RECOVER-AUTONOMIC Platform Protocol
Public ClinicalTrials.gov record NCT06305780. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
RECOVER-AUTONOMIC: A Platform Protocol for Evaluation of Interventions for Autonomic Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is a platform protocol designed to be flexible so that it is suitable for a wide range of settings within health care systems and in community settings where it can be integrated into COVID-19 programs and subsequent treatment plans. This protocol is a prospective, multi-center, multi-arm, randomized, controlled platform trial evaluating various interventions for use in the treatment of autonomic dysfunction symptoms, including cardiovascular complications and postural orthostatic tachycardia syndrome (POTS), in PASC participants. The interventions tested will include non-pharmacologic care and pharmacologic therapies with study drugs.
Study identification
- NCT ID
- NCT06305780
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 381 participants
Conditions and interventions
Conditions
Interventions
- IVIG + Coordinated Care Drug
- IVIG Placebo + Coordinated Care Drug
- Ivabradine + Coordinated Care Drug
- Ivabradine Placebo + Coordinated Care Drug
- IVIG + Usual Care Drug
- IVIG Placebo + Usual Care Drug
- Ivabradine + Usual Care Drug
- Ivabradine Placebo + Usual Care Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 11, 2024 (Actual)
- Primary completion
- Jul 9, 2025 (Actual)
- Completion
- Jul 9, 2025 (Actual)
- Last update posted
- Aug 3, 2026
2024 – 2025
United States locations
- U.S. sites
- 50
- U.S. states
- 33
- U.S. cities
- 48
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| East Alabama Medical Center - Appendix B Only | Opelika | Alabama | 36801 | — |
| Center for Complex Neurology - Appendix A & B | Phoenix | Arizona | 85006 | — |
| University of Arkansas for Medical Sciences - Appendix A & B | Little Rock | Arkansas | 72205 | — |
| University of California San Diego - Appendix B Only | La Jolla | California | 92307 | — |
| Cedars Sinai Medical Center - Appendix A & B | Los Angeles | California | 90048 | — |
| Stanford University - Appendix B Only | Stanford | California | 94305 | — |
| University of Colorado Anschutz Medical Campus Clinical and Translational Research Center (CTRC) - Appendix A & B | Aurora | Colorado | 80045 | — |
| MedStar National Rehabilitation Hospital - Appendix B only | Washington D.C. | District of Columbia | 20010 | — |
| University of Florida Health - Appendix A & B | Gainesville | Florida | 32610 | — |
| Lakeland Regional Medical Center - Appendix A & B | Lakeland | Florida | 33805 | — |
| Innovation Clinical Trials Inc.- Appendix A & B | Palmetto Bay | Florida | 33157 | — |
| Grady Memorial Hospital - Woodruff Memorial Research - Appendix A & B | Atlanta | Georgia | 30303 | — |
| Morehouse School of Medicine - Appendix A & B | Atlanta | Georgia | 30310 | — |
| Queens Medical Center - Appendix B Only | Honolulu | Hawaii | 96813 | — |
| Rush University Medical Center - Appendix B Only | Chicago | Illinois | 60612 | — |
| University of Illinois at Chicago - Appendix A & B | Chicago | Illinois | 60612 | — |
| NorthShore University HealthSystem - Evanston Hospital - Appendix B Only | Evanston | Illinois | 60201 | — |
| University of Iowa - Appendix A & B | Iowa City | Iowa | 52242 | — |
| University of Kansas Medical Center CTSU Fairway - Appendix A & B | Fairway | Kansas | 66205 | — |
| University of Kentucky Medical Center - Appendix A & B | Lexington | Kentucky | 40536 | — |
| University Medical Center New Orleans - Appendix A & B | New Orleans | Louisiana | 70112 | — |
| Johns Hopkins Hospital - Appendix A Only | Baltimore | Maryland | 21287 | — |
| Brigham and Women's Hospital - Appendix A Only | Boston | Massachusetts | 02115 | — |
| Henry Ford Hospital - Appendix A & B | Detroit | Michigan | 48202 | — |
| Mayo Clinic - Appendix A & B | Rochester | Minnesota | 55905 | — |
| University of Mississippi Medical Center - Appendix A & B | Jackson | Mississippi | 39216 | — |
| Washington University School of Medicine - Appendix B Only | St Louis | Missouri | 63110 | — |
| University at Buffalo - Appendix A & B | Buffalo | New York | 14203 | — |
| St. Lawrence Health Medical Campus - Appendix A & B | Canton | New York | 13617 | — |
| Columbia University Irving Medical Center - Appendix A & B | New York | New York | 10032 | — |
| Stony Brook University Hospital - Appendix A & B | Stony Brook | New York | 11794 | — |
| Montefiore Medical Center - Moses Campus - Appendix B | The Bronx | New York | 10467 | — |
| Duke University Hospital - Appendix A & B | Durham | North Carolina | 27710 | — |
| East Carolina University - Appendix B Only | Greenville | North Carolina | 27834 | — |
| Cleveland Clinic - Appendix A & B | Cleveland | Ohio | 44195 | — |
| University of Oklahoma Health Science Center - Oklahoma Clinical and Translational Science Institute - Appendix A & B | Oklahoma City | Oklahoma | 73104 | — |
| Oregon Health and Science University - Appendix A & B | Portland | Oregon | 97239 | — |
| Kent Hospital - Appendix A & B | Pawtucket | Rhode Island | 02860 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| National Neuromuscular Research Institute - Appendix A & B | Austin | Texas | 78759 | — |
| Southwest Family Medicine Associates - Appendix A & B | Dallas | Texas | 75235 | — |
| University of Texas Health Science Center at Houston | Houston | Texas | 78701 | — |
| University of Texas Health Science Center at San Antonio - Appendix A & B | San Antonio | Texas | 78229 | — |
| Bateman Horne Center - Appendix B Only | Salt Lake City | Utah | 84102 | — |
| Vermont Lung Center, University of Vermont - Appendix B Only | Burlington | Vermont | 05405 | — |
| University of Virginia Health System, University Hospital - Appendix A & B | Charlottesville | Virginia | 22908 | — |
| Sentara Norfolk General Hospital - Appendix A & B | Norfolk | Virginia | 23507 | — |
| Evergreen Hospital Medical Center - Appendix A & B | Kirkland | Washington | 98034 | — |
| Providence Medical Research Center - Appendix A & B | Spokane | Washington | 99204 | — |
| Marshall Health - University Physicians and Surgeons - Appendix A & B | Huntington | West Virginia | 25701 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06305780, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 3, 2026 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06305780 live on ClinicalTrials.gov.