A Study of AAV2-GDNF in Adults With Moderate Parkinson's Disease (REGENERATE-PD)
Public ClinicalTrials.gov record NCT06285643. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized, Double-blind, Sham Surgery-controlled Study of the Efficacy and Safety of Intraputaminal AAV2-GDNF in the Treatment of Adults With Moderate Stage Parkinson's Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The objective of this randomized, surgically controlled, double-blinded, Phase 2 study is to evaluate the safety and efficacy of AAV2-GDNF delivered to the putamen in subjects with moderate Parkinson's Disease.
Study identification
- NCT ID
- NCT06285643
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 127 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 45 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 11, 2024 (Actual)
- Primary completion
- Aug 31, 2028 (Estimated)
- Completion
- Aug 31, 2028 (Estimated)
- Last update posted
- Oct 1, 2026
2024 – 2028
United States locations
- U.S. sites
- 34
- U.S. states
- 20
- U.S. cities
- 29
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic | Phoenix | Arizona | 85054 | — |
| UCI Alpha Clinic (Neurology) | Irvine | California | 92697 | — |
| Loma Linda University (Neurology) | Loma Linda | California | 92354 | — |
| Loma Linda University (Surgical) | Loma Linda | California | 92354 | — |
| University of California San Francisco (Neurology) | San Francisco | California | 94143 | — |
| University of San Francisco (Surgical) | San Francisco | California | 94143 | — |
| CenExel Rocky Mountain Clinical Research (Neurology) | Englewood | Colorado | 80113 | — |
| Georgetown University (Neurology) | Washington D.C. | District of Columbia | 20057 | — |
| Parkinson's Disease and Movement Disorders Center of Boca Raton (Neurology) | Boca Raton | Florida | 33486 | — |
| University of Florida | Gainesville | Florida | 32608 | — |
| University of Miami | Miami | Florida | 33125 | — |
| Orlando Health Neuroscience Institute | Orlando | Florida | 32806 | — |
| Parkinson's Disease Treatment Center of Southwest Florida (Neurology) | Port Charlotte | Florida | 33980 | — |
| Emory University (Surgical) | Atlanta | Georgia | 30322 | — |
| Rush University Medical Center (Neurology) | Chicago | Illinois | 60612 | — |
| University of Kansas Medical Center (Neurology) | Kansas City | Kansas | 66103 | — |
| Massachusetts General Hospital (Neurology) | Boston | Massachusetts | 02114 | — |
| Massachusetts General Hospital (Surgical) | Boston | Massachusetts | 02114 | — |
| Michigan State University (Neurology) | East Lansing | Michigan | 48824 | — |
| Quest Research Institute (Neurology) | Farmington Hills | Michigan | 48334 | — |
| Cleveland Clinic Lou Ruvo (Neurology) | Las Vegas | Nevada | 89106 | — |
| Columbia University | New York | New York | 10032 | — |
| University of North Carolina (Neurology) | Chapel Hill | North Carolina | 27514 | — |
| Duke Neurosurgery (Surgical) | Durham | North Carolina | 27705 | — |
| Duke University (Neurology) | Durham | North Carolina | 27710 | — |
| Ohio State University (Surgical) | Columbus | Ohio | 43210 | — |
| University of Pennsylvania (Neurology) | Philadelphia | Pennsylvania | 19104 | — |
| Vanderbilt University (Neurology) | Nashville | Tennessee | 37232 | — |
| Texas Movement Disorder Specialists | Georgetown | Texas | 78628 | — |
| Houston Methodist (Neurology) | Houston | Texas | 77030 | — |
| Houston Methodist (Surgical) | Houston | Texas | 77030 | — |
| University of Utah | Salt Lake City | Utah | 84132 | — |
| EvergreenHealth Research Department (Neurology) | Kirkland | Washington | 98034 | — |
| University of Wisconsin (Neurology) | Madison | Wisconsin | 53705 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 12 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06285643, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 1, 2026 · Synced Oct 24, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06285643 live on ClinicalTrials.gov.