06282575, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 23, 2026 · Synced May 5, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06282575 live on ClinicalTrials.gov.